Results 231 to 240 of about 61,480 (319)

Application of Physiologically-Based Pharmacokinetic Modeling to Support Drug Labeling: Prediction of CYP3A4-Mediated Pirtobrutinib-Drug Interactions. [PDF]

CPT Pharmacometrics Syst Pharmacol
Tian DD, Hall SD, Chapman SC, Posada MM.
europepmc   +1 more source

Opportunities of patient‐derived organoids in drug development

British Journal of Pharmacology, Volume 183, Issue 4, Page 939-944, February 2026.
Various model systems are utilised during drug development starting from basic research, moving to preclinical research and development for clinical applications in order to identify new drugs to improve human health. However, there are characteristics of humans that are not captured by established models.
Antonia Büning, Elena Reckzeh
wiley   +1 more source

Concurrent Administration of Triazoles with Chemotherapeutic and/or Immunosuppressant Agents Known to Have Moderate-to-Severe Drug-Drug Interactions in Patients with Hematologic Malignancies Hospitalized for Invasive Aspergillosis. [PDF]

Mycopathologia
Walsh TJ, Coleman CI, Johnson MD, Lovelace B, Alexander BD.   +4 more
europepmc   +1 more source

Co-Based Carbon Material as Cyp3a4-Like Nanozyme with Both Biocatalytic Activity and Inhibition Behaviors

Dong Wu, Yamei Lin
openalex   +1 more source

Влияние полиморфизмов генов АВСВ1 (rs4148738) и CYP3A4*22 (rs35599367) на терапию блокатором медленных кальциевых каналов амлодипином у больных артериальной гипертензией

, 2018
Marina Galieva, Е. А. Трошина, Н. В. Мазурина, А. П. Волынкина, Морозова Татьяна Евгеньевна, Рыжиков Акристина Анатольевна, Гришина Елена Анатольевна, Созаева Жаннет Алимовна   +7 more
openalex   +1 more source

Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age‐Related Studies in Thai Adults and Cross‐Population Comparisons

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Intrinsic factors such as age and ethnicity influence statin pharmacokinetics (PK) and may increase the risk of muscle‐related adverse events. This study investigated the effect of age on the PK of simvastatin (SV) and its active metabolite, simvastatin acid (SVA), in healthy Thai subjects using an LC–MS/MS assay while accounting for key ...
Thanate Srimatimanon, Udomsak Udomnilobol, Pajaree Chariyavilaskul, Sarawut Siwamogsatham, Kearkiat Praditpornsilpa, Yongkasem Vorasettakarnkij, Aisawan Petchlorlian, Natchaya Vanwong, Jittima Piriyapongsa, Pavita Tipsombatboon, Varalee Yodsurang, Thomayant Prueksaritanont   +11 more
wiley   +1 more source

Investigating the therapeutic mechanism of Asarum for oral ulcer from a network pharmacology perspective. [PDF]

Medicine (Baltimore)
Zhu X, Zhao M, Zhu H, Wang Y, Lu Y.
europepmc   +1 more source

Influence of quercetin and chrysin on the intestinal permeability of paclitaxel, a substrate of P-glycoprotein and CYP3A4 using in vitro rat gut sacs

, 2019
Ravindra Babu Pingili, Manasa Aparna Kambhampati, Sowjanya Vaka, Naveen Babu Kilaru   +3 more
openalex   +2 more sources

Echinacea purpurea up-regulates CYP1A2, CYP3A4 and MDR1 gene expression by activation of pregnane X receptor pathway

Xenobiotica; the fate of foreign compounds in biological systems, 2015
C. Awortwe, V. Manda, Cristina Avonto, Shabana I. Khan, I. Khan, L. Walker, P. Bouic, B. Rosenkranz   +7 more
semanticscholar   +1 more source

Open‐Label Study Assessing Relative and Absolute Bioavailability of Oral Camizestrant Formulations and Food Effects in Healthy Postmenopausal Women

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Camizestrant is the next‐generation oral selective estrogen receptor degrader and complete estrogen receptor antagonist in Phase 3 development for hormone receptor‐positive breast cancer. To investigate the impact of manufacturing changes during pivotal Phase 3 studies, this open‐label, randomized crossover study of 32 postmenopausal healthy ...
Andy Sykes, Helena Engman, Nigel Taylor, Tim Brier, Rhiannon Maudsley, Bistra Kirova, Alastair M. Mathewson, Ryan A. Bragg, Malin Gränfors, Eric T. Gangl, Teresa Klinowska, Yan Li, Somasekhar R. Menakuru, Chris Roe, John McDermott, Justin P. O. Lindemann   +15 more
wiley   +1 more source