Results 131 to 140 of about 34,415 (185)

L‐cysteine/cystathionine‐β‐synthase‐induced relaxation in mouse aorta involves a L‐serine/sphingosine‐1‐phosphate/NO pathway

British Journal of Pharmacology, 2019
Among the three enzymes involved in the transsulfuration pathway, only cystathionine β‐synthase (CBS) converts L‐cysteine into L‐serine and H2S. L‐serine is also involved in the de novo sphingolipid biosynthesis through a condensation with palmitoyl‐CoA ...
E. Mitidieri, Danila Gurgone, E. Caiazzo, T. Tramontano, C. Cicala, R. Sorrentino, R. d'Emmanuele di Villa Bianca   +6 more
semanticscholar   +1 more source

A Rapid Screening Method for the Measurement of Neonatal Total Homocysteine in Dried Blood Spots by Liquid Chromatography-Tandem Mass Spectrometry

International Journal of Neonatal Screening, 2017
Homocystinuria (HCU) due to cystathionine-β-synthase deficiency is generally regarded as a rare disease, but within the Qatari population has an incidence of 1 in 1800 live births. Most newborn screening methods for HCU using dried blood spots (DBS) rely
Rose Maase, Victor Skrinska, Noura Younes, Lubna Hassan, Rola Mitri, Dietrich Matern, Piero Rinaldo, Coleman Turgeon   +7 more
doaj   +1 more source

Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE)

British Journal of Pharmacology, 2013
Hydrogen sulfide (H2S) is a signalling molecule that belongs to the gasotransmitter family. Two major sources for endogenous enzymatic production of H2S are cystathionine β synthase (CBS) and cystathionine γ lyase (CSE). In the present study, we examined
Antonia Asimakopoulou, Panagiotis Panopoulos, Christos T. Chasapis, C. Coletta, Zongmin Zhou, G. Cirino, A. Giannis, C. Szabó, G. Spyroulias, A. Papapetropoulos   +9 more
semanticscholar   +1 more source

Arylthioamides and aryliminothioethers as new slow H2S-releasing agents [PDF]

Hydrogen sulphide (H2S) is emerging as an important endogenous modulator, which exhibits the beneficial effects of nitric oxide (NO) on the cardiovascular (CV) system, without producing toxic metabolites.
ANGELINI, MARIAGRAZIA
core  

Hydrogen sulfide reduces oxidative stress in Huntington’s disease via Nrf2

Neural Regeneration Research
The pathophysiology of Huntington’s disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic
Zige Jiang, Dexiang Liu, Tingting Li, Chengcheng Gai, Danqing Xin, Yijing Zhao, Yan Song, Yahong Cheng, Tong Li, Zhen Wang   +9 more
doaj   +1 more source

Alterations in lipid profile and enzymes paraoxonase and butyrylcholinesterase in CBS-deficient patients [PDF]

, 2014
Homocystinuria is an inborn error of metabolism most frequently caused by cystathionine β-synthase (CBS) deficiency. Homocysteine (Hcy), methionine (Met) and other metabolites of Hcy accumulate in the body of affected patients, leading to clinical ...
Nogueira, Célia, Vanzin, Camila, Vargas, Carmen, Vilarinho, Laura, Wajner, Moacir, Wyse, Angela   +5 more
core  

ICI 182,780 Attenuates Selective Upregulation of Uterine Artery Cystathionine β-Synthase Expression in Rat Pregnancy. [PDF]

Int J Mol Sci, 2023
Bai J, Li Y, Yan G, Zhou J, Salmeron AG, Fategbe OT, Kumar S, Chen X, Chen DB.   +8 more
europepmc   +1 more source

Cystathionine β-synthase affects organization of cytoskeleton and modulates carcinogenesis in colorectal carcinoma cells. [PDF]

Front Oncol, 2023
Liskova V, Chovancova B, Babula P, Rezuchova I, Pavlov KP, Matuskova M, Krizanova O.   +6 more
europepmc   +1 more source

Hydrogen sulfide and its role in female reproduction

Frontiers in Veterinary Science
Hydrogen sulfide (H2S) is a gaseous signaling molecule produced in the body by three enzymes: cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST).
Aneta Pilsova, Zuzana Pilsova, Barbora Klusackova, Natalie Zelenkova, Eva Chmelikova, Pavla Postlerova, Marketa Sedmikova   +6 more
doaj   +1 more source

The Structure and Nucleotide-Binding Characteristics of Regulated Cystathionine β-Synthase Domain-Containing Pyrophosphatase without One Catalytic Domain. [PDF]

Int J Mol Sci, 2023
Zamakhov IM, Anashkin VA, Moiseenko AV, Orlov VN, Vorobyeva NN, Sokolova OS, Baykov AA.   +6 more
europepmc   +1 more source