Results 91 to 100 of about 37,835 (197)

Salivary Proteomic Signatures in Pregnant Women With Excessive Gingival Bleeding

Oral Diseases, EarlyView.
ABSTRACT Objective This observational, cross‐sectional, and analytical study aimed to explore the pathophysiological mechanisms of gingivitis in pregnancy by analyzing the salivary proteomic profile according to gingival bleeding status. Materials and Methods Pregnant women at the 27th week of gestation or beyond were categorized into two groups: those
Gerson Aparecido Foratori‐Junior, Clovis Bergamin Griso, Amanda Borges Pirondi, Laura Teodoro de Marchi, Talita Mendes Oliveira Ventura, Larissa Tercilia Grizzo, Roosevelt da Silva Bastos, Alejandra Chaparro, Nagihan Bostanci, Marília Afonso Rabelo Buzalaf   +9 more
wiley   +1 more source

Serum cytokines in periodontal diseases

Periodontology 2000, EarlyView.
Abstract Periodontal disease, including gingivitis and periodontitis, is a chronic inflammatory condition that leads to the destruction of the supporting structures of teeth. The disease is characterized by a complex immune response, where cytokines play a central role in regulating both inflammation and tissue breakdown.
Paras Ahmad, Jørgen Slots, Walter L. Siqueira   +2 more
wiley   +1 more source

Assessing the exercise‐related kinetics of circulating cell‐free DNA, circulating tumour DNA, DNase I activity and cytokines in patients with solid tumours: A pilot study

Experimental Physiology, EarlyView.
Abstract Circulating cell‐free DNA (cfDNA), circulating tumour DNA (ctDNA) and inflammatory cytokines have prognostic and predictive value in oncology. However, the effects of acute exercise on cfDNA levels are unknown. Here, we explore the kinetics of cfDNA, ctDNA and cytokines upon an incremental exercise test in a pilot cohort of cancer patients ...
Elmo W. I. Neuberger, Alexandra Brahmer, Tobias Ehlert, Suzan Botzenhardt, Alfonso De Falco, Birgit Enders, Patricia S. Hähnel, Achim Heintz, Carl C. Schimanski, Thomas Kindler, Perikles Simon   +10 more
wiley   +1 more source

Author Correction: Beta Trace Protein does not outperform Creatinine and Cystatin C in estimating Glomerular Filtration Rate in Older Adults [PDF]

, 2019
Natalie Ebert, Camilla Koep, Kristin Schwarz, Peter Martus, Nina Mielke, Jan Bartel, Martin K. Kuhlmann, Jens Gaedeke, M. Toelle, Markus van der Giet, Mirjam Schuchardt, Elke Schäeffner   +11 more
openalex   +1 more source

Variant Classification Using Proteomics‐Informed Large Language Models Increases Power of Rare Variant Association Studies and Enhances Target Discovery

Genetic Epidemiology, Volume 49, Issue 8, December 2025.
ABSTRACT Rare variant association analysis, which assesses the aggregate effect of rare damaging variants within a gene, is a powerful strategy for advancing knowledge of human biology. Numerous models have been proposed to identify damaging coding variants, with the most recent ones employing deep learning and large language models (LLMs) to predict ...
Christopher E. Gillies, Joelle Mbatchou, Lukas Habegger, Michael D. Kessler, Suying Bao, Suganthi Balasubramanian, Olivier Delaneau, Jack A. Kosmicki, Cristen J. Willer, Hyun Min Kang, Aris Baras, Jeffrey G. Reid, Jonathan Marchini, Gonçalo R. Abecasis, Maya Ghoussaini   +14 more
wiley   +1 more source

Serum Creatinine/Cystatin C Ratio as a Predictor of In-hospital Mortality in Patients Hospitalized with Acute Exacerbation of Chronic Obstructive Pulmonary Disease [PDF]

, 2022
Zhixiang Chen, Lei Zha, Xiao Ma, Jing Xu, Dandan Huang, Wenlong Wu, Long Chen, Feng Yang, Wei-Ling Liao, Wenhua Wang   +9 more
openalex   +1 more source

Transcriptional Regulation of Microglial Metabolic and Activation States by P2RY12

Glia, Volume 73, Issue 12, Page 2464-2482, December 2025.
Main Points Transcriptionally, P2RY12‐deficient microglia show heightened metabolic activity, iron handling and oxidative stress at baseline. Upon LPS challenge, impaired glutathione antioxidant responses suggest increased vulnerability to ferroptosis. ABSTRACT Microglia are the resident immune cells of the CNS.
Aida Oryza Lopez‐Ortiz, Madison Doceti, JaQuinta Thomas, Abigayle Duffy, Morgan Coburn, Akhabue K. Okojie, Audrey Lee, Elizabeth Aidita Sou, Alban Gaultier, Ukpong B. Eyo   +9 more
wiley   +1 more source

Autophagy dysfunction and regulatory cystatin C in macrophage death of atherosclerosis [PDF]

, 2016
Wei Li, Nargis Sultana, Nabeel Siraj, Liam J. Ward, Monika Pawlik, Efrat Levy, Stefan Jovinge, Eva Bengtsson, Xi Yuan   +8 more
openalex   +1 more source

A Creatinine–CAR Composite Index (CCAR) Optimized by Machine Learning for Prognosis in Cancer Cachexia

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Cancer cachexia is a multifactorial syndrome associated with poor prognosis and impaired quality of life in cancer patients. However, survival prediction in cancer cachexia remains difficult due to the lack of reliable biomarkers.
Heyang Zhang, Chong Li, Qiuyi Chen, Jinyu Shi, Wenjing Wang, Guotian Ruan, Chenan Liu, Shutian Zhang, Shengtao Zhu, Peng Li, Hanping Shi   +10 more
wiley   +1 more source

Growth/Differentiation Factor 15 Promotes a Pro‐Regenerative Response in Chondrocytes Upon Cartilage Injury

MedComm, Volume 6, Issue 12, December 2025.
After cartilage injury, oxidative stress results in a posttraumatic cell fate decision: Intracellular ROS accumulation initiates a p53‐dependent stress response in chondrocytes, including the transcription of signature genes, such as CDKN1A and GDF15.
Sara Sofi Marques, Alexandra Liebaug, Svenja Maurer, Dietrich Rothenbacher, Rolf E. Brenner, Jana Riegger   +5 more
wiley   +1 more source