Results 211 to 220 of about 56,913 (295)

Development of Novel Furan–Chalcone Derivatives as Targeting Bacterial DNA Gyrase and Topoisomerase IV: Design, Synthesis, and In Silico Studies

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
Furan–chalcone derivatives (Na1–Na8) were successfully designed, synthesized, and biologically evaluated using integrated experimental and computational approaches. ABSTRACT A series of novel furan–chalcone derivatives (Na1–Na8) were synthesized and evaluated for their antimicrobial, antioxidant, DNA gyrase inhibitory, and computational properties ...
Nagaraj N Durgadasheemi, Vishal CS
wiley   +1 more source

Therapeutic Potential of Propolis in Ulcerative Colitis: A Review of Preclinical Evidence

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
This review compiles preclinical evidence from studies that investigate the therapeutic potential of propolis extracts derived from different botanical origins, as well as their main bioactive constituents, in the context of ulcerative colitis. The observed beneficial effects are primarily attributed to their antioxidant, immunomodulatory, and anti ...
Thayná Fernandes Barros, Gabriel Gomes Vila Nova, Rosane Nassar Meireles Guerra, Flavia Raquel Fernandes do Nascimento, Afonso Gomes Abreu   +4 more
wiley   +1 more source

Exploring the treatment of liver cancer with Gehua Hugan Gao based on bioinformatics, network pharmacology, and molecular docking. [PDF]

Medicine (Baltimore)
Ye G, Yang Z, Yang B, Chen D, Li D, Yan H, Qiu H, Long F, Wu W, Tang D.   +9 more
europepmc   +1 more source

Ascites Presenting as a Peritonitis‐Like Manifestation and Liver Injury due to Trabectedin Monotherapy in a Patient With Myxoid Liposarcoma

Cancer Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Background Trabectedin is a synthetic, marine‐derived antitumor agent that exerts cytotoxic effects by binding to the minor groove of DNA. While trabectedin has demonstrated efficacy in advanced soft tissue sarcomas, hepatotoxicity and other adverse events remain concerns.
Tatsuyuki Kawahara, Hiromichi Yamane, Ayaka Mimura, Hirohito Kirishi, Yusuke Sunada, Yoko Kosaka, Naruhiko Ichiyama, Yasunari Nagasaki, Nobuaki Ochi, Hidekazu Nakanishi, Hideyo Fujiwara, Nagio Takigawa   +11 more
wiley   +1 more source

Oxidative Susceptibility of Coumarin-1,2,3-Triazole-Isatin Hybrids: Integrating In Silico CYP-Mediated Metabolism Prediction with Electrochemistry-Mass Spectrometry. [PDF]

Pharmaceuticals (Basel)
Dimkovski A, Krzhovska D, Dobričić V, Simić MR, Mihajloska E, Nestorovska AK, Grozdanova A, Poceva Panovska A, Sterjev Z.   +8 more
europepmc   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1315-1325, November 2026.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Impact of Cytochrome P450 and P-glycoprotein Gene Polymorphisms on the Risk of Hemorrhagic Complications in Older Patients with Non-Valvular Atrial Fibrillation Treated with Rivaroxaban. [PDF]

J Pers Med
Sychev IV, Kondrakhin AP, Abdullaev SP, Bochkov PO, Tuchkova SN, Selivanova LV, Fedorinov DS, Milovanova OA, Mirzaev KB, Sychev DA.   +9 more
europepmc   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1338-1347, November 2026.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Integrated assessment of rifampicin‐mediated induction of transporters and drug‐metabolizing enzymes in a long‐term human liver tissue chip system

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1368-1378, November 2026.
Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer, Raeanne M. Lanphier, Shivam Ohri, Jessica Snyder, Jacqueline B. Tiley, John K. Fallon, Henry Ho, Murat Cirit, Shiny Amala Priya Rajan, Kim L. R. Brouwer   +9 more
wiley   +1 more source

Application of Virtual Twin PBPK Models in Individuals with Obesity via CYP3A4 Phenotyping Using Endogenous Biomarker Data. [PDF]

Clin Pharmacol Ther
Izat N, Kangne H, Jansson-Löfmark R, Hertel JK, Rostami-Hodjegan A, Robertsen I, Galetin A.   +6 more
europepmc   +1 more source