Results 21 to 30 of about 12,014 (181)

Cystathionine-γ-lyase drives antioxidant defense in cysteine-restricted IDH1-mutant astrocytomas. [PDF]

Neurooncol Adv, 2021
Background Mutations in isocitrate dehydrogenase 1 or 2 (IDH1/2) define glioma subtypes and are considered primary events in gliomagenesis, impacting tumor epigenetics and metabolism.
Cano-Galiano A, Oudin A, Fack F, Allega MF, Sumpton D, Martinez-Garcia E, Dittmar G, Hau AC, De Falco A, Herold-Mende C, Bjerkvig R, Meiser J, Tardito S, Niclou SP.   +13 more
europepmc   +2 more sources

β₃ Relaxant Effect in Human Bladder Involves Cystathionine γ-Lyase-Derived Urothelial Hydrogen Sulfide. [PDF]

Antioxidants (Basel), 2022
It is now well established that the urothelium does not act as a passive barrier but contributes to bladder homeostasis by releasing several signaling molecules in response to physiological and chemical stimuli.
Mitidieri E, Pecoraro A, Esposito E, Brancaleone V, Turnaturi C, Napolitano L, Mirone V, Fusco F, Cirino G, Sorrentino R, Sorrentino R, Russo G, Russo A, d'Emmanuele di Villa Bianca R.   +13 more
europepmc   +2 more sources

USP9X-mediated REV1 deubiquitination promotes lung cancer radioresistance via the action of REV1 as a Rad18 molecular scaffold for cystathionine γ-lyase. [PDF]

J Biomed Sci
Radioresistance is a key clinical constraint on the efficacy of radiotherapy in lung cancer patients. REV1 DNA directed polymerase (REV1) plays an important role in repairing DNA damage and maintaining genomic stability.
Chen Y, Feng X, Wu Z, Yang Y, Rao X, Meng R, Zhang S, Dong X, Xu S, Wu G, Jie X.   +10 more
europepmc   +2 more sources

Down-Regulated Expression of Cystathionine β-Synthase and Cystathionine γ-Lyase in Varicocele, and Infertile Men: A Case-Control Study. [PDF]

Cell J, 2022
Objective Cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) are two important enzymes involved in One-Carbon metabolism. These enzymes play important roles in modulating oxidative stress and inflammation in male factor infertility through ...
Akbarian F, Tavalaee M, Dattilio M, Nasr-Esfahani MH.   +3 more
europepmc   +2 more sources

The Expression and Activity of Rhodanese, 3-Mercaptopyruvate Sulfurtransferase, Cystathionine γ-Lyase in the Most Frequently Chosen Cellular Research Models. [PDF]

Biomolecules, 2021
This paper provides information concerning the activity and expression levels of three sulfurtransferases (STRs): rhodanese (TST, EC: 2.8.1.1), 3-mercaptopyruvate sulfurtransferase (MPST, EC: 2.8.1.2) and cystathionine γ-lyase (CTH, EC: 4.4.1.1) in ...
Kaczor-Kamińska M, Kaminski K, Wróbel M.   +2 more
europepmc   +2 more sources

Cystathionine γ-lyase downregulation promotes liver injury and necroptosis through reprogramming of methionine cycle [PDF]

Redox Report
Objective Chronic liver diseases (CLDs) are prevalent globally. The purpose of the current study was to elucidate the regulatory mechanisms underlying the pathophysiological processes in CLDs.Methods and Results Using the GEO database, we identified ...
Cichun Wu, Wei Zhang, Wenhu Liu, Zhengshan Tang, Shifang Peng, Lei Fu, Xin Ni   +6 more
doaj   +2 more sources

Human Cystathionine γ-Lyase Is Inhibited by s-Nitrosation: A New Crosstalk Mechanism between NO and H₂S. [PDF]

Antioxidants (Basel), 2021
The ‘gasotransmitters’ hydrogen sulfide (H2S), nitric oxide (NO), and carbon monoxide (CO) act as second messengers in human physiology, mediating signal transduction via interaction with or chemical modification of protein targets, thereby regulating ...
Fernandes DGF, Nunes J, Tomé CS, Zuhra K, Costa JMF, Antunes AMM, Giuffrè A, Vicente JB.   +7 more
europepmc   +2 more sources

Hepatocyte FoxO1 depletion exacerbates hepatic inflammation in MASH by targeting cystathionine γ-lyase [PDF]

Scientific Reports
The transcription factor Forkhead box protein O1 (FoxO1) is a well-established regulator of glucose and lipid metabolism, yet its role in metabolic dysfunction-associated steatohepatitis (MASH) pathogenesis remains debated.
Hui-Ting Chen, Chen Huang, Jia-Wei Chen, Si-Qi Yang, Jie-Min Cheng, Yong-Qiang Li, Han-Qing Chen, Yong-Jian Zhou   +7 more
doaj   +2 more sources

Mechanism of Growth Regulation of Yeast Involving Hydrogen Sulfide From S-Propargyl-Cysteine Catalyzed by Cystathionine-γ-Lyase [PDF]

Frontiers in Microbiology, 2021
Pathogenic fungi are recognized as a progressive threat to humans, particularly those with the immunocompromised condition. The growth of fungi is controlled by several factors, one of which is signaling molecules, such as hydrogen sulfide (H2S), which ...
Zhongkai Gu, Yufan Sun, Feizhen Wu, Xiaomo Wu   +3 more
doaj   +2 more sources

Dual targeting of H₂S synthesizing enzymes; cystathionine β-synthase and cystathionine γ-lyase by miR-939-5p effectively curbs triple negative breast cancer. [PDF]

Heliyon, 2023
Nafea H, Youness RA, Dawoud A, Khater N, Manie T, Abdel-Kader R, Bourquin C, Szabo C, Gad MZ.   +8 more
europepmc   +2 more sources