Results 111 to 120 of about 25,509 (198)

Genome-wide identification and expression analyses of CYP450 genes in sweet potato (Ipomoea batatas L.)

BMC Genomics
Background Cytochrome P450 monooxygenases (CYP450s) play a crucial role in various biochemical reactions involved in the synthesis of antioxidants, pigments, structural polymers, and defense-related compounds in plants. As sweet potato (Ipomoea batatas L.
Xiongjian Lin, Binquan Tang, Zhenqin Li, Lei Shi, Hongbo Zhu   +4 more
doaj   +1 more source

Antimicrobial Activity and In Silico ADME Properties of Tyrosol and Their Derivatives Compounds

ChemistrySelect, Volume 11, Issue 41, 3 November 2026.
In the present study, tyrosol derivatives were obtained with the aim of improving their antimicrobial activity. Derivative 2 exhibited good antimicrobial activity, with an MIC of 3.9 µg/mL. Derivative 3, meanwhile, showed moderate activity and is novel in the literature. ABSTRACT According to the World Health Organization (WHO), bacterial resistance is
Kathia Raquel Murillo Padilla, Rayanne Priscila Vieira da Conceição, José Edson de Sousa Siqueira, Luana Cardoso de Oliveira, Mayra Suelen da Silva Pinheiro, Patrícia Santana Barbosa Marinho, Andrey Moacir do Rosario Marinho   +6 more
wiley   +1 more source

Effects of 6‐OHDA‐Mediated Chemical Denervation of Sympathetic Axons in Inguinal Subcutaneous White Adipose Tissue

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10459-10474, November 2026.
ABSTRACT Aims White adipose tissue (WAT) innervation by sensory and sympathetic axons contributes to tissue functions, but the consequences of selectively disrupting sympathetic input to WAT remain incompletely defined. Materials and Methods We utilised 6‐hydroxydopamine (6‐OHDA) as a validated approach to achieve bilateral sympathetic denervation of ...
Gilian Gunsch, Gargi Mishra, Magdalena Blaszkiewicz, Erica de Sousa, Jake W. Willows, Katharine W. Alltop, Annemarie Towle, Shawn Collins, Andre Khalil, Isabel F. Snodgrass, Lara Agha, Kiran Prakash, Rashmika Maganuru, Sugasini Dhavamani, John W. Newman, Kristy L. Townsend   +15 more
wiley   +1 more source

Phenotyping of human CYP450 enzymes by endobiotics: current knowledge and methodological approaches

, 2019
Drug response is subject to an important within- and between-individual variability owing, mainly, to pharmacokinetic and pharmacodynamic factors. Pharmacokinetics includes metabolism by cytochrome P450 (CYP450), major enzymes of phase I reactions that ...
Desmeules, J., Daali, Youssef, Desmeules, Jules Alexandre, Thomas, Aurélien, Daali, Y., Thomas, A., Magliocco, Gaëlle, Magliocco, G., Thomas A, Magliocco G, Desmeules J, Daali Y   +11 more
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Chronic alcohol intake disrupts cytochrome P450 enzyme activity in alcoholic fatty liver disease: insights into metabolic alterations and therapeutic targets

Frontiers in Chemistry
IntroductionAlcoholic fatty liver disease (AFLD) is a common consequence of chronic alcohol consumption, characterized by lipid accumulation and oxidative stress in the liver.
Qian Zhu, Xuefeng Xie, Ling Fang, Cheng Huang, Jun Li   +4 more
doaj   +1 more source

Systematic Optimization of an SLE‐DAPTAD LC–MS/MS Workflow for Simultaneous Quantification of Low‐Abundance Vitamin D3 Metabolites in Plasma

Rapid Communications in Mass Spectrometry, Volume 40, Issue 20, 30 October 2026.
ABSTRACT Rationale Liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis of vitamin D3 metabolites is analytically challenging because these compounds are structurally similar, strongly matrix‐associated, and have poor ionization efficiency.
Marzieh Amirmostofian, Michael D. Wiese, Paul H. Anderson, Peter Hoffmann   +3 more
wiley   +1 more source

Selenomethionine Alleviates AFB1-Induced Damage in Primary Chicken Hepatocytes by Inhibiting CYP450 1A5 Expression via Upregulated SelW Expression

, 2017
This study aims to evaluate the protective effects of selenomethionine (SeMet) on aflatoxin B1 (AFB1)-induced hepatotoxicity in primary chicken hepatocytes.
Che C, Pan C, Korolchuk VI, Huang K, Chen X, Gan F   +5 more
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Profiling the accumulation of ten bioactive compounds in Rheum officinale across different growth years using integrated HPLC and transcriptomic approaches

Medicinal Plant Biology
Rheum officinale is a prominent traditional medicinal herb in the Chinese Pharmacopeia. Variations in the composition and accumulation of secondary metabolites in R. officinale have been observed to correlate with harvest periods. This study investigated
Yi-min Li, Xue-ru Wang, Ge Yang, Ting-ting Yan, Xiao-chen Hu, Liang Peng, Jing Gao, Feng Yan, Gang Zhang   +8 more
doaj   +1 more source

Medicinal Chemistry Aspects of Thiazole and Thiazolidine Derivatives as Fundamental Building Blocks to Design New NNRTIs Against HIV‐1 Reverse Transcriptase

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
HIV‐1 reverse transcriptase (HIV‐1 RT) is a polymerase enzyme and a key target in HIV‐1 therapy. The discovery of selective HIV‐1 RT inhibitors has highlighted thiazole scaffolds and their derivatives, thiazolidine‐2‐one and thiazolidine‐2,4‐dione, as promising structures for the rational design of novel non‐nucleoside reverse transcriptase inhibitors (
José Arion da Silva Moura, Matheus Vinicius Guimarães de Melo, Diane Regis Santos do Nascimento, Thaynara Paula Warren Bezerra, Mathieu Métifiot, Patricia Recordon‐Pinson, Maira Galdino da Rocha Pitta, Marina Galdino da Rocha Pitta, Michelly Cristiny Pereira, Marie‐Line Andreola   +9 more
wiley   +1 more source

Patient Summary: Genetic Testing for CYP450 and Use of SSRIs for Depression in Adults [PDF]

Patient Summary: Genetic Testing for CYP450 and Use of SSRIs for Depression in Adults.

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