Results 31 to 40 of about 412,162 (161)

The endogenous production of hydrogen sulphide in intrauterine tissues [PDF]

, 2009
Background: Hydrogen sulphide is a gas signalling molecule which is produced endogenously from L-cysteine via the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).
Patel Pushpa, Carson Ray J, Patel, Pushpa, Heptinstall, John, Heptinstall, J, Wang, Rui, Carson, RJ, Rui Wang, John Heptinstall (7594472), Pushpa Patel, Carson, Ray J., Pushpa Patel (2697712), Heptinstall John, Rui Wang (52434), Vatish Manu, Vatish, M, Ray J Carson, Manu Vatish (187260), Wang Rui, Wang, R, Ray J. Carson (7594475), Vatish, Manu, Manu Vatish, John Heptinstall   +23 more
core   +1 more source

Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na+/Ca2+ Exchanger

Cellular and Molecular Gastroenterology and Hepatology, 2018
Hydrogen sulfide (H2S) is a major physiologic gastrotransmitter. Its role in the regulation of the lower esophageal sphincter (LES) function remains unknown. The present study addresses this question.
Xiaopeng Bai, Eikichi Ihara, Katsuya Hirano, Yoshimasa Tanaka, Kayoko Nakano, Satomi Kita, Takahiro Iwamoto, Haruei Ogino, Mayumi Hirano, Yoshinao Oda, Kazuhiko Nakamura, Yoshihiro Ogawa   +11 more
doaj   +1 more source

Analysis of the sulfur-regulated control of the cystathionine γ-lyase gene of Neurospora crassa

BMC Research Notes, 2012
Background Cystathionine γ-lyase plays a key role in the transsulfuration pathway through its primary reaction of catalyzing the formation of cysteine from cystathionine.
Reveal Brad S, Paietta John V
doaj   +1 more source

Colorimetric coupled enzyme assay for cystathionine β-synthase [PDF]

, 2016
A colorimetric coupled enzyme assay for the determination of cystathionine β-synthase activity is described. The method exploits cystathionine γ-lyase as an ancillary enzyme capable of transforming cystathionine, produced by cystathionine β-synthase ...
BALESTRI, FRANCESCO, MOSCHINI, ROBERTA, MURA, UMBERTO, Rocchiccioli, Marco, DEL CORSO, ANTONELLA, Cappiello, Laura, CAPPIELLO, MARIO   +6 more
core   +1 more source

Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

mBio, 2019
The reverse transsulfuration pathway is the major route for the metabolism of sulfur-containing amino acids. The role of this metabolic pathway in macrophage response and function is unknown. We show that the enzyme cystathionine γ-lyase (CTH) is induced
Alain P. Gobert, Yvonne L. Latour, Mohammad Asim, Jordan L. Finley, Thomas G. Verriere, Daniel P. Barry, Ginger L. Milne, Paula B. Luis, Claus Schneider, Emilio S. Rivera, Kristie Lindsey-Rose, Kevin L. Schey, Alberto G. Delgado, Johanna C. Sierra, M. Blanca Piazuelo, Keith T. Wilson   +15 more
doaj   +1 more source

Evidence of endogenously produced hydrogen sulfide (H2S) and persulfidation in male reproduction

Scientific Reports, 2022
Persulfidation contributes to a group of redox post-translational modifications (PTMs), which arise exclusively on the sulfhydryl group of cysteine as a result of hydrogen sulfide (H2S) action.
Hedvika Řimnáčová, Jiří Moravec, Miriama Štiavnická, Jiřina Havránková, Ladan Monsef, Petr Hošek, Šárka Prokešová, Tereza Žalmanová, Tereza Fenclová, Jaroslav Petr, Milena Králíčková, Jan Nevoral   +11 more
doaj   +1 more source

Zofenopril Protects Against Myocardial Ischemia–Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide Bioavailability

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundZofenopril, a sulfhydrylated angiotensin‐converting enzyme inhibitor (ACEI), reduces mortality and morbidity in infarcted patients to a greater extent than do other ACEIs.
Erminia Donnarumma, Murtuza J. Ali, Amanda M. Rushing, Amy L. Scarborough, Jessica M. Bradley, Chelsea L. Organ, Kazi N. Islam, David J. Polhemus, Stefano Evangelista, Giuseppe Cirino, J. Stephen Jenkins, Rajan A. G. Patel, David J. Lefer, Traci T. Goodchild   +13 more
doaj   +1 more source

The therapeutic potential for targeting CSE/H2S signaling in macrophages against Escherichia coli infection

Veterinary Research, 2023
Macrophages play a pivotal role in the inflammatory response to the zoonotic pathogen E. coli, responsible for causing enteric infections. While considerable research has been conducted to comprehend the pathogenesis of this disease, scant attention ...
Shaodong Fu, Zhenglei Wang, Xiangan Han, Yuanyuan Xu, Jinfeng Miao   +4 more
doaj   +1 more source

Cystathionine γ-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis

Redox Biology, 2021
During pregnancy, estrogen (E2) stimulates uterine artery blood flow (UBF) by enhancing nitric oxide (NO)-dependent vasodilation. Cystathionine γ-lyase (CSE) promotes vascular NO signaling by producing hydrogen sulfide (H2S) and by maintaining the ratio ...
Rachael Bok, Damian D. Guerra, Ramón A. Lorca, Sara A. Wennersten, Peter S. Harris, Abhishek K. Rauniyar, Sally P. Stabler, Kenneth N. MacLean, James R. Roede, Laura D. Brown, K. Joseph Hurt   +10 more
doaj   +1 more source

Functional characterization and structure-guided mutational analysis of the transsulfuration enzyme cystathionine γ-lyase from toxoplasma gondii [PDF]

, 2018
Sulfur-containing amino acids play essential roles in many organisms. The protozoan parasite Toxoplasma gondii includes the genes for cystathionine β-synthase and cystathionine γ-lyase (TgCGL), as well as for cysteine synthase, which are crucial enzymes ...
Rosario Vallone, Paola Dominici, Janson, Giacomo, Dominici, Paola, Elena Maresi, Maresi E, Astegno, Alessandra, VALLONE, ROBERTO, Fruncillo S, Paiardini, Alessandro, Vallone, Rosario, Astegno A., Maresi, Elena, Alessandro Paiardini, Janson G, FRUNCILLO, SILVIA, Giacomo Janson, Silvia Fruncillo, Alessandra Astegno, Paiardini A, Dominici P   +20 more
core   +1 more source