Results 31 to 40 of about 75,915 (258)
ASM Science Journal, 2022 The cytochrome P450 (CYP) enzymes are of a ubiquitous heme–thiolate proteins family that plays an important role within the biotransformation of endogenous molecules and xenobiotics as today’s market is bio-transformed through CYP-mediated metabolism ...
Fazleen Haslinda Mohd Hatta +4 more
doaj +1 more source
CYP3A4∗22 Genotyping in Clinical Practice: Ready for Implementation?
Frontiers in Genetics, 2021 Cytochrome P450 3A4 (CYP3A4) is the most important drug metabolizing enzyme in the liver, responsible for the oxidative metabolism of ∼50% of clinically prescribed drugs.
Tessa A. M. Mulder +12 more
doaj +1 more source
Everolimus dosing recommendations for tuberous sclerosis complex–associated refractory seizures [PDF]
, 2018 ObjectiveThe present analysis examined the exposure-response relationship by means of the predose everolimus concentration (C-min) and the seizure response in patients with tuberous sclerosis complex-associated seizures in the EXIST-3 study ...
Brandt, Christian +12 more
core +2 more sources
Journal of Pharmacological Sciences, 2004 A relatively large amount of human liver tissue was required to determine the exact activity of human hepatic CYP3A. Although, the quantity of available human liver tissue samples is limited.
Minoru Watanabe +6 more
doaj +1 more source
Effect of verapamil on the pharmacokinetics of hydroxycamptothecin and its potential mechanism
Pharmaceutical Biology, 2020 Context Hydroxycamptothecin (HCPT) has antitumor activity in various cancers, but its poor bioavailability and efflux limit its clinical application. Verapamil has been demonstrated to improve the bioavailability of many drugs.
Hua Xing +6 more
doaj +1 more source
Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences [PDF]
, 2015 Herbal medicines are currently in high demand, and their popularity is steadily increasing. Because of their perceived effectiveness, fewer side effects and relatively low cost, they are being used for the management of numerous medical conditions ...
Horie, Toshiharu +3 more
core +1 more source
Simulated microgravity promotes the formation of tridimensional cultures and stimulates pluripotency and a glycolytic metabolism in human hepatic and biliary tree stem/progenitor cells [PDF]
, 2019 Many pivotal biological cell processes are affected by gravity. The aim of our study was to evaluate biological and functional effects, differentiation potential and exo-metabolome profile of simulated microgravity (SMG) on human hepatic cell line (HepG2)
Alvaro, Domenico +14 more
core +2 more sources
CYP3A4 and CYP3A5genotyping by Pyrosequencing [PDF]
BMC Medical Genetics, 2005 Human cytochrome P450 3A enzymes, particularly CYP3A4 and CYP3A5, play an important role in drug metabolism. CYP3A expression exhibits substantial interindividual variation, much of which may result from genetic variation. This study describes Pyrosequencing assays for key SNPs in CYP3A4 (CYP3A4*1B, CYP3A4*2, and CYP3A4*3) and CYP3A5 (CYP3A5*3C and ...
McLeod Howard L +2 more
openaire +3 more sources
Genetic diversity of and polymorphisms in North African populations from Morocco and Tunisia
The International Journal of Biological Markers, 2015 The genes CYP3A4 and CYP3A5 form part of a cluster of cytochrome P450 genes involved in drug metabolism reactions. The allelic variants of these genes CYP3A4*1B, CYP3A4*3, CYP3A4*17 and CYP3A5*3 have been linked both to the reduced catalytic activity of ...
Apolonia Novillo +7 more
doaj +1 more source
Direct Acting Antiviral Drugs: Pharmacokinetics and Drug-Drug Interactions
Archives of Pharmaceutical Sciences Ain Shams University, 2022 Hepatitis C (HCV) is a widespread health issue, which can lead to hepatic cirrhosis, liver failure, and liver cancer. Nearly 2% of the world's population or > 185 million people are chronically infected with HCV; the management of HCV and the rate of ...
Marina Barakat +3 more
doaj +1 more source