Results 121 to 130 of about 55,204 (241)

Trends in resource utilization for new‐onset psychosis hospitalizations at children's hospitals

Journal of Hospital Medicine, EarlyView.
Abstract Background Children with new‐onset psychosis often require hospitalization for medical evaluation. Objectives The goal of this study was to assess variations in the management of children with new‐onset psychosis and characterize trends in resource utilization.
Ankita Gupta, Matt Hall, Benjamin Masserano, Averi Wilson, Katherine Johnson, Clifford Chen, Lasya Challa, Harita Katragadda, Vineeta Mittal   +8 more
wiley   +1 more source

Impact of smoking habit on the subgingival proteome in patients with periodontitis

Journal of Periodontology, Volume 96, Issue 3, Page 217-229, March 2025.
Abstract Background Few investigations evaluated smoking's impact on the periodontal proteome. Therefore, this study aimed to analyse the influence of tobacco on the overall periodontal proteome and the differential expression of gingival crevicular fluid (GCF) proteins using sequential window acquisition of all theoretical mass spectra (SWATH‐MS ...
Triana Blanco‐Pintos, Alba Regueira‐Iglesias, Iryna Kuz, Alba Sánchez‐Barco, Noelia Seijas‐Otero, María del Pilar Chantada‐Vázquez, Carlos Balsa‐Castro, Inmaculada Tomás   +7 more
wiley   +1 more source

Dihydromyricetin Promotes Glucagon‐Like Peptide‐1 Secretion and Improves Insulin Resistance by Modulation of the Gut Microbiota‐CDCA Pathway

Molecular Nutrition &Food Research, Volume 69, Issue 8, April 2025.
Dihydromyricetin (DHM) administration improved insulin resistance in HFD‐induced mice through the increased serum GLP‐1 level. This benefits was mediated by the decreased degradation of GLP‐1 associated with the reduced proportion of TCRαβ+ CD8αβ+ IELs and decreased expression of CD26/DPP‐4 in IELs, as well as the increased GLP‐1 secretion by ...
Pengfei Li, Yong Zhang, Hedong Lang, Pengfei Hou, Yu Yao, Ruiliang Zhang, Xiaolan Wang, Qianyong Zhang, Mantian Mi, Long Yi   +9 more
wiley   +1 more source

Evaluation of Pediatric and Young Adult Cancer Survivors at Risk of Long‐Term Kidney Complications

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nephrotoxic chemotherapy, nephrectomy, abdominal radiotherapy exposure, and the presence of kidney or pelvic tumors are risk factors associated with long‐term kidney complications. This study aimed to determine the prevalence of long‐term kidney complications in patients who survived pediatric and young adult cancer and were exposed
Ahmed Zeid, Sara Delap, Claudia Mosquera Vasquez, Randal S. Olshefski, Joseph R. Stanek, Lory Guthrie, Diana Zepeda‐Orozco   +6 more
wiley   +1 more source

Effect of creatine monohydrate on motor function in children with facioscapulohumeral muscular dystrophy: A multicenter, randomized, double‐blind placebo‐controlled crossover trial

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Abstract Background Facioscapulohumeral muscular dystrophy (FSHD) is a rare, progressive muscle disease with no available disease‐modifying therapy. Creatine monohydrate (CrM) has been shown to improve muscle strength in individuals with muscular dystrophies but has not been tested in young people with FSHD.
Ian R. Woodcock, Katy de Valle, Anita Cairns, Zoe E. Davidson, Michael Kean, Nisha Varma, Anneke Grobler, David Metz, Kate Carroll, Nuran Dilek, Chad Heatwole, Monique M. Ryan, Martin B. Delatycki, Eppie M. Yiu   +13 more
wiley   +1 more source

The Omics‐Driven Machine Learning Path to Cost‐Effective Precision Medicine in Chronic Kidney Disease

PROTEOMICS, EarlyView.
ABSTRACT Chronic kidney disease (CKD) poses a significant and growing global health challenge, making early detection and slowing disease progression essential for improving patient outcomes. Traditional diagnostic methods such as glomerular filtration rate and proteinuria are insufficient to capture the complexity of CKD.
Marta B. Lopes, Roberta Coletti, Flore Duranton, Griet Glorieux, Mayra Alejandra Jaimes Campos, Julie Klein, Matthias Ley, Paul Perco, Alexia Sampri, Aviad Tur‐Sinai   +9 more
wiley   +1 more source

Increased Cystatin C in Astrocytes of Transgenic Mice Expressing the K670N-M671L Mutation of the Amyloid Precursor Protein and Deposition in Brain Amyloid Plaques

Neurobiology of Disease, 2001
Cystatin C is an essential secretory cofactor for neurogenesis with potent protease inhibitor activities. Polymorphisms of cystatin C are genetically associated with Alzheimer's disease (AD), and the L68Q mutation causes hereditary cerebral hemorrhage ...
Tiana Steinhoff, Eva Moritz, M.Axel Wollmer, M.Hasan Mohajeri, Stefan Kins, Roger M. Nitsch   +5 more
doaj  

Editorial Comment on “Zinner Syndrome Presenting With Chronic Pelvic Pain and Ejaculatory Dysfunction” From Dr. Sourav and Dr. Tweheyo

IJU Case Reports, EarlyView.
Sourav Sudan, Tweheyo Ronald
wiley   +1 more source

A Population Pharmacokinetic Model to Inform Extension of the Eteplirsen Dosing Regimen Across the Broad DMD Population

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 5, Page 891-903, May 2025.
ABSTRACT Duchenne muscular dystrophy (DMD) is characterized by progressive, irreversible muscle damage that usually leads to premature death from cardiac or respiratory failure. Eteplirsen is a phosphorodiamidate morpholino oligomer and the first antisense oligonucleotide (ASO) approved for the treatment of patients with exon 51 skip‐amenable DMD. This
Yogesh Patel, Larry Orogun, Nicole Yocum, Louise R. Rodino‐Klapac, Lilly East   +4 more
wiley   +1 more source

The effectiveness and safety of azvudine treatment in COVID‐19 patients with kidney disease based on a multicenter retrospective cohort study

VIEW, EarlyView.
A retrospective, multicenter cohort study was conducted across nine hospitals in Henan Province, aiming to evaluate the efficacy and safety of azvudine in hospitalized COVID‐19 patients with kidney disease. Through the application of Kaplan‒Meier and multivariate Cox regression analyses, it was found that azvudine may have potential effects in reducing
Bo Yu, Mengzhao Yang, Jia Yu, Daming Wang, Hong Luo, Ming Cheng, Shixi Zhang, Guotao Li, Ling Wang, Guowu Qian, Donghua Zhang, Silin Li, Zhigang Ren, Quancheng Kan   +13 more
wiley   +1 more source