Results 131 to 140 of about 19,945,001 (395)
Clinical Pharmacology in Drug Development, EarlyView.Abstract RBN‐3143 is an inhibitor of PARP14 in development for inflammatory diseases. Multiple assessments were conducted to evaluate the clinical pharmacology properties of RBN‐3134. A randomized, double‐blind, placebo‐controlled study assigned healthy volunteers (HVs) to single ascending doses (SADs) (25‐1000 mg) or multiple ascending doses (MADs ...
Thomas M. Polasek +9 more
wiley +1 more source
Cluster-tilted algebras as trivial extensions [PDF]
arXiv, 2006 Given a finite dimensional algebra $C$ (over an algebraically closed field) of global dimension at most two, we define its relation-extension algebra to be the trivial extension $C\ltimes \Ext_C^2(DC,C)$ of $C$ by the $C$-$C$-bimodule $\Ext_C^2(DC,C)$. We give a construction for the quiver of the relation-extension algebra in case the quiver of $C$ has
arxiv
Microalbuminuria, but not cystatin C, is associated with carotid atherosclerosis in middle-aged adults [PDF]
, 2017 Background. Cystatin C, a marker of renal function, has been shown to be an independent predictor of cardiovascular disease (CVD) in older adults, but few data are available in middle-aged adults.
Bovet, Pascal +6 more
core
Successful Vancomycin Dose Adjustment in a Sepsis patient with Bacterial Meningitis Using Cystatin C [PDF]
, 2020 Cystatin C-guided vancomycin (VCM) dosing is useful in critically ill patients. Its usefulness in septic patients with bacterial meningitis remains unknown, as there are no published reports. In this study, we sought to clarify its benefit.
Asada, Mizuho +10 more
core +1 more source
Cystatin C for Therapeutic Drug Monitoring
Clinical Chemistry, 2015 A 78-year-old man with prostate cancer needed intravenous treatment with amikacin for a suspected gram-negative bacillary respiratory infection. He had a body surface area of 1.97 m2, weight of 78 kg, and body mass index of 29 kg/m2. Laboratory test results are shown in Table 1. Because the initial renal function was judged to be normal and the patient
Francisco Javier Cepeda-Piorno +1 more
openaire +3 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Accurately assessing glomerular filtration rate (GFR) from plasma creatinine concentrations is challenging in patients with unstable renal function. This study aimed to refine the understanding of creatinine kinetics for more reliable assessments of GFR and net creatinine tubular secretion (nCTS) via OCT2/MATE in humans.
Zhendong Chen +5 more
wiley +1 more source
Perfect graphs of fixed density: counting and homogenous sets [PDF]
arXiv, 2011 For c in [0,1] let P_n(c) denote the set of n-vertex perfect graphs with density c and C_n(c) the set of n-vertex graphs without induced C_5 and with density c. We show that log|P_n(c)|/binom{n}{2}=log|C_n(c)|/binom{n}{2}=h(c)+o(1) with h(c)=1/2 if 1/4
arxiv
Urinary Cystatin C, Glucose, Urea, and Electrolytes in Dogs at Various Stages of Chronic Kidney Disease. [PDF]
J Vet Intern MedABSTRACT Background There is limited knowledge of urine analytes in different stages of chronic kidney disease (CKD) in dogs. Objectives To study markers in urine and fractional excretion (FE) of markers in dogs of different stages of CKD and a healthy control group (C). Animals Fifty dogs in various stages of CKD and a control group of 30 healthy dogs.
Selin AK +4 more
europepmc +2 more sources
ESC Heart Failure, Volume 12, Issue 2, Page 1194-1202, April 2025.Abstract Aims Cardiac decompensation in cardiorenal syndrome (CRS) results in systemic congestion usually treated with diuretics. When despite high doses of diuretics, response is poor, ultrafiltration (UF) appears to be a useful and safe technique.
Borja Guerrero Cervera +12 more
wiley +1 more source
Journal of the Saudi Heart Association, 2016 Aims: Cystatin C is an endogenous marker of renal function. It is a well established better marker of glomerular filtration rate than serum creatinine. There is also evidence that cystatin C is associated with atherosclerotic disease.
Leila Abid +4 more
doaj +1 more source