Results 131 to 140 of about 60,453 (247)

Phenotyping of Fontan‐Associated Renal Physiology and Disease

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
In patients with a Fontan circulation, both kidney function and glomerular injury progressively decline with age, with a stronger decline than in healthy individuals. Additionally, intrarenal haemodynamics in patients with a Fontan circulation demonstrate decreased venous and arterial compliance, evident through elevated venous impedance and renal ...
Gaston van Hassel, Jozine M. ter Maaten, Iris E. Beldhuis, Eryn T. Liem, Bastiaan Zwart, Stephan J. L. Bakker, Rolf M. F. Berger, Joost P. van Melle   +7 more
wiley   +1 more source

Human cystatin C in fibrotic diseases

Clinica Chimica Acta
Human cystatin C (hCC), which has a pervasive distribution within body fluids and is ubiquitously expressed by numerous cells and tissues, is a highly potent extracellular inhibitor of cysteine proteases. Besides measurement of serum creatinine, which is the most widely used technique for appraising glomerular filtration rate (GFR), hCC has emerged as ...
Gilles Lalmanach, Baptiste Rigoux, Alexis David, Mounia Tahri-Joutey, Fabien Lecaille, Sylvain Marchand-Adam, Ahlame Saidi   +6 more
openaire   +2 more sources

An IQ Consortium Perspective on the FDA Guidance for Assessment of Pharmacokinetics in Participants With Impaired Renal Function

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 838-845, April 2026.
The FDA published guidance on assessing pharmacokinetics (PK) in participants with impaired renal function in 2024. The IQ CPLG Organ Impairment Working Group summarized the industry’s perspective on this guidance by highlighting a few key updates in the 2024 guidance, including: (1) the recommendation of using estimated glomerular filtration rate ...
Yan Jin, Ashish Sharma, Mariam A. Ahmed, Sravanthi Cheeti, Ying Ou, Damayanthi Devineni, Yizhe Chen, Jitendra S. Kanodia, Yasmeen Abouelhassan, Nadia Noormohamed, Jin Zhou, Patrick Marroum, Vaishali Sahasrabudhe, Islam R. Younis   +13 more
wiley   +1 more source

A Scoping Review of Pharmacist‐Based Interprofessional Interventions for Management of Cardiovascular‐Kidney‐Metabolic Conditions

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 4, April 2026.
ABSTRACT Background Co‐existence of multiple cardiovascular‐kidney‐metabolic (CKM) conditions, such as chronic kidney disease (CKD), type 2 diabetes (T2D), and cardiovascular disease, is common. The interconnected nature of CKM conditions emphasizes the need for an interprofessional approach to patient care.
Wendy L. St. Peter, Joshua J. Neumiller, Radica Alicic, Sheryl L. Chow, Hadley Dowell, O. Kenrik Duru, Patrick Gee, Roy O. Mathew, Susanne B. Nicholas, Janani Rangaswami, Glenda V. Roberts, Muthiah Vaduganathan, Katherine R. Tuttle   +12 more
wiley   +1 more source

Effects of Phenolic‐Rich Extra Virgin Olive Oil and Prebiotics on Sarcopenia in Older Adults: FOOP‐Sarc Project

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Management of sarcopenia by nutritional and lifestyle interventions is a challenge. The aim is to assess the effectiveness of a phenolic‐rich extra virgin olive oil (EVOO), alone or combined with a prebiotic (PREB) (fructooligosaccharides and inulin), to improve skeletal muscle mass and function in home‐dwelling older adults (60–80 ...
Maria Besora‐Moreno, Claudia Jiménez‐ten Hoevel, Judit Queral, Glòria Bernal, Laura Pérez‐Merino, José Puzo, Laura Conangla‐Ferrin, Leann Constance Sleebos, Wout van Helden, Elisabet Llauradó, Rosa M. Valls, Rosa Solà, Anna Pedret   +12 more
wiley   +1 more source

Diabetic kidney disease, biomarkers, and finerenone

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2582-2593, April 2026.
Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
wiley   +1 more source

Ketone Body Supplementation Exerts Renoprotective Effects Against Adenine‐Induced Kidney Injury via OXCT1‐Mediated Ketolysis in Mice

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
1,3‐Butanediol is a ketone body precursor that is directly converted into the ketone bodies, β‐hydroxybutyrate (BHB), in the liver. When renal ketolysis, regulated by 3‐oxoacid CoA‐transferase 1 (OXCT1), is preserved, BHB supplementation exerts renoprotective effects.
Shoji Omachi, Sho Sugahara, Junya Horiguchi, Mako Yasuda‐Yamahara, Shogo Kuwagata, Kosuke Yamahara, Yuki Tanaka‐Sasaki, Shogo Ida, Tetsuro Kusaba, Benjamin D. Humphreys, Kenji Kufukihara, Jin Nakahara, Masami Chin‐Kanasaki, Shinji Kume   +13 more
wiley   +1 more source

The NKF Has Spoken: Now, What's a Clinician to Do?

Journal of the American Geriatrics Society, EarlyView.
Barbara J. Zarowitz, Cindy Van, Todd P. Semla   +2 more
wiley   +1 more source

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, Volume 78, Issue 3, Page 548-557, March 2026.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, for the Lupus Nephritis Classification Steering Committee   +11 more
wiley   +1 more source

Diagnosis of some diseases through biomarkers [PDF]

, 2019
Muchos gatos, como los perros, sufren de diferentes enfermedades. que en ese momento no permiten mostrar síntomas o signos que permiten identificar que la mascota sufre una enfermedad grave, ya que las características de los gatos son diferentes a las de
Gutiérrez Rodríguez, Andrea
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