Results 21 to 30 of about 412,162 (161)

Overexpression of Cystathionine γ-Lyase Suppresses Detrimental Effects of Spinocerebellar Ataxia Type 3 [PDF]

, 2019
Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine (polyQ) disorder caused by a CAG repeat expansion in the ataxin-3 (ATXN3) gene resulting in toxic protein aggregation. Inflammation and oxidative stress are considered secondary factors contributing
Leuvenink, Henri G. D., Kampinga, Harm H., Filipovic, Milos R., Dijkers, Pascale F., Kuipers, Jeroen, Bos, Eelke M., van Goor, Harry, Szabó, Csaba, Snijder, Pauline M., Sibon, Ody C. M., Miljkovic, Jan Lj, Kuijpers, Lucas, Giepmans, Ben N. G., Schaap, Onno, Huitema, Sippie, Baratashvili, Madina, Grzeschik, Nicola A., Mitrovic, Aleksandra, den Dunnen, Wilfred F. A.   +18 more
core   +3 more sources

Dietary restriction transforms the mammalian protein persulfidome in a tissue-specific and cystathionine γ-lyase-dependent manner

Nature Communications, 2021
Dietary restriction (DR) can increase protein persulfidation but the tissue specificity of this process is not well understood. Here, the authors compare organ-specific protein persulfidomes in young and aged mice under DR, and show that DR-dependent ...
Nazmin Bithi, Christopher Link, Yoko O. Henderson, Suzie Kim, Jie Yang, Ling Li, Rui Wang, Belinda Willard, Christopher Hine   +8 more
doaj   +1 more source

Profiling Cystathionine /-Lyase in Complex Biosamples Using Novel Activatable Fluorogens

, 2021
Cystathionine lyase, the key enzyme in transsulfuration and reverse transsulfuration pathways, is involved in a wide array of physiological and pathophysiological processes in both mammals and nonmammals.
Jiayue Wang (3136224), Yiying Wang (3344264), Yanxi Pei (475881), Keli Han (1629946), Yan Jia, Peng Li, Yongli Zhang, Jiayue Wang, Peng Li (69518), Yanxi Pei, Yongli Zhang (274182), Yiying Wang, Keli Han, Zhiqing Wang (830081), Zhiqing Wang, Yan Jia (198590)   +15 more
core   +1 more source

Harnessing the Benefits of Endogenous Hydrogen Sulfide to Reduce Cardiovascular Disease

Antioxidants, 2021
Cardiovascular disease is the leading cause of death in the U.S. While various studies have shown the beneficial impact of exogenous hydrogen sulfide (H2S)-releasing drugs, few have demonstrated the influence of endogenous H2S production.
Kevin M. Casin, John W. Calvert
doaj   +1 more source

Discovery of a Bioactive Inhibitor with a New Scaffold for Cystathionine γ‑Lyase

, 2018
We identify three submicromolar inhibitors with new chemical scaffolds for cystathionine γ-lyase (CSE) by a tandem-well-based high-throughput assay. NSC4056, the most potent inhibitor with an IC50 of 0.6 μM, which is also known as aurintricarboxylic acid,
Jielin Sun (123338), Ting Hong (318109), Xu Han (141301), Yueyang Zhou (1819225), Wei Zhang (405), Jing Yu (81085), Yingxin Qi (6165596), Hong Liu (50694), Lu Wang (45927), Xun-Xiang Guo (1991677), Fang Wu (267711), Youtian Hu (502367), Tonghui Zhang (6017585), Li Wang (15202)   +13 more
core   +3 more sources

Mutant Huntingtin Derails Cysteine Metabolism in Huntington’s Disease at Both Transcriptional and Post-Translational Levels

Antioxidants, 2022
Cysteine is a semi-essential amino acid that not only plays an essential role as a component of protein synthesis, but also in the generation of numerous sulfur-containing molecules such as the antioxidant glutathione and coenzyme A. We previously showed
Bindu D. Paul, Juan I. Sbodio, Solomon H. Snyder   +2 more
doaj   +1 more source

Mechanism-based and computational modeling of hydrogen sulfide biogenesis inhibition: interfacial inhibition

Scientific Reports, 2023
Hydrogen sulfide (H2S) is a gaseous signaling molecule that participates in various signaling functions in health and diseases. The tetrameric cystathionine γ-lyase (CSE) contributes to H2S biogenesis and several investigations provide evidence on the ...
Laurent Le Corre, Dominique Padovani
doaj   +1 more source

Cysteine Persulfide Formation by Enterobacteriaceae Bacteria and Cloned Mammalian Cystathionine γ-Lyase [PDF]

, 2021
Polysulfides and persulfides (RSSxR and RSSH) have become topics of significant interest due to prevalence in eukaryotic and prokaryotic systems. Cysteine trisulfide (CysSSSCys) has been found to be able to be reduced by Escherichia coli and produce ...
Irwin, Drew
core  

Host cystathionine-γ lyase derived hydrogen sulfide protects against Pseudomonas aeruginosa sepsis.

PLoS Pathogens, 2021
Hydrogen sulfide (H2S) has recently been recognized as a novel gaseous transmitter with several anti-inflammatory properties. The role of host- derived H2S in infections by Pseudomonas aeruginosa was investigated in clinical and mouse models.
Georgios Renieris, Dionysia-Eirini Droggiti, Konstantina Katrini, Panagiotis Koufargyris, Theologia Gkavogianni, Eleni Karakike, Nikolaos Antonakos, Georgia Damoraki, Athanasios Karageorgos, Labros Sabracos, Antonia Katsouda, Elisa Jentho, Sebastian Weis, Rui Wang, Michael Bauer, Csaba Szabo, Kalliopi Platoni, Vasilios Kouloulias, Andreas Papapetropoulos, Evangelos J Giamarellos-Bourboulis   +19 more
doaj   +1 more source

Short-term preoperative protein restriction attenuates vein graft disease via induction of cystathionine γ-lyase [PDF]

, 2020
Therapies to prevent vein graft disease, a major problem in cardiovascular and lower extremity bypass surgeries, are currently lacking. Short-term preoperative protein restriction holds promise as an effective preconditioning method against surgical ...
MacArthur, Michael R, Trocha, K.M., Toussaint, W., Trocha, Kaspar M, Quax, Paul H A, Trevino-Villarreal, J.H., Lambrecht, Bart, Ozaki, C Keith, MacArthur, M.R., Treviño-Villarreal, J Humberto, Vries, M.R. de, Mitchell, James R, Quax, P.H.A., de Vries, Margreet R, Longchamp, A., Mitchell, J.R., Longchamp, Alban, Ozaki, C.K., Tao, M., Lambrecht, B.N., Kip, Peter, Kip, P., Tao, Ming, Toussaint, Wendy   +23 more
core   +1 more source