Results 61 to 70 of about 12,014 (181)

Zofenopril Protects Against Myocardial Ischemia–Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide Bioavailability

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundZofenopril, a sulfhydrylated angiotensin‐converting enzyme inhibitor (ACEI), reduces mortality and morbidity in infarcted patients to a greater extent than do other ACEIs.
Erminia Donnarumma, Murtuza J. Ali, Amanda M. Rushing, Amy L. Scarborough, Jessica M. Bradley, Chelsea L. Organ, Kazi N. Islam, David J. Polhemus, Stefano Evangelista, Giuseppe Cirino, J. Stephen Jenkins, Rajan A. G. Patel, David J. Lefer, Traci T. Goodchild   +13 more
doaj   +1 more source

YALI0C22088g from Yarrowia lipolytica catalyses the conversion of l‐methionine into volatile organic sulfur‐containing compounds

Microbial Biotechnology, 2021
Summary The enzymatic conversion of l‐methionine (l‐Met) into volatile organic sulfur‐containing compounds (VOSCs) plays an important role in developing the characteristic aroma of foods.
Quan‐Lu Zhao, Zhu‐Lin Wang, Lan Yang, Sai Zhang, Kai‐Zhi Jia   +4 more
doaj   +1 more source

Tanshinone IIA Stimulates Cystathionine γ-Lyase Expression and Protects Endothelial Cells from Oxidative Injury

Antioxidants, 2021
Tanshinone IIA (Tan IIA), an active ingredient of Danshen, is a well-used drug to treat cardiovascular diseases. Currently, the mechanisms involved remain poorly understood.
Qiaojing Yan, Zhi-min Mao, Jingru Hong, Kun Gao, M. Niimi, T. Mitsui, Jian Yao   +6 more
semanticscholar   +1 more source

The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide (AP39) [PDF]

, 2014
Synthesis and bioavailability of the endogenous gasomediator hydrogen sulfide (H2S) is perturbed in many disease states, including those involving mitochondrial dysfunction.
Cai, Caliendo, Campolo, Chan, Chen, Cortese-Krott, Davidson, Fox, Fu, Halliwell, Kondo, Lavu, Li, Li, Li, Li, Liu, Liu, Liu, Mani, Merighi, Mkrtchyan, Murphy, Módis, Módis, Ohtsuki, Park, Paul, Perry, Robinson, Robinson, Shibuya, Shirozu, Smith, Suzuki, Szabo, Teng, Thorson, Thurnhofer, Vacek, Vandiver, Wallace, Wang, Wang, Watanabe, Weksler, Whiteman, Whiteman, Whiteman, Whiteman, Whiteman, Whiteman, Xu, Yang, Yin   +54 more
core   +1 more source

Propargylglycine inhibits hypotaurine/taurine synthesis and elevates cystathionine and homocysteine concentrations in primary mouse hepatocytes [PDF]

, 2015
Our investigation showed that hepatocytes isolated from cysteine dioxygenase knockout mice (Cdo1(−/−)) had lower levels of hypotaurine and taurine than Cdo1(+/+) hepatocytes. Interestingly, hypotaurine accumulates in cultured wild-type hepatocytes.
Halina Jurkowska, Heather B. Roman, Lawrence L. Hirschberger, Martha H. Stipanuk   +3 more
core   +1 more source

Inhibition of cystathionine-γ-lyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS [PDF]

, 2007
Oxidative stress has been implicated in the pathogenesis and progression of neurodegenerative disorders and antioxidants potentially have a major role in neuroprotection.
Diwakar, Latha, Ravindranath, Vijayalakshmi   +1 more
core   +1 more source

Hydrogen Sulfide Levels and Nuclear Factor‐Erythroid 2‐Related Factor 2 (NRF2) Activity Are Attenuated in the Setting of Critical Limb Ischemia (CLI)

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2015
Background Cystathionine γ‐lyase, cystathionine β‐synthase, and 3‐mercaptopyruvate sulfurtransferase are endogenous enzymatic sources of hydrogen sulfide (H2S).
Kazi N. Islam, David J. Polhemus, Erminia Donnarumma, Luke P. Brewster, David J. Lefer   +4 more
doaj   +1 more source

Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice

Redox Biology, 2017
No-caloric sweeteners, such as aspartame, are widely used in various food and beverages to prevent the increasing rates of obesity and diabetes mellitus, acting as tools in helping control caloric intake.
Isabela Finamor, Salvador Pérez, Caroline A. Bressan, Carlos E. Brenner, Sergio Rius-Pérez, Patricia C. Brittes, Gabriele Cheiran, Maria I. Rocha, Marcelo da Veiga, Juan Sastre, Maria A. Pavanato   +10 more
doaj   +1 more source

Dysregulation of cystathionine γ‐lyase promotes prostate cancer progression and metastasis

EMBO Reports, 2019
Hydrogen sulfide (H2S), an endogenous signaling gaseous molecule, is involved in various physiological activities, including vessel relaxation, regulation of cellular bioenergetics, inflammation, and angiogenesis.
Yi-Hsiang Wang, Jo-Ting Huang, Wen-ling Chen, Rong-Hsuan Wang, Ming-Chien Kao, Yan-Ru Pan, Shih-Hsuan Chan, K. Tsai, H. Kung, Kai-Ti Lin, Lu‐Hai Wang   +10 more
semanticscholar   +1 more source

Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF

JACC: Basic to Translational Science
Summary: Heart failure with preserved ejection fraction (HFpEF) presents significant treatment challenges. We assessed hydrogen sulfide (H2S) bioavailability in HFpEF patients and 2 animal models: the ''2-hit'' L-NAME + high-fat diet mouse model and ZSF1
Jake E. Doiron, PhD, Mahmoud H. Elbatreek, PhD, Huijing Xia, PhD, Xiaoman Yu, MS, Natalie D. Gehred, BA, Tatiana Gromova, BS, Jingshu Chen, PhD, Ian H. Driver, PhD, Naoto Muraoka, PhD, Martin Jensen, PhD, Smitha Shambhu, MS, W.H. Wilson Tang, MD, Kyle B. LaPenna, PhD, Thomas E. Sharp, III, PhD, Traci T. Goodchild, PhD, Ming Xian, PhD, Shi Xu, PhD, Heather Quiriarte, MS, Timothy D. Allerton, PhD, Alexia Zagouras, MD, MS, Jennifer Wilcox, BS, Sanjiv J. Shah, MD, Josef Pfeilschifter, PhD, Karl-Friedrich Beck, PhD, Thomas M. Vondriska, PhD, Zhen Li, PhD, David J. Lefer, PhD   +26 more
doaj   +1 more source