Results 1 to 10 of about 55,122 (162)

A Novel Cystatin Gene from Sea Cucumber (Apostichopus japonicus): Characterization and Comparative Expression with Cathepsin L During Early Stage of Hypoxic Exposure-Induced Autolysis [PDF]

Foods
Autolysis in sea cucumber has long been a threat to raw material storage and product processing. The involvement of endogenous cysteine protease in sea cucumber autolysis has been proved extendedly.
Siyu Yao, Rui Zhang, Siyuan Ma, Ting Zhao, Qinhao Liu, Lin Zhu, Chang Liu, Liming Sun, Ming Du   +8 more
doaj   +2 more sources

Estimated glomerular filtration rate is a poor predictor of the concentration of middle molecular weight uremic solutes in chronic kidney disease [PDF]

, 2012
Background: Uremic solute concentration increases as Glomerular Filtration Rate (GFR) declines. Weak associations were demonstrated between estimated GFR (eGFR) and the concentrations of several small water-soluble and protein-bound uremic solutes ...
Barreto, Daniela V, Barreto, Fellype C, Eloot, Sunny, Glorieux, Griet, Lemke, Horst D, Lenglet, Aurélie, Liabeuf, Sophie, Massy, Ziad A, Neirynck, Nathalie, Vanholder, Raymond   +9 more
core   +23 more sources

Immunomics-Guided Antigen Discovery for Praziquantel-Induced Vaccination in Urogenital Human Schistosomiasis

Frontiers in Immunology, 2021
Despite the enormous morbidity attributed to schistosomiasis, there is still no vaccine to combat the disease for the hundreds of millions of infected people.
Mark S. Pearson, Bemnet A. Tedla, Luke Becker, Rie Nakajima, Al Jasinskas, Takafira Mduluza, Takafira Mduluza, Francisca Mutapi, Francisca Mutapi, Claude Oeuvray, Beatrice Greco, Javier Sotillo, Javier Sotillo, Philip L. Felgner, Alex Loukas   +14 more
doaj   +1 more source

SARS‐CoV‐2 infection results in upregulation of Plasminogen Activator Inhibitor‐1 and Neuroserpin in the lungs, and an increase in fibrinolysis inhibitors associated with disease severity

eJHaem, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection results in coagulation activation although it is usually not associated with consumption coagulopathy. D‐dimers are also commonly elevated despite systemic hypofibrinolysis.
Kevin H. Toomer, Gloria F. Gerber, Yifan Zhang, Laetitia Daou, Michael Tushek, Jody E. Hooper, Ivo M. B. Francischetti   +6 more
doaj   +1 more source

The Role of Exosomes in the Pathophysiology of Chronic Rhinosinusitis

Frontiers in Cellular and Infection Microbiology, 2022
Non-invasive biomarker analysis has made repetitive and painless sampling over time possible. Exosomes are being released from a parent cell and their cargo mirrors the cell micromilieu of the parent cell. Therefore, exosomes are promising surrogates for
Sarina K. Mueller
doaj   +1 more source

Altered Expression of Peroxiredoxins in Mouse Model of Progressive Myoclonus Epilepsy upon LPS-Induced Neuroinflammation

Antioxidants, 2021
Stefin B (cystatin B) is an inhibitor of endo-lysosomal cysteine cathepsin, and the loss-of-function mutations in the stefin B gene were reported in patients with Unverricht–Lundborg disease (EPM1), a form of progressive myoclonus epilepsy.
Mojca Trstenjak Prebanda, Petra Matjan-Štefin, Boris Turk, Nataša Kopitar-Jerala   +3 more
doaj   +1 more source

Therapeutic Effect of Schistosoma japonicum Cystatin on Atherosclerotic Renal Damage

Frontiers in Cell and Developmental Biology, 2021
Atherosclerosis is a chronic inflammation of the arterial vessel wall driven by lipid metabolism disorders. Although helminthic infection and their derivatives have been identified to attenuate the chronic inflammatory diseases, the immunomodulatory ...
Huijuan Yang, Huijuan Yang, Hongqi Li, Weidong Chen, Zhijie Mei, Yuan Yuan, Yuan Yuan, Xiaoli Wang, Xiaoli Wang, Liang Chu, Yu Xu, Yu Xu, Yan Sun, Yan Sun, Dingru Li, Dingru Li, Hongyu Gao, Hongyu Gao, Bin Zhan, Huihui Li, Huihui Li, Xiaodi Yang, Xiaodi Yang   +22 more
doaj   +1 more source

Salivary proteome profile of women during fertile phase of menstrual cycle as characterized by mass spectrometry

Gynecology and Minimally Invasive Therapy, 2021
Objectives: Ovulation is such a critical physiological process that its noninvasive detection based on salivary constituents has several advantages in humans.
Ganesan Saibaba, Durairaj Rajesh, Subramanian Muthukumar, Ganesan Sathiyanarayanan, Archunan Priya Aarthy, Govindaraju Archunan   +5 more
doaj   +1 more source

Comparative transcriptomic analysis-based identification of the regulation of foreign proteins with different stabilities expressed in Pichia pastoris

Frontiers in Microbiology, 2022
IntroductionThe industrial yeast Pichia pastoris is widely used as a cell factory to produce proteins, chemicals and advanced biofuels. We have previously constructed P. pastoris strains that overexpress protein disulfide isomerase (PDI), which is a kind
Tingting Niu, Yi Cui, Xu Shan, Shuzhen Qin, Xuejie Zhou, Rui Wang, Alan Chang, Nan Ma, Jingjing Jing, Jianwei He   +9 more
doaj   +1 more source

Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of ‘Papain Superfamily’ Cysteine Proteases

Pharmaceuticals, 2020
Clan C1A or ‘papain superfamily’ cysteine proteases are key players in many important physiological processes and diseases in most living systems. Novel approaches towards the development of their inhibitors can open new avenues in translational medicine.
Manasi Mishra, Vigyasa Singh, Meenakshi B. Tellis, Rakesh S. Joshi, Shailja Singh   +4 more
doaj   +1 more source