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Treatment of Depression With Cyproheptadine
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1995We evaluated the antidepressant activity of cyproheptadine HCl in six patients diagnosed with major depression. This was a double‐blind, placebo‐controlled, crossover trial with treatment order balanced and randomly assigned. The patients received 4 weeks of treatment with cyproheptadine HCl 4 mg 4 times/day or placebo, followed by 4 weeks of ...
S E, Greenway, A T, Pack, F L, Greenway
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On the anticataleptic action of cyproheptadine
Pharmacology Biochemistry and Behavior, 1976The anticataleptic action of cyproheptadine, a tricyclic compound known as antiserotonin, anticholinergic and antihistaminic drug in comparison to that of atropine, promethazine, imipramine, desipramine, chlorimipramine and nomifensine was studied in rats.
J, Maj, J, Sarnek, V, Klimek, A, Rawlów
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Cyproheptadine in Anorexia Nervosa
British Journal of Psychiatry, 1979SummaryIn three hospitals 81 female patients satisfying rigorous diagnostic criteria for anorexia nervosa were randomly allocated to one of four treatment combinations of cyproheptadine and placebo with behaviour therapy and no behaviour therapy. Cyproheptadine was found to be effective in inducing weight gain in a subgroup of anorexia nervosa patients
S C, Goldberg +4 more
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HUMAN METABOLISM OF CYPROHEPTADINE
Drug Metabolism and Disposition, 1975Gas-liquid chromatographic and mass, nuclear magnetic resonance, and infrared spectrometric techniques were utilized to identify some of the metabolites of cyproheptadine in the urine of human subjects who had ingested radiolabeled drug. Aromatic ring hydroxylation (followed by glucuronide conjugation), N-demethylation, and heterocyclic ring oxidation ...
C C, Porter +4 more
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Conformational analysis of cyproheptadine hydrochloride
Journal of Medicinal Chemistry, 1990A nuclear magnetic resonance and theoretical study on the conformations and molecular flexibility of cyproheptadine hydrochloride (1) is reported. In the 1H NMR spectrum of 1 in CDCl3, two conformational forms are observed to occur in an approximate ratio of 1:4. In both forms, NOE and coupling constant measurements suggested that the terminal N-methyl
Sadek, M +3 more
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Annals of Internal Medicine, 1980
Excerpt To the editor: The recent article by Dr. Tah-Hsiung Hsu (1) states that cyproheptadine may induce breast enlargement and that "this complication may be viewed as beneficial in most women." ...
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Excerpt To the editor: The recent article by Dr. Tah-Hsiung Hsu (1) states that cyproheptadine may induce breast enlargement and that "this complication may be viewed as beneficial in most women." ...
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