Results 21 to 30 of about 10,826 (180)

Cystathionine γ-lyase and hydrogen sulfide modulates glucose transporter Glut1 expression via NF-κB and PI3k/Akt in macrophages during inflammation. [PDF]

PLoS One, 2022
Macrophages play a crucial role in inflammation, a defense mechanism of the innate immune system. Metabolic function powered by glucose transporter isoform 1 (Glut1) is necessary for macrophage activity during inflammation. The present study investigated
Cornwell A, Fedotova S, Cowan S, Badiei A, Badiei A.   +4 more
europepmc   +2 more sources

Skeletal muscle cystathionine γ-lyase deficiency promotes obesity and insulin resistance and results in hyperglycemia and skeletal muscle injury upon HFD in mice. [PDF]

Redox Rep
Objectives The objective of this study was to investigate whether skeletal muscle cystathionine γ-lyase (CTH) contributes to high-fat diet (HFD)-induced metabolic disorders using skeletal muscle Cth knockout (CthΔskm) mice.
Lu J, Tang Z, Xu M, Lu J, Wang F, Ni X, Wang C, Yu B.   +7 more
europepmc   +2 more sources

Elucidation of the stereochemical mechanism of cystathionine γ-lyase reveals how substrate specificity constrains catalysis. [PDF]

ACS Catal
Pyridoxal phosphate (PLP)-dependent enzymes play essential roles in metabolism and have found applications for organic synthesis and as enzyme therapeutics.
Zmich A, Perkins LJ, Bingman C, Buller AR.   +3 more
europepmc   +2 more sources

Purification and characterization of cystathionine γ-lyase fromLactobacillus fermentumDT41 [PDF]

FEMS Microbiology Letters, 1998
A homo-tetrameric ca. 140-kDa cystathionine gamma-lyase was purified to homogeneity from Lactobacillus fermentum DT41 by four chromatographic steps. This was the first enzyme responsible for amino acid catabolism purified from lactobacilli. The activity is pyridoxal-5'-phosphate dependent and the enzyme catalyzes the alpha,gamma-elimination reaction of
E, Smacchi, M, Gobbetti
openaire   +2 more sources

Global Survey, Expressions and Association Analysis of CBLL Genes in Peanut

Frontiers in Genetics, 2022
Cystathionine γ-synthase (CGS), methionine γ-lyase (MGL), cystathionine β-lyase (CBL) and cystathionine γ-lyase (CGL) share the Cys_Met_Meta_PP domain and play important roles in plant stress response and development.
Weifang Ren, Weifang Ren, Weifang Ren, Zhaocong Zeng, Zhaocong Zeng, Zhaocong Zeng, Sijian Wang, Sijian Wang, Sijian Wang, Juncheng Zhang, Jiahai Fang, Jiahai Fang, Jiahai Fang, Liyun Wan, Liyun Wan, Liyun Wan   +15 more
doaj   +1 more source

Persulfidation of Human Cystathionine γ-Lyase Inhibits Its Activity: A Negative Feedback Regulation Mechanism for H₂S Production. [PDF]

Antioxidants (Basel)
Cystathionine γ-lyase (CSE) is the second enzyme in the trans-sulfuration pathway that converts cystathionine to cysteine. It is also one of three major enzymes responsible for the biosynthesis of hydrogen sulfide (H2S).
Jia G, Li H, Gan H, Wang J, Zhu Z, Wang Y, Ye Y, Shang X, Niu W.   +8 more
europepmc   +2 more sources

Ferroptosis due to Cystathionine γ Lyase/Hydrogen Sulfide Downregulation Under High Hydrostatic Pressure Exacerbates VSMC Dysfunction

Frontiers in Cell and Developmental Biology, 2022
Hydrostatic pressure, stretch, and shear are major biomechanical forces of vessels and play critical roles in genesis and development of hypertension.
Ruxi Jin, Ruixue Yang, Changting Cui, Haizeng Zhang, J.-G. Cai, B. Geng, Zhenzhen Chen   +6 more
semanticscholar   +1 more source

Cystine rather than cysteine is the preferred substrate for β-elimination by cystathionine γ-lyase: implications for dietary methionine restriction. [PDF]

Geroscience, 2023
Dietary methionine restriction (MR) increases longevity by improving health. In experimental models, MR is accompanied by decreased cystathionine β-synthase activity and increased cystathionine γ-lyase activity.
Jeitner TM, Azcona JA, Ables GP, Cooke D, Horowitz MC, Singh P, Kelly JM, Cooper AJL.   +7 more
europepmc   +2 more sources

Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin. [PDF]

Front Cell Dev Biol, 2021
The incidence of degenerative spinal diseases, such as cervical spondylosis and thoracic and lumbar disc herniation, is increasing. These health problems have adversely affected human life and work.
Xu H, Wei K, Tu J, Chen Y, He Y, Ding Y, Xu H, Bao X, Xie H, Fang H, Wang H.   +10 more
europepmc   +2 more sources

Hydrogen sulfide pathway and skeletal muscle: an introductory review. [PDF]

, 2018
The presence of the H2 S pathway in skeletal muscle (SKM) has recently been established. SKM expresses the three constitutive H2 S-generating enzymes in animals and humans, and it actively produces H2 S.
Armogida Chiara, Bucci Mariarosaria, Vellecco Valentina   +2 more
core   +4 more sources