Results 71 to 80 of about 10,826 (180)

Dysregulation of cystathionine γ‐lyase promotes prostate cancer progression and metastasis

EMBO Reports, 2019
Hydrogen sulfide (H2S), an endogenous signaling gaseous molecule, is involved in various physiological activities, including vessel relaxation, regulation of cellular bioenergetics, inflammation, and angiogenesis.
Yi-Hsiang Wang, Jo-Ting Huang, Wen-ling Chen, Rong-Hsuan Wang, Ming-Chien Kao, Yan-Ru Pan, Shih-Hsuan Chan, K. Tsai, H. Kung, Kai-Ti Lin, Lu‐Hai Wang   +10 more
semanticscholar   +1 more source

Hydrogen Sulfide Attenuates Lymphedema Via the Induction of Lymphangiogenesis Through a PI3K/Akt‐Dependent Mechanism

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Accumulating evidence suggests that hydrogen sulfide ( H2S ), an endogenously produced gaseous molecule, plays a critical role in the regulation of cardiovascular homeostasis. However, little is known about its role in lymphangiogenesis. Thus,
Junya Suzuki, Yuuki Shimizu, Takumi Hayashi, Yiyang Che, Zhongyue Pu, Kazuhito Tsuzuki, Shingo Narita, Rei Shibata, Isao Ishii, John W. Calvert, Toyoaki Murohara   +10 more
doaj   +1 more source

Overexpression of Cystathionine γ-Lyase Suppresses Detrimental Effects of Spinocerebellar Ataxia Type 3 [PDF]

, 2019
Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine (polyQ) disorder caused by a CAG repeat expansion in the ataxin-3 (ATXN3) gene resulting in toxic protein aggregation. Inflammation and oxidative stress are considered secondary factors contributing
Baratashvili, Madina, Bos, Eelke M., den Dunnen, Wilfred F. A., Dijkers, Pascale F., Filipovic, Milos R., Giepmans, Ben N. G., Grzeschik, Nicola A., Huitema, Sippie, Kampinga, Harm H., Kuijpers, Lucas, Kuipers, Jeroen, Leuvenink, Henri G. D., Miljkovic, Jan Lj, Mitrovic, Aleksandra, Schaap, Onno, Sibon, Ody C. M., Snijder, Pauline M., Szabó, Csaba, van Goor, Harry   +18 more
core   +2 more sources

CD4+ T-Cell Endogenous Cystathionine γ Lyase–Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation

Circulation, 2020
Supplemental Digital Content is available in the text. Background: Hydrogen sulfide (H2S) has antihypertension and anti-inflammatory effects, and its endogenous-generation key enzyme cystathionine γ lyase (CSE) is expressed in CD4+ T cells.
Changting Cui, Jinghui Fan, Q. Zeng, Junyan Cai, Yongzeng Chen, Zhenzhen Chen, Wenjie Wang, Shuangyue Li, Qinghua Cui, Jichun Yang, Chao-shu Tang, Guoheng Xu, Junyan Cai, B. Geng   +13 more
semanticscholar   +1 more source

Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-ε pathway and modulated by endogenous H2S [PDF]

, 2014
Activation of plasma membrane TGR5 receptors in enteroendocrine cells by bile acids is known to regulate gastrointestinal secretion and motility and glucose homeostasis.
Ancy D. Nalli, Arun J. Sanyal, Divya P. Kumar, John R. Grider, Karnam S. Murthy, Senthilkumar Rajagopal, Sunila Mahavadi, Vanitha Bala   +7 more
core   +2 more sources

Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features [PDF]

, 2016
Mutations that cause neurological phenotypes are highly informative with regard to mechanisms governing human brain function and disease. We report autosomal recessive mutations in the enzyme glutamate pyruvate transaminase 2 (GPT2) in large kindreds ...
Al-Saffar, Muna, Barkovich, A. James, Baytas, Ozan, Chaudhry, Haroon Rashid, Davidson, Shawn M, DeBerardinis, Ralph J., EI-Quessny, Malak, Gul Butt, Mirrat, Hill, R. Sean, Housman, David E, Imran Murtaza, Syed, Javed, Afzal, Lam, Anh-Thu N., Lizarraga, Sofia B., Mishra, Sasmita, Mochida, Ganeshwaran H., Morrow, Eric M., Nagpal, Shailender, Nakayama, Tojo, Nasir, Ramzi, Niaz, Saima, Ouyang, Qing, Partlow, Jennifer N., Rajab, Anna, Schmidt, Michael, Schwede, Matthew, Vaughan, Dylan J., Yang, Chendong, Yoo, Seung-Yun   +28 more
core   +1 more source

In Situ Synthesis of a Tumor Microenvironment‐Activated Radiosensitizing Cu2‐xS/LDH Probe for Photoacoustic Imaging‐Guided Radiotherapy

Advanced Science, EarlyView.
We reported a new kind of organic‐inorganic composite nanomaterial with excellent PA imaging performance after the in situ activation by hydrogen sulfide in colorectal cancer tissues, which was used for precise radiotherapy of colorectal cancer. It shows a great application potential for early diagnosis and treatment of tumor.
Kang Zhu, Qiaoqiao Wei, Ying Wu, Qingqing Li, Luntao Liu, Chunxiang Mo, Chuqiao Liu, Lichao Su, Jibin Song   +8 more
wiley   +1 more source

Production of hydrogen sulfide from D-cysteine and its therapeutic potential

Frontiers in Endocrinology, 2013
Accumulating evidence shows that H2S has physiological functions in various tissues and organs. It includes regulation of neuronal activity, vascular tension, a release of insulin, and protection of the heart, kidney and brain from ischemic insult. H2S
Norihiro eShibuya, Hideo eKimura
doaj   +1 more source

Influence of polymicroelement preparation Esmin on hydrogen sulfide levels and indices of pro- and antioxidant system in the rat myocardium of different age [PDF]

The Ukrainian Biochemical Journal, 2014
The influence of microelement preparation Esmin on hydrogen sulfide (H2S) levels, activity of H2S -producing enzymes and indices of pro-/antioxidant system in the myocardium of different age rats were investigated.
N. V. Zaichko, A. S. Olhovskiy, A. V. Melnik, P. A. Yurchenko, A. S. Grigorieva, N. F. Konahovich   +5 more
doaj   +1 more source

Single-enzyme biomineralization of cadmium sulfide nanocrystals with controlled optical properties [PDF]

, 2016
Nature has evolved several unique biomineralization strategies to direct the synthesis and growth of inorganic materials. These natural systems are complex, involving the interaction of multiple biomolecules to catalyze biomineralization and template ...
Berger, Bryan W., Dunleavy, Robert, Kiely, Christopher J., Lu, Li, McIntosh, Steven   +4 more
core   +1 more source