The Chronic Elevated Consumption of <i>Hibiscus sabdariffa</i> Linnaeus Results in Kidney Damage Associated with Excess H<sub>2</sub>S. [PDF]
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In vivo characterization of the redox balance in IDH-wildtype glioblastomas: a J-difference edited MEGA-sLASER MRS study at 3T. [PDF]
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The Role of Hydrogen Sulfide in the Pathophysiology and Therapeutic Modulation of Hypertension: A Scoping Review. [PDF]
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Development of cystathionine gamma-lyase-specific microRNAs
Science Bulletin, 2015The gasotransmitter role of H2S in mammalian has been extensively studied, and cystathionine gamma-lyase (CSE) is the major H2S-producing enzyme in vascular system. Dysregulation of CSE/H2S system was found in various pathophysiological conditions.
Shuangshuang Li, Guangdong Yang
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Hydrogen sulfide (H2S) is an endogenous neuromodulator produced mainly by the enzyme cystathionine gamma-lyase (CSE) in peripheral tissues. A pronociceptive role of endogenously produced H2S has been previously reported by our group in a model of orofacial inflammatory pain.
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Enzymatic degradation of elastin by matrix metalloproteinases (MMPs) leads to the permanent dilation of aortic wall and constitutes the most prominent characters of aortic aneurysm and aging-related medial degeneration. Hydrogen sulfide (H2S) as a gasotransmitter exhibits a wide variety of cardio-protective functions through its anti-inflammatory and ...
Yuehong Wang +2 more
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Cystathionine gamma-lyase deficiency exaggerates diethylnitrosamine-induced liver damage in mice
Nitric Oxide - Biology and ChemistryCystathionine gamma-lyase (CSE) is a key enzyme in reverse transsulfuration pathway and contributes to the majority of H2S generation in liver tissues via cysteine metabolism. Dysfunction of the CSE/H2S system is linked to both chronic and acute liver damage.
Guangdong Yang
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Is cystathionine gamma-lyase protein expressed in the heart?
Biochemical and Biophysical Research Communications, 2012Hydrogen sulfide (H(2)S) has emerged as an important gasotransmitter, offering protection against ischemia-reperfusion damage to the heart. Cystathionine gamma-lyase (CSE) is believed to be the major H(2)S-generating enzyme in the heart. Quite contrary to the general contemplation, CSE protein in cardiac tissues has not been convincingly detected and ...
Ming, Fu +3 more
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Age-Dependent Allergic Asthma Development and Cystathionine Gamma-Lyase Deficiency
Antioxidants & Redox Signaling, 2017Aims: The pathogenic mechanisms for the higher prevalence of allergic asthma in children than in adults have not been settled. The aim of the present study is to examine whether the age-dependent development of allergic asthma is caused by age-dependent expression of cystathionine gamma ...
Peipei, Wang +6 more
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Cystathionine gamma‐lyase aggravates periodontal damage in traumatic occlusion mouse models
Journal of Periodontal Research, 2020AbstractBackground and objectiveThough impacts of traumatic occlusion (TO) on periodontal tissues and roles of cystathionine γ‐lyase (Cth) gene in the regulation of bone homeostasis have been studied by many, no consensus has been reached so far on whether TO deteriorates the periodontium and precise roles of Cth in occlusal trauma.
Liyuan Chen, Caizhu Lu, Yongmei Hua
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