Results 101 to 110 of about 25,509 (198)

Effect of MRSA on CYP450: dynamic changes of cytokines, oxidative stress, and drug-metabolizing enzymes in mice infected with MRSA

, 2018
Huaqiao Tang,1,2,* Nana Long,1,2,* Lin Lin,1,2 Yao Liu,1 Jianlong Li,1,2 Fenghui Sun,1,2 Lijuan Guo,1,2 Fen Zhang,3 Min Dai1,2 1School of Laboratory Medicine, 2Laboratory of Veterinary Drug Residue Prevention and Control Technology of Animal-derived Food,
Liu Y, Zhang F, Dai M, Sun FH, Long NN, Guo LJ, Li JL, Tang HQ, Lin L   +8 more
core  

Genome-wide identification and transcriptome analysis of the cytochrome P450 genes revealed its potential role in the growth of Flammulina filiformis

BMC Genomics
Background The CYP450 family members have been extensively studied in plants, where they play essential roles in metabolism, responses to biotic and abiotic stresses, and the regulation of growth and development.
Xun Liu, Xinmin Liang, Jing Han, Yuqin Cui, Mengting Lei, Bo Wang, Dinghong Jia, Weihong Peng, Xiaolan He   +8 more
doaj   +1 more source

Brassica napus cytochrome P450 superfamily: Origin from parental species and involvement in diseases resistance, abiotic stresses tolerance, and seed quality traits

Ecotoxicology and Environmental Safety
Cytochromes P450 monooxygenases (CYP450s) constitute the largest enzymic protein family that is widely present in plants, animals, and microorganisms, participate in numerous metabolic pathways, and play diverse roles in development, metabolism, and ...
Yufei Xue, Shanshan Wang, Qiheng Zhang, Fangzhou Wu, Li Huang, Shujun Qin, Min Zhang, Xiao Yang, Zihan Deng, Huanhuan Jiang, Lejing Li, Yourong Chai   +11 more
doaj   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, Volume 13, Issue 61, 3 November 2026.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Evolution of key genes for complex coumarin biosynthesis in Apiaceae (CYP450 gene family phylogeny).

Cyclases responsible for the last step of CCs biosynthesis in Apiaceae are membersthe CYP450 superfamily.
Huang Xincheng (17755563)
core   +1 more source

An Immune‐Metabolic Signature Reveals Prognostic Stratification and Tumor Microenvironment Features in Breast Cancer

Cancer Medicine, Volume 15, Issue 11, November 2026.
This study developed and validated an 11‐gene immune‐metabolic riskScore that independently stratifies overall survival in breast cancer across multiple public and institutional cohorts. It further reveals distinct stromal–immune states, CAF‐related programs, and potential immunotherapy responsiveness, supporting its prognostic and translational value.
Sijia Dong, Wenxiao Xu, Shan Liu, Kun Zhang, Kaihong Deng, Zhigao Li, He Ren   +6 more
wiley   +1 more source

ArcDFI: Attention regularization guided by CYP450 interactions for predicting drug-food interactions.

PLoS Computational Biology
CYP450 isoenzymes are known to be deeply involved in the formation of drug-food interactions (DFI). Previously introduced computational approaches for predicting DFIs do not take drug-CYP450 interactions (DCI) into account and have limited ...
Mogan Gim, Jaewoo Kang, Donghyeon Park, Minji Jeon   +3 more
doaj   +1 more source

Quinoxaline–Triazole Hybrids: Exploring the Impact of Substituent Architecture on Cytotoxic Potency and Receptor Interaction

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
A series of title compounds was synthesized, with 6e and 6k exhibiting the lowest IC50 values against MCF‐7, HeLa, and HepG2 cancer cell lines. Molecular docking and dynamics revealed strong binding to the adenosine A1 receptor (ΔG = –9.02 and –9.24 kcal/mol).
Bangar Reddy Vancha, Mandapalli Sreeshitha, Shaik Farheen Banu, Kamala Prasad Vasikarla, Satyanarayana Swamy Vyshnava, Mukhriddin Makhkamov, Parthiban Marimuthu, Jamoliddin Razzokov, Aminul Islam, Peddiahgari Vasu Govardhana Reddy   +9 more
wiley   +1 more source

Biosynthetic Pathways and Regulation of Antibacterial Compounds From Endophytic Fungi: From Chemistry to Genomics and Biotechnology

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
Endophytic fungi encode abundant cryptic biosynthetic gene clusters that remain largely silent under conventional cultivation. This review highlights how genome mining, multi‐omics, and cluster activation strategies bridge the BGC‐to‐metabolite gap, enabling the discovery of structurally diverse antibacterial natural products with activity against ...
Farkhod Eshboev, Abubakar Siddiq Salihu, Lobar Khayrullaeva, Doniyor Khamdamov, Alex X. Gao, Kamila Mardieva, Wan Mohd Nuzul Hakimi Wan Salleh, Shakhnoz Azimova, Karl W. K. Tsim   +8 more
wiley   +1 more source

Aflatoxin B1 Exacerbates Ketogenic Diet‐Induced Hepatic Oxidative Stress and Glucose and Lipid Metabolic Disturbances in Mice

Food Frontiers, Volume 7, Issue 6, November 2026.
AFB1 exposure aggravates KD‐associated hepatic oxidative stress, inflammation, and glucose and lipid metabolic disturbances in mice. These effects are accompanied by dysregulation of AMPK, mTOR, and PPAR‐γ signaling and extensive hepatic metabolic reprogramming. ABSTRACT Aflatoxin B1 (AFB1) is a widespread mycotoxin with severe hepatotoxicity.
Xueyuan Hu, Zhenjun Sun, Xiaojing Wang, Shaochun Liu, ZhenBang Ye, Xueshu Han, Yang Ni, Linlin Hou, Yongping Chen, Huanqi Liu   +9 more
wiley   +1 more source