Results 91 to 100 of about 36,977 (144)

Hydrogen sulfide and inflammatory joint diseases [PDF]

, 2017
[Abstract] Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are widespread rheumatic diseases characterized by persistent inflammation and joint destruction. Hydrogen sulfide (H2S) is an endogenous gas with important physiologic functions in
Blanco García, Francisco J, Burguera, Elena F., Meijide-Faílde, Rosa   +2 more
core   +2 more sources

Choline supply during negative nutrient balance in Holstein cows alters hepatic cystathionine β-synthase, intermediates of the methionine cycle and transsulfuration pathway, and liver function in Holstein cows.

Journal of Dairy Science, 2019
Although choline requirements for cows are unknown, enhanced postruminal supply may decrease liver triacylglycerol and increase flux through the Met cycle to improve immunometabolic status during a negative nutrient balance (NNB).
D. Coleman, A. Alharthi, V. Lopreiato, E. Trevisi, M. Miura, Yuan Xiang Pan, J. Loor   +6 more
semanticscholar   +1 more source

AMPK:an energy-sensing pathway with multiple inputs and outputs [PDF]

, 2016
AMP-activated protein kinase (AMPK) is a key regulator of energy balance expressed ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide-dependent mechanism that activates AMPK when cellular energy status is compromised, as ...
Banko, Baur, Behrends, Blethrow, Calabrese, Carling, Chen, Chen, Cool, Corton, Crooks, Crute, Dale, Davies, DeRan, Ducommun, Egan, Fogarty, Gomez-Galeno, Goodwin, Goransson, Gowans, Grant, Gwinn, Habelhah, Hardie, Hardie, Hawley, Hawley, Hawley, Hawley, Hawley, Hoffman, Huang, Hudson, Hunter, Hurley, Huttlin, Istvan, Lai, Langendorf, Lee, Li, Marin, Michell, Mihaylova, Mitchelhill, Oakhill, Oakhill, Obenauer, Pang, Pirkmajer, Polekhina, Racanelli, Riek, Sanders, Schaffer, Scott, Scott, Shah, Songyang, Taylor, Tuerk, Tuerk, Weekes, Woods, Xiao, Xiao, Xiao, Xin, Yaffe, Zhang, Zhang   +72 more
core   +2 more sources

L‐cysteine/cystathionine‐β‐synthase‐induced relaxation in mouse aorta involves a L‐serine/sphingosine‐1‐phosphate/NO pathway

British Journal of Pharmacology, 2019
Among the three enzymes involved in the transsulfuration pathway, only cystathionine β‐synthase (CBS) converts L‐cysteine into L‐serine and H2S. L‐serine is also involved in the de novo sphingolipid biosynthesis through a condensation with palmitoyl‐CoA ...
E. Mitidieri, Danila Gurgone, E. Caiazzo, T. Tramontano, C. Cicala, R. Sorrentino, R. d'Emmanuele di Villa Bianca   +6 more
semanticscholar   +1 more source

Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE)

British Journal of Pharmacology, 2013
Hydrogen sulfide (H2S) is a signalling molecule that belongs to the gasotransmitter family. Two major sources for endogenous enzymatic production of H2S are cystathionine β synthase (CBS) and cystathionine γ lyase (CSE). In the present study, we examined
Antonia Asimakopoulou, Panagiotis Panopoulos, Christos T. Chasapis, C. Coletta, Zongmin Zhou, G. Cirino, A. Giannis, C. Szabó, G. Spyroulias, A. Papapetropoulos   +9 more
semanticscholar   +1 more source

ICI 182,780 Attenuates Selective Upregulation of Uterine Artery Cystathionine β-Synthase Expression in Rat Pregnancy. [PDF]

Int J Mol Sci, 2023
Bai J, Li Y, Yan G, Zhou J, Salmeron AG, Fategbe OT, Kumar S, Chen X, Chen DB.   +8 more
europepmc   +1 more source

Cystathionine β-synthase affects organization of cytoskeleton and modulates carcinogenesis in colorectal carcinoma cells. [PDF]

Front Oncol, 2023
Liskova V, Chovancova B, Babula P, Rezuchova I, Pavlov KP, Matuskova M, Krizanova O.   +6 more
europepmc   +1 more source

ON THE ROLE OF CYSTATHIONINE-γ-LYASE IN MODULATING TRANSSULFURATION PATHWAY IN THE LENS [PDF]

In Mammals transsulfuration pathway enables the conversion of homocysteine (Hcy), deriving from methionine (Met) transmetilation, into cysteine (Cys) through two steps, the first catalyzed by cystathionine β-synthase (CBS) and the second one by ...
CALVANI, ENRICA
core  

The impact of fish oil fatty-acids on post-prandial vascular reactivity. [PDF]

, 2014
Progressive loss of vascular reactivity and increased vascular tone with age are being increasingly recognised as significant cardiovascular disease (CVD) risk factors.
Mcmanus, Sean
core  

The Structure and Nucleotide-Binding Characteristics of Regulated Cystathionine β-Synthase Domain-Containing Pyrophosphatase without One Catalytic Domain. [PDF]

Int J Mol Sci, 2023
Zamakhov IM, Anashkin VA, Moiseenko AV, Orlov VN, Vorobyeva NN, Sokolova OS, Baykov AA.   +6 more
europepmc   +1 more source