Results 91 to 100 of about 555,922 (178)

Hydrogen Sulfide Reduces Myeloid-Derived Suppressor Cell-Mediated Inflammatory Response in a Model of Helicobacter hepaticus-Induced Colitis

Frontiers in Immunology, 2018
Chronic inflammation contributes to tumor initiation in colitis-associated colorectal cancer (CRC). Indeed, inflammatory bowel disease (IBD) patients show an increased risk of developing CRC.
Paola De Cicco, Theodore Sanders, Giuseppe Cirino, Kevin J. Maloy, Angela Ianaro   +4 more
doaj   +1 more source

Caenorhabditis elegans and Drosophila melanogaster as Model Organisms in Biofactor Research

BioFactors, Volume 52, Issue 4, July/August 2026.
This review presents Caenorhabditis elegans and Drosophila melanogaster as powerful and ethically sound invertebrate model organisms that can be used to investigate nutritional science questions relating to biofactors. Such nutritional phenotyping studies can bridge the gap between in vitro studies and in vivo research in mammals.
Kai Lüersen, Thomas Roeder, Gerald Rimbach   +2 more
wiley   +1 more source

Cystathionine gamma-lyase/hydrogen sulfide system and glucose homeostasis [PDF]

, 2013
Research in the last twenty years has transformed the role of hydrogen sulfide (H2S) being perceived from a toxic gas to a gaso-transmitter with diverse physiological and pathological significance.
Zhang, Ling
core  

Determinants of Enzymatic Specificity in the Cys-Met Metabolism PLP-Dependent Enzyme Family: Crystal Structure of Cystathionine g-Lyase from Yeast and Intrafamiliar Structure Comparison

, 2003
The crystal structure of cystathionine [gamma]lyase (CGL) from yeast has been solved by molecular replacement at a resolution of 2.6 a. The molecule consists of 393 amino acid residues and one PLP moiety and is arranged in the crystal as a tetramer with ...
Laber, B., Wahl, M., Wahl, M.C., Huber, Robert, Steegborn, C., Clausen, T., Huber, R., Messerschmidt, A., Worbs, M.   +8 more
core   +1 more source

Inhibition of cystathionine-γ-lyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS

, 2007
Oxidative stress has been implicated in the pathogenesis and progression of neurodegenerative disorders and antioxidants potentially have a major role in neuroprotection.
Diwakar, Latha, Ravindranath, Vijayalakshmi   +1 more
core   +1 more source

Enhancing Postharvest Quality of Fresh-Cut Changgen Mushrooms by Exogenous L-Cysteine Treatment: Aspects of Accumulating Amino Acids, Triggering Energy Metabolism and Enhancing Endogenous H₂S Regulation

Foods
As a rare and functional edible mushroom, the market potential of ready-to-eat fresh-cut Changgen mushrooms (Oudemansiella raphanipes) is booming in developing countries.
Xingchi Ma, Tianhao Li, Weijian Mao, Yu Zhang, Haoran Liu, Wenwen Jiang, Yanan Sun, Hao Yu, Fansheng Cheng, Dan Zhu   +9 more
doaj   +1 more source

Procédés et compositions pour traiter des états associés à une hyperminéralisation

, 2022
patent submitter:Université de LausanneThe present disclosure relates to novel compounds that are activators of the cystathionine-gamma-lyase enzyme (CSE).
Nasi, Sonia, Riedl, Rainer, So, Alexander, Brand, Michael, Busso, Natalie, Gall, Flavio Max, Germann, Stefan   +6 more
core   +2 more sources

Preparation of pyrazole derivatives and compositions containing them for the treatment and prevention of diseases associated with hypermineralization

, 2021
patent submitter:Centre hospitalier universitaire vaudoisThe present disclosure relates to novel compounds that are activators of the cystathionine-gamma-lyase enzyme (CSE).
Nasi, Sonia, Riedl, Rainer, So, Alexander, Brand, Michael, Gall, Flavio, Busso, Natalie   +5 more
core   +2 more sources

[[alternative]]Dysregulation of cystathionine gamma-lyase promotes prostate cancer progression and metastasis

, 2019
[[abstract]]Hydrogen sulfide (H2 S), an endogenous signaling gaseous molecule, is involved in various physiological activities, including vessel relaxation, regulation of cellular bioenergetics, inflammation, and angiogenesis.
Wang, YH;Huang, JT;Chen, WL;Wang, RH;Kao, MC;Pan, YR;Chan, SH;Tsai, KW;Kung, HJ;Lin, KT;Wang, LH
core   +1 more source

Naphthyl-Substituted Indole and Pyrrole Carboxylic Acids as Effective Antibiotic Potentiators—Inhibitors of Bacterial Cystathionine γ-Lyase

, 2023
Over the past decades, the problem of bacterial resistance to most antibiotics has become a serious threat to patients’ survival. Nevertheless, antibiotics of a novel class have not been approved since the 1980s.
Mariia A. Kasatkina, Maxim A. Gureev, Nailya A. Zigangirova, Roman A. Ivanov, Andrey S. Kuzovlev, Sergey A. Silonov, Vasiliy V. Reshetnikov, Andrey V. Golovin, Yuri B. Porozov, Maxim A. Yunin, Mikhail V. Biryukov, Yulia E. Isakova, Mikhail D. Zybalov, Albina R. Belik   +13 more
core   +1 more source