Results 11 to 20 of about 1,391 (117)

Total sulfane sulfur bioavailability reflects ethnic and gender disparities in cardiovascular disease [PDF]

Redox Biology, 2018
Hydrogen sulfide (H2S) has emerged as an important physiological and pathophysiological signaling molecule in the cardiovascular system influencing vascular tone, cytoprotective responses, redox reactions, vascular adaptation, and mitochondrial ...
Saurabh Rajpal, Pavan Katikaneni, Matthew Deshotels, Sibile Pardue, John Glawe, Xinggui Shen, Nuri Akkus, Kalgi Modi, Ruchi Bhandari, Paari Dominic, Pratap Reddy, Gopi K. Kolluru, Christopher G. Kevil   +12 more
doaj   +4 more sources

Cystathionine gamma-lyase-mediated hypoxia inducible factor 1-alpha expression drives clear cell ovarian cancer progression. [PDF]

J Pathol
Abstract Clear cell ovarian cancer (CCOC) is the second most common ovarian cancer subtype, accounting for 5%–11% of ovarian cancers in North America. Late‐stage CCOC is associated with a worse prognosis compared to other ovarian cancer histotypes, a challenge that has seen limited progress in recent decades.
El-Naggar AM, Li Y, Turgu B, Ding Y, Wei L, Chen SY, Trigo-Gonzalez G, Kalantari F, Vallejos R, Lynch B, Senz J, Lum A, Douglas JM, Salamanca C, Thornton S, Qin Y, Parmar K, Spencer SE, Leung S, Woo MMM, Yong PJ, Zhang HF, Hughes CS, Negri GL, Wang Y, Morin GB, Sorensen PH, Huntsman DG.   +27 more
europepmc   +2 more sources

Hydrogen Sulfide Protects Erectile Function Through Stimulation of Antioxidant Defense in the Corpus Cavernosum: Insights From SG1002 Administration and Cystathionine γ-Lyase Knockout. [PDF]

FASEB J
Chronic consumption of a western diet suppressed corpus cavernosum cystathionine γ‐lyase (CSE) protein content and H2S production and was associated with elevated penile reactive oxygen species (ROS) levels and impaired erectile function. CSE knockout mice demonstrate impaired erectile function, elevated penile ROS levels, and suppressed corpus ...
Azeez TA, Rhein PR, Pierre CJ, Ihrig CM, La Favor JD.   +4 more
europepmc   +2 more sources

CSE/H₂S/SESN2 Signalling Mediates the Protective Effect of Exercise Against Immobilization-Induced Muscle Atrophy in Mice. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Hydrogen sulphide (H2S), a gasotransmitter synthesized by cystathionine‐γ‐lyase (CSE), exhibits antioxidant properties and may mimic exercise‐induced muscle protection. However, its mechanistic role in muscle atrophy and exercise intervention remains unclear.
Li X, Huang Y, Yang X, Liu S, Niu Y, Fu L.   +5 more
europepmc   +2 more sources

Hydrogen sulfide pathway and skeletal muscle: an introductory review. [PDF]

, 2018
The presence of the H2 S pathway in skeletal muscle (SKM) has recently been established. SKM expresses the three constitutive H2 S-generating enzymes in animals and humans, and it actively produces H2 S.
Armogida Chiara, Bucci Mariarosaria, Vellecco Valentina   +2 more
core   +4 more sources

Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity [PDF]

, 2020
The red-crowned crane (Grus japonensis) is an endangered, large-bodied crane native to East Asia. It is a traditional symbol of longevity and its long lifespan has been confirmed both in captivity and in the wild.
Bhak, Jong, Blazyte, Asta, Cho, Yun Sung, Choi, Jae-Pil, Chung, Oksung, Edwards, Jeremy S., Jeon, Sungwon, Jho, Sungwoong, Jun, JeHoon, Kim, Hak-Min, Kim, Jungeun, Lee, HyeJin, Lim, Jeongheui, Paek, Woon Kee, Weber, Jessica A.   +14 more
core   +1 more source

Functional characterization and structure-guided mutational analysis of the transsulfuration enzyme cystathionine γ-lyase from toxoplasma gondii [PDF]

, 2018
Sulfur-containing amino acids play essential roles in many organisms. The protozoan parasite Toxoplasma gondii includes the genes for cystathionine β-synthase and cystathionine γ-lyase (TgCGL), as well as for cysteine synthase, which are crucial enzymes ...
Astegno, A., Dominici, P, Fruncillo, S, Janson, G, Maresi, E, Paiardini, A, Vallone, R   +6 more
core   +2 more sources

Role of Cystathionine Gamma-Lyase in Immediate Renal Impairment and Inflammatory Response in Acute Ischemic Kidney Injury [PDF]

, 2016
Hydrogen sulfide (H2S) is known to act protectively during renal ischemia/reperfusion injury (IRI). However, the role of the endogenous H2S in acute kidney injury (AKI) is largely unclear.
Anders, Juliane, Balogh, Andras, Filipovic, Milos R., Gollasch, Maik, Ishii, Isao, Kassmann, Mario, Kramer, Stephanie, Marko, Lajos, Mueller, Dominik N., N'diaye, Gabriele, Park, Joon-Keun, Przybyl, Lukasz, Szijarto, Istvan A.   +12 more
core   +2 more sources

Cystathionine Gamma Lyase Is Regulated by Flow and Controls Smooth Muscle Migration in Human Saphenous Vein. [PDF]

, 2023
The saphenous vein is the conduit of choice for bypass grafting. Unfortunately, the hemodynamic stress associated with the arterial environment of the bypass vein graft leads to the development of intimal hyperplasia (IH), an excessive cellular growth ...
Lambelet, M., Urfer, S.
core   +1 more source

Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice [PDF]

, 2017
Background: The phosphorylation of eukaryotic initiation factor 2 (p-eIF2) during dietary amino acid insufficiency reduces protein synthesis and alters gene expression via the integrated stress response (ISR).Objective: We explored whether a Met ...
Anthony, Tracy G., Bargoud, Albert R., Gettys, Thomas W., Hamilton, Karyn L., Jonsson, William O., Kimball, Scot R., Miller, Benjamin F., Mirek, Emily T., Peelor, Frederick F., III, Pettit, Ashley P., Wang, Yongping, Wek, Ronald C.   +11 more
core   +1 more source