Results 91 to 100 of about 10,826 (180)

Endothelial Cell Cystathionine γ‐Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2020
Background Hydrogen sulfide (H2S) is an important endogenous physiological signaling molecule and exerts protective properties in the cardiovascular system.
Huijing Xia, Zhen Li, Thomas E. Sharp, David J. Polhemus, J. Carnal, Karl Moles, Y. Tao, J. Elrod, J. Pfeilschifter, K. Beck, D. Lefer   +10 more
semanticscholar   +1 more source

Longitudinal metabolomics study of phosphate‐adenine‐guanosine‐glucose‐saline‐mannitol stored red blood cells

Transfusion, EarlyView.
Abstract Background The storage of red blood cells (RBCs) is essential for transfusion but leads to storage lesions that compromise RBC quality and increase the risk of transfusion‐related adverse effects, including allergic transfusion reactions (ATRs). Understanding storage‐induced metabolic change is crucial for enhancing transfusion safety.
Gürkan Bal, Maia Dzamashvili, Zhuoran Li, Magda Babina, Nidal Toman, Abdulgabar Salama   +5 more
wiley   +1 more source

Genetically encoded fluorescent redox probes. [PDF]

, 2013
Redox processes are involved in almost every cell of the body as a consequence of aerobic life. In the past decades, redox biology has been increasingly recognized as one of the key themes in cell signaling.
Ai, Hui-Wang, Ren, Wei
core   +3 more sources

Sodium thiosulfate treatment rescues hyperglycaemia‐induced pronephros damage in zebrafish by upregulating nitric oxide signalling

The Journal of Physiology, EarlyView.
Abstract figure legend Sodium thiosulfate (STS) rescues the pronephros phenotype of pdx1 morphants through compensatory upregulation of nitric oxide (NO) metabolism. Zebrafish larvae injected with a control morpholino show the typical pronephros structure at 48 h post‐fertilization (hpf) with and without STS treatment.
Hannes Ott, Katrin Bennewitz, Xin Zhang, Mariia Prianichnikova, Carsten Sticht, Gernot Poschet, Jens Kroll   +6 more
wiley   +1 more source

Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review

Journal of Advanced Research, 2021
Background: Insulin resistance and impaired insulin secretion lead to disorders of glucose metabolism, which contributes to the development of diabetes.
Heng Zhang, Yaqian Huang, Selena Chen, Chaoshu Tang, Guang Wang, Junbao Du, Hongfang Jin   +6 more
doaj   +1 more source

Anomalous Kv 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle. [PDF]

BACKGROUND AND PURPOSE: Human malignant hyperthermia (MH) syndrome is induced by volatile anaesthetics and involves increased levels of cystathionine β-synthase (CBS)-derived H2 S within skeletal muscle.
Basso Elisabetta, Maria, Bibli Iris, Sophia, Bucci, Mariarosaria, Calderone, Vincenzo, Cirino, Giuseppe., Citi, Valentina, Cozzolino, Catia, de Dominicis, Gianfranco, Fleming, Ingrid, Mancini, Antonio, Manzo, ONORINA LAURA, Mariniello, Martina, Martelli, Alma, Panza, Elisabetta, Vallifuoco, Marianna, Vellecco, Valentina   +15 more
core   +1 more source

Gasotransmitters: novel regulators of ion channels and transporters [PDF]

, 2013
More than 25 years ago, it was a big surprise for physiologists that nitric oxide (NO) was identified as the endothelium derived relaxing factor which is responsible for endothelium-induced smooth muscle relaxation (Ignarro et al., 1987).
Mike Althaus, Wolfgang G. Clauss
core   +2 more sources

N‐Acetylcysteine‐Loaded Scaffolds and Their Role in Extracellular ROS and Redox‐Related Gene Regulation in Chondrocytes

Macromolecular Materials and Engineering, Volume 311, Issue 2, February 2026.
This study develops N‐acetylcysteine‐loaded polycaprolactone fibers for cartilage regeneration to investigate their potential in regulating redox balance. The fibers exhibit antioxidant properties and modulate genes related to glutathione and transsulfuration pathways.
Kubra Yigit, Anthony Callanan
wiley   +1 more source

Role of Hydrogen Sulfide in the Pathology of Inflammation

Scientifica, 2012
Hydrogen sulfide (H2S) is a well-known toxic gas that is synthesized in the human body from the amino acids cystathionine, homocysteine, and cysteine by the action of at least two distinct enzymes: cystathionine-γ-lyase and cystathionine-β-synthase.
Madhav Bhatia
doaj   +1 more source

Nitric oxide and hydrogen sulfide: the gasotransmitter paradigm of the vascular system. [PDF]

, 2017
There are several reviews on NO and hydrogen sulfide (H2 S) and their role in vascular diseases in the current relevant literature. The aim of this review is to discuss, within the limits of present knowledge, the interconnection between these two ...
Bucci, M., Cirino, G, Vellecco, V
core   +1 more source