Nature Communications, 2021 Dietary restriction (DR) can increase protein persulfidation but the tissue specificity of this process is not well understood. Here, the authors compare organ-specific protein persulfidomes in young and aged mice under DR, and show that DR-dependent ...
Nazmin Bithi +8 more
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Host cystathionine-γ lyase derived hydrogen sulfide protects against Pseudomonas aeruginosa sepsis.
PLoS Pathogens, 2021 Hydrogen sulfide (H2S) has recently been recognized as a novel gaseous transmitter with several anti-inflammatory properties. The role of host- derived H2S in infections by Pseudomonas aeruginosa was investigated in clinical and mouse models.
Georgios Renieris +19 more
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Mechanism of Growth Regulation of Yeast Involving Hydrogen Sulfide From S-Propargyl-Cysteine Catalyzed by Cystathionine-γ-Lyase [PDF]
Frontiers in Microbiology, 2021 Pathogenic fungi are recognized as a progressive threat to humans, particularly those with the immunocompromised condition. The growth of fungi is controlled by several factors, one of which is signaling molecules, such as hydrogen sulfide (H2S), which ...
Zhongkai Gu +3 more
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Cystathionine γ-Lyase Self-Inactivates by Polysulfidation during Cystine Metabolism. [PDF]
Int J Mol Sci, 2023 Cystathionine γ-lyase (CSE) is an enzyme responsible for the biosynthesis of cysteine from cystathionine in the final step of the transsulfuration pathway. It also has β-lyase activity toward cystine, generating cysteine persulfide (Cys-SSH).
Araki S +9 more
europepmc +2 more sources
Cystathionine γ-lyase S-sulfhydrates SIRT1 to attenuate myocardial death in isoprenaline-induced heart failure. [PDF]
Redox Rep, 2023 Objective: Hydrogen sulfide (H2S), the third gasotransmitter, plays a critical role in protecting against heart failure. Sirtuin-1 (SIRT1) is a highly conserved histone deacetylase that has a protective role in the treatment of heart failure by ...
Wu D, Sun Y, Gu Y, Zhu D.
europepmc +2 more sources
Hepatocellular cystathionine γ lyase/hydrogen sulfide attenuates nonalcoholic fatty liver disease by activating farnesoid X receptor. [PDF]
Hepatology, 2022 Hydrogen sulfide (H2S) plays a protective role in NAFLD. However, whether cystathionine γ lyase (CSE), a dominant H2S generating enzyme in hepatocytes, has a role in the pathogenesis of NAFLD is currently unclear.
Xu W +15 more
europepmc +2 more sources
Naphthyl-Substituted Indole and Pyrrole Carboxylic Acids as Effective Antibiotic Potentiators-Inhibitors of Bacterial Cystathionine γ-Lyase. [PDF]
Int J Mol Sci, 2023 Over the past decades, the problem of bacterial resistance to most antibiotics has become a serious threat to patients’ survival. Nevertheless, antibiotics of a novel class have not been approved since the 1980s.
Kuzovlev AS +13 more
europepmc +2 more sources
Structural basis of the inhibition of cystathionine γ-lyase from Toxoplasma gondii by propargylglycine and cysteine. [PDF]
Protein Sci, 2023 Cystathionine γ‐lyase (CGL) is a PLP‐dependent enzyme that catalyzes the last step of the reverse transsulfuration route for endogenous cysteine biosynthesis.
Fernández-Rodríguez C +7 more
europepmc +2 more sources
Dual targeting of H2S synthesizing enzymes; cystathionine β-synthase and cystathionine γ-lyase by miR-939-5p effectively curbs triple negative breast cancer. [PDF]
Heliyon, 2023 Nafea H +8 more
europepmc +2 more sources
Estradiol of various saturation and its influence on hydrogen sulfide formation in the myocardium of female rats. [PDF]
Medičnì Perspektivi, 2015 Hydrogen sulfide is signalling molecule that regulates vascular tone and myocardial contractility. Role of estradiol in hydrogen sulfide production in cardiovascular system of rats remains unclear and this becames research objective.
A. V. Melnik
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