Results 11 to 20 of about 41,311 (257)

Altered Expression of Peroxiredoxins in Mouse Model of Progressive Myoclonus Epilepsy upon LPS-Induced Neuroinflammation

Antioxidants, 2021
Stefin B (cystatin B) is an inhibitor of endo-lysosomal cysteine cathepsin, and the loss-of-function mutations in the stefin B gene were reported in patients with Unverricht–Lundborg disease (EPM1), a form of progressive myoclonus epilepsy.
Mojca Trstenjak Prebanda, Petra Matjan-Štefin, Boris Turk, Nataša Kopitar-Jerala   +3 more
doaj   +1 more source

SARS‐CoV‐2 infection results in upregulation of Plasminogen Activator Inhibitor‐1 and Neuroserpin in the lungs, and an increase in fibrinolysis inhibitors associated with disease severity

eJHaem, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection results in coagulation activation although it is usually not associated with consumption coagulopathy. D‐dimers are also commonly elevated despite systemic hypofibrinolysis.
Kevin H. Toomer, Gloria F. Gerber, Yifan Zhang, Laetitia Daou, Michael Tushek, Jody E. Hooper, Ivo M. B. Francischetti   +6 more
doaj   +1 more source

Cystatin Superfamily [PDF]

Journal of Health Care for the Poor and Underserved, 2010
Cystatins, the classical inhibitors of C1 cysteine proteinases, have been extensively studied and reviewed in the literature. Over the last 20 years, however, proteins containing cystatin domains but lacking protease inhibitory activities have been identified, and most likely more will be described in the near future.
Josiah, Ochieng, Gautam, Chaudhuri
openaire   +2 more sources

Discordance Between Creatinine-Based and Cystatin C–Based Estimated GFR: Interpretation According to Performance Compared to Measured GFRPlain-Language Summary

Kidney Medicine, 2023
Rationale & Objective: Use of cystatin C in addition to creatinine to estimate glomerular filtration rate (estimated glomerular filtration rate based on cystatin C [eGFRcys] and estimated glomerular filtration rate based on creatinine [eGFRcr ...
Yeli Wang, Ogechi M. Adingwupu, Michael G. Shlipak, Alessandro Doria, Michelle M. Estrella, Marc Froissart, Vilmundur Gudnason, Anders Grubb, Roberto Kalil, Michael Mauer, Peter Rossing, Jesse Seegmiller, Josef Coresh, Andrew S. Levey, Lesley A. Inker   +14 more
doaj   +1 more source

The Role of Exosomes in the Pathophysiology of Chronic Rhinosinusitis

Frontiers in Cellular and Infection Microbiology, 2022
Non-invasive biomarker analysis has made repetitive and painless sampling over time possible. Exosomes are being released from a parent cell and their cargo mirrors the cell micromilieu of the parent cell. Therefore, exosomes are promising surrogates for
Sarina K. Mueller
doaj   +1 more source

Immunomics-Guided Antigen Discovery for Praziquantel-Induced Vaccination in Urogenital Human Schistosomiasis

Frontiers in Immunology, 2021
Despite the enormous morbidity attributed to schistosomiasis, there is still no vaccine to combat the disease for the hundreds of millions of infected people.
Mark S. Pearson, Bemnet A. Tedla, Luke Becker, Rie Nakajima, Al Jasinskas, Takafira Mduluza, Takafira Mduluza, Francisca Mutapi, Francisca Mutapi, Claude Oeuvray, Beatrice Greco, Javier Sotillo, Javier Sotillo, Philip L. Felgner, Alex Loukas   +14 more
doaj   +1 more source

Therapeutic Effect of Schistosoma japonicum Cystatin on Atherosclerotic Renal Damage

Frontiers in Cell and Developmental Biology, 2021
Atherosclerosis is a chronic inflammation of the arterial vessel wall driven by lipid metabolism disorders. Although helminthic infection and their derivatives have been identified to attenuate the chronic inflammatory diseases, the immunomodulatory ...
Huijuan Yang, Huijuan Yang, Hongqi Li, Weidong Chen, Zhijie Mei, Yuan Yuan, Yuan Yuan, Xiaoli Wang, Xiaoli Wang, Liang Chu, Yu Xu, Yu Xu, Yan Sun, Yan Sun, Dingru Li, Dingru Li, Hongyu Gao, Hongyu Gao, Bin Zhan, Huihui Li, Huihui Li, Xiaodi Yang, Xiaodi Yang   +22 more
doaj   +1 more source

Salivary proteome profile of women during fertile phase of menstrual cycle as characterized by mass spectrometry

Gynecology and Minimally Invasive Therapy, 2021
Objectives: Ovulation is such a critical physiological process that its noninvasive detection based on salivary constituents has several advantages in humans.
Ganesan Saibaba, Durairaj Rajesh, Subramanian Muthukumar, Ganesan Sathiyanarayanan, Archunan Priya Aarthy, Govindaraju Archunan   +5 more
doaj   +1 more source

Characterization of a Novel Cysteine Protease Inhibitor from Poultry Red Mites: Potential Vaccine for Chickens

Vaccines, 2021
Poultry red mite (PRM; Dermanyssus gallinae) is a hazardous, blood-sucking ectoparasite of birds that constitutes a threat to poultry farming worldwide.
Sotaro Fujisawa, Shiro Murata, Masayoshi Isezaki, Takuma Ariizumi, Takumi Sato, Eiji Oishi, Akira Taneno, Naoya Maekawa, Tomohiro Okagawa, Osamu Ichii, Satoru Konnai, Kazuhiko Ohashi   +11 more
doaj   +1 more source

Stefin B Inhibits NLRP3 Inflammasome Activation via AMPK/mTOR Signalling

Cells, 2023
Stefin B (cystatin B) is an inhibitor of lysosomal and nuclear cysteine cathepsins. The gene for stefin B is located on human chromosome 21 and its expression is upregulated in the brains of individuals with Down syndrome.
Mojca Trstenjak-Prebanda, Monika Biasizzo, Klemen Dolinar, Sergej Pirkmajer, Boris Turk, Veronique Brault, Yann Herault, Nataša Kopitar-Jerala   +7 more
doaj   +1 more source