Results 81 to 90 of about 55,204 (241)

First‐in‐Human Phase 1 Study to Evaluate the Clinical Pharmacology Properties of RBN‐3143, a Novel Inhibitor of Mono‐Adenosine Diphosphate Ribosyltransferase‐PARP14

Clinical Pharmacology in Drug Development, EarlyView.
Abstract RBN‐3143 is an inhibitor of PARP14 in development for inflammatory diseases. Multiple assessments were conducted to evaluate the clinical pharmacology properties of RBN‐3134. A randomized, double‐blind, placebo‐controlled study assigned healthy volunteers (HVs) to single ascending doses (SADs) (25‐1000 mg) or multiple ascending doses (MADs ...
Thomas M. Polasek, Alexandra Cole, Viviana Bozón, Erika Manyak, Jonathan Novak, Barbara Yang, Briohny A. Johnston, Sudha Parasuraman, Kushal J. Paneliya, Virna Schuck   +9 more
wiley   +1 more source

Molecular determinants of acute kidney injury [PDF]

, 2015
BACKGROUND: Acute kidney injury (AKI) is a condition that leads to a rapid deterioration of renal function associated with impairment to maintain electrolyte and acid balance, and, if left untreated, ultimately irreversible kidney damage and renal ...
Human, Christin, Husi, Holger
core   +2 more sources

A Joint Pharmacometric Model of Iohexol and Creatinine Administered through a Meat Meal to Assess GFR and Renal OCT2/MATE Activity

Clinical Pharmacology &Therapeutics, EarlyView.
Accurately assessing glomerular filtration rate (GFR) from plasma creatinine concentrations is challenging in patients with unstable renal function. This study aimed to refine the understanding of creatinine kinetics for more reliable assessments of GFR and net creatinine tubular secretion (nCTS) via OCT2/MATE in humans.
Zhendong Chen, Qian Dong, Charalambos Dokos, Jana Boland, Uwe Fuhr, Max Taubert   +5 more
wiley   +1 more source

Feasibility of replacing ^99mTc-DTPA GFR measurements with eGFR from cystatin C in individuals with spinal cord injuries. [PDF]

Physiol Rep
Abstract In individuals with spinal cord injury (SCI) and neurogenic bladder dysfunction, guidelines recommend regular monitoring of kidney function by measuring the glomerular filtration rate using an externally administered filtration markers such as 99mTc‐DTPA, since creatinine‐based eGFR models are inaccurate due to lower muscle mass in these ...
Kristensen T, Oturai PS, Haddock BT, Biering-Sørensen F, Kruuse C, Andersen UB.   +5 more
europepmc   +2 more sources

Helminths in the gastrointestinal tract 1 as modulators of immunity and pathology [PDF]

, 2017
Helminth parasites are highly prevalent in many low- and middle-income countries, in which inflammatory bowel disease and other immunopathologies are less frequent than in the developed world.
Fleming, John O., Maizels, Richard, Varyani, Fumi   +2 more
core   +1 more source

Analysis of the usefulness and benefits of ultrafiltration in cardiorenal syndrome: A systematic review

ESC Heart Failure, Volume 12, Issue 2, Page 1194-1202, April 2025.
Abstract Aims Cardiac decompensation in cardiorenal syndrome (CRS) results in systemic congestion usually treated with diuretics. When despite high doses of diuretics, response is poor, ultrafiltration (UF) appears to be a useful and safe technique.
Borja Guerrero Cervera, Raquel López‐Vilella, Víctor Donoso Trenado, María Peris‐Fernández, Paula Carmona, Amparo Soldevila, Sergi Tormo, Ramón Devesa, María Jesús Montero Hernández, Luis Martínez Dolz, Julio Hernández Jaras, Pilar Sánchez‐Pérez, Luis Almenar‐Bonet   +12 more
wiley   +1 more source

Design and rationale of the eLym™ System for Decompensation of Excess Lymphatic Fluid via the Thoracic Duct in Acute Heart Failure (DELTA‐HF)

ESC Heart Failure, Volume 12, Issue 3, Page 1719-1726, June 2025.
Abstract Aims The interstitial space is the major compartment in which the excess fluid is located, forming peripheral congestion in acute decompensated heart failure (ADHF). The lymphatic system is responsible for the constant drainage of the compartment.
Jan Biegus, JoAnn Lindenfeld, G. Michael Felker, George Bakris, Michael Jonas, Anuradha Lala, Zviad Kereselidze, George Khabeishvili, Irakli Gogorishvili, Julio Núñez, Antoni Bayés‐Genís, Piotr Ponikowski, William T. Abraham   +12 more
wiley   +1 more source

Bone mineral density and risk of heart failure in older adults: The Cardiovascular Health Study [PDF]

, 2017
Background Despite increasing evidence of a common link between bone and heart health, the relationship between bone mineral density ( BMD ) and heart failure ( HF
Bartz, Traci M, Brown, David L, Carbone, Laura D, Chaves, Paulo H.M., Civitelli, Roberto, Fohtung, Raymond B, Kestenbaum, Bryan R, Kizer, Jorge R, Koh, William J.H., Stein, Phyllis K   +9 more
core   +2 more sources

Validation of a biomarker‐based mortality score for cardiogenic shock patients: Comparison with a clinical risk score

ESC Heart Failure, Volume 12, Issue 3, Page 2157-2165, June 2025.
Abstract Aims Cardiogenic shock (CS) is the deadliest manifestation of acute heart failure, with persistently high mortality rates and a lack of recent therapeutic breakthroughs. Accurate risk prediction is crucial in clinical decision‐making and the design of future clinical trials.
Elina Hynninen, Heli Tolppanen, Mercedes Rivas‐Lasarte, Tuukka Tarvasmäki, Veli‐Pekka Harjola, Benjamin Deniau, Mari Hongisto, Ewa A. Jankowska, Raija Jurkko, Toni Jäntti, Anu Kataja, Alexandre Mebazaa, Tuija Sabell, Alessandro Sionis, Johan Lassus   +14 more
wiley   +1 more source

Inhibition of cysteine peptidase activity in ascitic fluid in pancreatic cancer patients

Folia Histochemica et Cytobiologica, 2010
The work's objective is to answer the question whether there is any possibility of activity inhibition of cysteinepeptidases inhibitors playing an important role in key processes accompanying cancer formation, including pancreas.
Anil Kumar Agrawal, Wojciech Kielan, Abdo Katib, Zygmunt Grzebieniak, Adam Skalski, Tomasz Grzebieniak, £ukasz Duda-Barcik, Anna Janocha, Maciej Siewiñski   +8 more
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