Results 1 to 10 of about 37,835 (197)

Cystatin C is downregulated in prostate cancer and modulates invasion of prostate cancer cells via MAPK/Erk and androgen receptor pathways. [PDF]

PLoS ONE, 2009
Cystatin C is believed to prevent tumor progression by inhibiting the activities of a family of lysosomal cysteine proteases. However, little is known about the precise mechanism of cystatin C function in prostate cancer.
Barbara Wegiel, Thomas Jiborn, Magnus Abrahamson, Leszek Helczynski, Leo Otterbein, Jenny Liao Persson, Jenny Liao Persson, Anders Bjartell   +7 more
doaj   +3 more sources

Glomerular Filtration Rate Estimation Based on Cystatin C Formulas among Neonates [PDF]

Iranian Journal of Neonatology, 2021
Background: Glomerular filtration rate (GFR) is the best indicator to assess renal function; however, it is difficult to perform it, especially in neonates.
Nasrin Khalesi, Farnoosh Seirafianpour, Rozita Hoseini, Hassan Otukesh, Nahid Rahimzadeh, Shahrbanoo Nakhaie, Golnar Gohardehi, Parisa Mohaghegh   +7 more
doaj   +1 more source

Comprehensive Analysis of Interactions between Human Serum Albumin and Human Cystatin C - Two Proteins Present in Body Fluids. [PDF]

ACS Omega
Żyła A, Zhukov I, Taube M, Wojciechowska D, Wolak J, Jurczak P, Czaplewska P, Szymańska A, Martel A, Kozak M.   +9 more
europepmc   +3 more sources

Serum Cystatin C Levels Are Associated With Obesity in Adolescents Aged 14–17 Years

Frontiers in Endocrinology, 2022
BackgroundThe association between serum cystatin C levels and obesity has not been fully explored in adolescents. This study aimed to explore the association between serum cystatin C levels and obesity in adolescents of different sexes.MethodsWe ...
Ying-Xiang Huo, Wei Wei, Yang Liu, Ya-Nan Ma, Jun-Min Tao, Ning-Ning Wang, Xiao-Feng Li, Xin Chen   +7 more
doaj   +1 more source

Megalin dependent urinary cystatin C excretion in ischemic kidney injury in rats. [PDF]

PLoS ONE, 2017
Cystatin C, a marker of kidney injury, is freely filtered in the glomeruli and reabsorbed by the proximal tubules. Megalin and cubilin are endocytic receptors essential for reabsorption of most filtered proteins.
Danny Jensen, Casper Kierulf-Lassen, Marie Louise Vindvad Kristensen, Rikke Nørregaard, Rikke Nørregaard, Kathrin Weyer, Rikke Nielsen, Erik Ilsø Christensen, Henrik Birn   +8 more
doaj   +1 more source

GFR Estimation After Cystatin C Reference Material Change

Kidney International Reports, 2021
Introduction: Glomerular filtration rate (GFR) is routinely estimated with cystatin C. In June 2010, the International Federation of Clinical Chemistry (IFCC) released a certified cystatin C reference material (ERM-DA471/IFCC), and new cystatin C ...
Stefanie W. Benoit, Thelma Kathman, Jay Patel, Melinda Stegman, Cristina Cobb, Jonathan Hoehn, Prasad Devarajan, Edward J. Nehus   +7 more
doaj   +1 more source

Association of serum cystatin C level with coronary atherosclerotic plaque burden: a comprehensive analysis of observational studies and genetic study

BMC Cardiovascular Disorders, 2023
Background and Aims Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements.
Jun Chen, Jiayi Shen, Yuesong Pan, Jing Jing, Yongjun Wang, Tiemin Wei, Lingchun Lyu   +6 more
doaj   +1 more source

Serum Cystatin C as a Potential Marker for Glomerular Filtration Rate in Patients with Cholangiocarcinoma

International Journal of Hematology-Oncology and Stem Cell Research, 2020
Background: Cholangiocarcinoma (CCA) is the second most common primary hepatobiliary cancer. These patients have meager prognosis and short-term survival. Precise assessment of glomerular filtration rate is a fundamental aspect of clinical care in cancer
Mang Ngaih Ciin, Tanakorn Proungvitaya, Temduang Limpaiboon, Ubon Cha’on, Sittiruk Roytrakul, Siriporn Proungvitaya   +5 more
doaj   +1 more source

Mendelian randomization study supports the causal association between serum cystatin C and risk of diabetic nephropathy

Frontiers in Endocrinology, 2022
AimsCystatin C, an inhibitor of cysteine protease, has been used as a biomarker for estimating glomerular filtration rate. However, the causal relation between cystatin C and diabetic nephropathy remains uncertain.MethodsWe assessed the causal effect of ...
Baiyu Feng, Yu Lu, Lin Ye, Lijun Yin, Yingjun Zhou, Anqun Chen   +5 more
doaj   +1 more source

Increased Cystatin C in Astrocytes of Transgenic Mice Expressing the K670N-M671L Mutation of the Amyloid Precursor Protein and Deposition in Brain Amyloid Plaques

Neurobiology of Disease, 2001
Cystatin C is an essential secretory cofactor for neurogenesis with potent protease inhibitor activities. Polymorphisms of cystatin C are genetically associated with Alzheimer's disease (AD), and the L68Q mutation causes hereditary cerebral hemorrhage ...
Tiana Steinhoff, Eva Moritz, M.Axel Wollmer, M.Hasan Mohajeri, Stefan Kins, Roger M. Nitsch   +5 more
doaj   +1 more source