Results 11 to 20 of about 12,014 (181)

Naphthyl-Substituted Indole and Pyrrole Carboxylic Acids as Effective Antibiotic Potentiators-Inhibitors of Bacterial Cystathionine γ-Lyase. [PDF]

Int J Mol Sci, 2023
Over the past decades, the problem of bacterial resistance to most antibiotics has become a serious threat to patients’ survival. Nevertheless, antibiotics of a novel class have not been approved since the 1980s.
Kuzovlev AS, Zybalov MD, Golovin AV, Gureev MA, Kasatkina MA, Biryukov MV, Belik AR, Silonov SA, Yunin MA, Zigangirova NA, Reshetnikov VV, Isakova YE, Porozov YB, Ivanov RA.   +13 more
europepmc   +2 more sources

Structural basis of the inhibition of cystathionine γ-lyase from Toxoplasma gondii by propargylglycine and cysteine. [PDF]

Protein Sci, 2023
Cystathionine γ‐lyase (CGL) is a PLP‐dependent enzyme that catalyzes the last step of the reverse transsulfuration route for endogenous cysteine biosynthesis.
Fernández-Rodríguez C, Conter C, Oyenarte I, Favretto F, Quintana I, Martinez-Chantar ML, Astegno A, Martínez-Cruz LA.   +7 more
europepmc   +2 more sources

Cystine rather than cysteine is the preferred substrate for β-elimination by cystathionine γ-lyase: implications for dietary methionine restriction. [PDF]

Geroscience, 2023
Dietary methionine restriction (MR) increases longevity by improving health. In experimental models, MR is accompanied by decreased cystathionine β-synthase activity and increased cystathionine γ-lyase activity.
Jeitner TM, Azcona JA, Ables GP, Cooke D, Horowitz MC, Singh P, Kelly JM, Cooper AJL.   +7 more
europepmc   +2 more sources

Cystathionine γ-lyase and hydrogen sulfide modulates glucose transporter Glut1 expression via NF-κB and PI3k/Akt in macrophages during inflammation. [PDF]

PLoS One, 2022
Macrophages play a crucial role in inflammation, a defense mechanism of the innate immune system. Metabolic function powered by glucose transporter isoform 1 (Glut1) is necessary for macrophage activity during inflammation. The present study investigated
Cornwell A, Fedotova S, Cowan S, Badiei A, Badiei A.   +4 more
europepmc   +2 more sources

Skeletal muscle cystathionine γ-lyase deficiency promotes obesity and insulin resistance and results in hyperglycemia and skeletal muscle injury upon HFD in mice. [PDF]

Redox Rep
Objectives The objective of this study was to investigate whether skeletal muscle cystathionine γ-lyase (CTH) contributes to high-fat diet (HFD)-induced metabolic disorders using skeletal muscle Cth knockout (CthΔskm) mice.
Lu J, Tang Z, Xu M, Lu J, Wang F, Ni X, Wang C, Yu B.   +7 more
europepmc   +2 more sources

Elucidation of the stereochemical mechanism of cystathionine γ-lyase reveals how substrate specificity constrains catalysis. [PDF]

ACS Catal
Pyridoxal phosphate (PLP)-dependent enzymes play essential roles in metabolism and have found applications for organic synthesis and as enzyme therapeutics.
Zmich A, Perkins LJ, Bingman C, Buller AR.   +3 more
europepmc   +2 more sources

Host cystathionine-γ lyase derived hydrogen sulfide protects against Pseudomonas aeruginosa sepsis.

PLoS Pathogens, 2021
Hydrogen sulfide (H2S) has recently been recognized as a novel gaseous transmitter with several anti-inflammatory properties. The role of host- derived H2S in infections by Pseudomonas aeruginosa was investigated in clinical and mouse models.
Georgios Renieris, Dionysia-Eirini Droggiti, Konstantina Katrini, Panagiotis Koufargyris, Theologia Gkavogianni, Eleni Karakike, Nikolaos Antonakos, Georgia Damoraki, Athanasios Karageorgos, Labros Sabracos, Antonia Katsouda, Elisa Jentho, Sebastian Weis, Rui Wang, Michael Bauer, Csaba Szabo, Kalliopi Platoni, Vasilios Kouloulias, Andreas Papapetropoulos, Evangelos J Giamarellos-Bourboulis   +19 more
doaj   +2 more sources

Cystathionine-γ-lyase overexpression modulates oxidized nicotinamide adenine dinucleotide biosynthesis and enhances neovascularization [PDF]

JVS - Vascular Science, 2023
Objective: Hydrogen sulfide is a proangiogenic gas produced primarily by the transsulfuration enzyme cystathionine-γ-lyase (CGL). CGL-dependent hydrogen sulfide production is required for neovascularization in models of peripheral arterial disease ...
Kevin Kiesworo, MS, Michael R. MacArthur, PhD, Peter Kip, MD, PhD, Thomas Agius, MS, Diane Macabrey, MS, Martine Lambelet, BS, Lauriane Hamard, PhD, C.-Keith Ozaki, MD, James R. Mitchell, PhD, Sébastien Déglise, MD, Sarah J. Mitchell, PhD, Florent Allagnat, PhD, Alban Longchamp, MD, PhD   +12 more
doaj   +2 more sources

Persulfidation of Human Cystathionine γ-Lyase Inhibits Its Activity: A Negative Feedback Regulation Mechanism for H₂S Production. [PDF]

Antioxidants (Basel)
Cystathionine γ-lyase (CSE) is the second enzyme in the trans-sulfuration pathway that converts cystathionine to cysteine. It is also one of three major enzymes responsible for the biosynthesis of hydrogen sulfide (H2S).
Jia G, Li H, Gan H, Wang J, Zhu Z, Wang Y, Ye Y, Shang X, Niu W.   +8 more
europepmc   +2 more sources

Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin. [PDF]

Front Cell Dev Biol, 2021
The incidence of degenerative spinal diseases, such as cervical spondylosis and thoracic and lumbar disc herniation, is increasing. These health problems have adversely affected human life and work.
Xu H, Wei K, Tu J, Chen Y, He Y, Ding Y, Xu H, Bao X, Xie H, Fang H, Wang H.   +10 more
europepmc   +2 more sources