Results 71 to 80 of about 12,014 (181)

Hydrogen Sulfide Attenuates Lymphedema Via the Induction of Lymphangiogenesis Through a PI3K/Akt‐Dependent Mechanism

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Accumulating evidence suggests that hydrogen sulfide ( H2S ), an endogenously produced gaseous molecule, plays a critical role in the regulation of cardiovascular homeostasis. However, little is known about its role in lymphangiogenesis. Thus,
Junya Suzuki, Yuuki Shimizu, Takumi Hayashi, Yiyang Che, Zhongyue Pu, Kazuhito Tsuzuki, Shingo Narita, Rei Shibata, Isao Ishii, John W. Calvert, Toyoaki Murohara   +10 more
doaj   +1 more source

CD4+ T-Cell Endogenous Cystathionine γ Lyase–Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation

Circulation, 2020
Supplemental Digital Content is available in the text. Background: Hydrogen sulfide (H2S) has antihypertension and anti-inflammatory effects, and its endogenous-generation key enzyme cystathionine γ lyase (CSE) is expressed in CD4+ T cells.
Changting Cui, Jinghui Fan, Q. Zeng, Junyan Cai, Yongzeng Chen, Zhenzhen Chen, Wenjie Wang, Shuangyue Li, Qinghua Cui, Jichun Yang, Chao-shu Tang, Guoheng Xu, Junyan Cai, B. Geng   +13 more
semanticscholar   +1 more source

Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus. [PDF]

, 2016
Ergothioneine (EGT; 2-mercaptohistidine trimethylbetaine) is a trimethylated and sulphurised histidine derivative which exhibits antioxidant properties. Here we report that deletion of Aspergillus fumigatus egtA (AFUA_2G15650), which encodes a trimodular
A Braunshausen, A Palumbo, A Vit, A Vit, A Wallner, B Halliwell, C Burns, C Collins, C Davis, D Gründemann, DH Scharf, DJ Steenkamp, F Lessing, FP Seebeck, G Pontecorvo, G Rieder, GL Russo, GT Mashabela, GW Jones, H Haas, H Haas, H Oberegger, HS Spies, I Mouyna, J Aguirre, J Carlsson, J Cox, J Ey, KA O’Hanlon, KJ Sheridan, KV Goncharenko, L Gallagher, L Muszkieta, L Servillo, M Deiana, M Eisendle, M Schrettl, M Schrettl, M Schrettl, M Schrettl, M Thon, MH Bello, MH Bello, ML Nielsen, MR Ariyanayagam, NG Markova, OI Aruoma, PK Chang, RA Owens, RC Fahey, RN Vogt, S Carberry, S Paris, S Ravanel, S Sotgia, S Sotgia, SK Dolan, SS Spicer, T Hartmann, T Kubodera, T Pluskal, T Song, TP Holler, W Fang, Ö Sarikaya-Bayram   +64 more
core   +1 more source

Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics [PDF]

, 2016
Therapeutic manipulation of the gasotransmitter hydrogen sulfide (H(2)S) has recently been proposed as a novel targeted anticancer approach. Here we show that human lung adenocarcinoma tissue expresses high levels of hydrogen sulfide (H(2)S) producing ...
Druzhyna, Nadiya, Hellmich, Mark R., Marcatti, Michela, Nagy, Péter, Szabo, Csaba, Szczesny, Bartosz, Wiktorowicz, John E., Zatarain, John R.   +7 more
core   +1 more source

Influence of polymicroelement preparation Esmin on hydrogen sulfide levels and indices of pro- and antioxidant system in the rat myocardium of different age [PDF]

The Ukrainian Biochemical Journal, 2014
The influence of microelement preparation Esmin on hydrogen sulfide (H2S) levels, activity of H2S -producing enzymes and indices of pro-/antioxidant system in the myocardium of different age rats were investigated.
N. V. Zaichko, A. S. Olhovskiy, A. V. Melnik, P. A. Yurchenko, A. S. Grigorieva, N. F. Konahovich   +5 more
doaj   +1 more source

In Situ Synthesis of a Tumor Microenvironment‐Activated Radiosensitizing Cu2‐xS/LDH Probe for Photoacoustic Imaging‐Guided Radiotherapy

Advanced Science, EarlyView.
We reported a new kind of organic‐inorganic composite nanomaterial with excellent PA imaging performance after the in situ activation by hydrogen sulfide in colorectal cancer tissues, which was used for precise radiotherapy of colorectal cancer. It shows a great application potential for early diagnosis and treatment of tumor.
Kang Zhu, Qiaoqiao Wei, Ying Wu, Qingqing Li, Luntao Liu, Chunxiang Mo, Chuqiao Liu, Lichao Su, Jibin Song   +8 more
wiley   +1 more source

Production of hydrogen sulfide from D-cysteine and its therapeutic potential

Frontiers in Endocrinology, 2013
Accumulating evidence shows that H2S has physiological functions in various tissues and organs. It includes regulation of neuronal activity, vascular tension, a release of insulin, and protection of the heart, kidney and brain from ischemic insult. H2S
Norihiro eShibuya, Hideo eKimura
doaj   +1 more source

Quantification of Single‐Cell Cysteine Using an Electrochemical Nanosensor for Predicting Tumor Disulfidptosis Susceptibility

Advanced Science, EarlyView.
Cysteine attracts interest due to its unique electrochemical activity and emerging relationship with disulfidptosis. This study develops a new electrochemical nanosensor, which represents the first of its kind capable of detecting intracellular cysteine for various types of tumor cells and primary tumor cells in mice to evaluate disulfidptosis ...
Congcong Zhang, Xiangdi Zhang, Shushen Li, Yuyang Li, Bei Yuan, Mingshuang Zheng, Shuo Zhang, Fangping Yuan, Min Jia, Lixia Lu, Jun Zhou, Zhenguo Zhang, Xin Du   +12 more
wiley   +1 more source

Overview of Encapsulated Lysine and Methionine and Their Impacts on Transition Cow Performance and Health

Animal Research and One Health, EarlyView.
The transition period in dairy cows, spanning 3 weeks before and after calving, is a critical phase characterized by increased nutrient demands, reduced dry matter intake (DMI), and elevated risk of metabolic disorders such as negative nutrient balance (NNB), lipolysis, proteolysis, and oxidative stress.
Mohammed S. Seleem, Samy A. Elsaadawy, Zhaohai Wu, Lu Ma, Todd R. Callaway, Dengpan Bu   +5 more
wiley   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source