Stefin B Inhibits NLRP3 Inflammasome Activation via AMPK/mTOR Signalling
Cells, 2023 Stefin B (cystatin B) is an inhibitor of lysosomal and nuclear cysteine cathepsins. The gene for stefin B is located on human chromosome 21 and its expression is upregulated in the brains of individuals with Down syndrome.
Mojca Trstenjak-Prebanda +7 more
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Vaccines, 2021 Poultry red mite (PRM; Dermanyssus gallinae) is a hazardous, blood-sucking ectoparasite of birds that constitutes a threat to poultry farming worldwide.
Sotaro Fujisawa +11 more
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Cystatins as calpain inhibitors: Engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of μ-calpain [PDF]
, 2001 Within the cystatin superfamily, only kininogen domain 2 (KD2) is able to inhibit μ- and m-calpain. In an attempt to elucidate the structural requirements of cystatins for calpain inhibition, we constructed recombinant hybrids of human stefin B (an ...
Anastasi A. +14 more
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Prognostic importance of emerging cardiac, inflammatory, and renal biomarkers in chronic heart failure patients with reduced ejection fraction and anaemia: RED-HF study [PDF]
, 2018 Aims: To test the prognostic value of emerging biomarkers in the Reduction of Events by Darbepoetin Alfa in Heart Failure (RED-HF) trial. Methods and results: Circulating cardiac [N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high ...
Alehagen +34 more
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Upregulation of Mitochondrial Redox Sensitive Proteins in LPS-Treated Stefin B-Deficient Macrophages
Cells, 2019 Stefin B (cystatin B) is an intracellular inhibitor of cysteine cathepsins and mutations in the stefin B gene, resulting in the development of Unverricht−Lundborg disease, which is a form of myoclonic epilepsy. It was suggested that a key mechanism
Mojca Trstenjak Prebanda +3 more
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Biotechnology & Biotechnological Equipment, 2023 Cystatin plays a crucial role in immune evasion by parasites. It regulates diverse immune response processes, such as antigen presentation, cytokine and NO production, and phagocytosis.
Lin Huang +3 more
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Estimated glomerular filtration rate correlates poorly with four-hour creatinine clearance in critically ill patients with acute kidney injury. [PDF]
, 2013 Introduction. RIFLE and AKIN provide a standardised classification of acute kidney injury (AKI), but their categorical rather than continuous nature restricts their use to a research tool. A more accurate real-time description of renal function in AKI is
Kirwan, CJ, Macphee, IA, Philips, BJ
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Glomerular Filtration Rate Estimation Based on Cystatin C Formulas among Neonates [PDF]
Iranian Journal of Neonatology, 2021 Background: Glomerular filtration rate (GFR) is the best indicator to assess renal function; however, it is difficult to perform it, especially in neonates.
Nasrin Khalesi +7 more
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Renal Hyperfiltration and the Development of Microalbuminuria in Type 1 Diabetes [PDF]
, 2009 OBJECTIVE: The purpose of this study was to examine prospectively whether renal hyperfiltration is associated with the development of microalbuminuria in patients with type 1 diabetes, after taking into account known risk factors.
Aschengrau, Ann +6 more
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Pharmaceuticals, 2019 In keeping with recent developments in basic research; the importance of the Cathepsins as targets in cancer therapy have taken on increasing importance and given rise to a number of key areas of interest in the clinical setting.
Surinder M. Soond +3 more
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