Results 31 to 40 of about 19,945,001 (395)

Association of Intraindividual Difference in Estimated Glomerular Filtration Rate by Creatinine vs Cystatin C and End-stage Kidney Disease and Mortality

JAMA Network Open, 2022
Key Points Question Are differences between estimated glomerular filtration rate by cystatin C (eGFRcys) vs creatinine (eGFRcr) associated with the risk of end-stage kidney disease (ESKD) and mortality among individuals with chronic kidney disease (CKD)?
MD DebbieC.Chen, Mdmph MichaelG.Shlipak, PhD RebeccaScherzer, MDScM ScottR.Bauer, MD O.AlisonPotok, Mdms DenaE.Rifkin, Mdmas JoachimH.Ix, Mdmph AnthonyN.Muiru, MDMSc Chi-yuanHsu, Mdmhs MichelleM.Estrella, ShlipakRifkinIxHsuEstrella Chen, ShlipakScherzerBauerPotokRifkin Chen, HsuEstrella Muiru, Muiru   +13 more
semanticscholar   +1 more source

Serum creatinine and cystatin C‐based diagnostic indices for sarcopenia in advanced non‐small cell lung cancer

Journal of Cachexia, Sarcopenia and Muscle, 2022
Sarcopenia is an important prognostic factor of lung cancer. The serum creatinine/cystatin C ratio (CCR) and the sarcopenia index (SI, serum creatinine × cystatin C‐based glomerular filtration rate) are novel screening tools for sarcopenia; however, the ...
Tianjiao Tang, Lingling Xie, Song Hu, L. Tan, Xiaozhen Lei, Xiaozhen Luo, Ling Yang, Ming Yang   +7 more
semanticscholar   +1 more source

Cystatin C in Alzheimer's disease [PDF]

Frontiers in Molecular Neuroscience, 2012
Changes in expression and secretion levels of cystatin C (CysC) in the brain in various neurological disorders and in animal models of neurodegeneration underscore a role for CysC in these conditions. A polymorphism in the CysC gene (CST3) is linked to increased risk for Alzheimer's disease (AD).
Gurjinder Kaur, Efrat Levy
openaire   +4 more sources

The complexity of kidney disease and diagnosing it – cystatin C, selective glomerular hypofiltration syndromes and proteome regulation

Journal of Internal Medicine, 2022
Estimation of kidney function is often part of daily clinical practice, mostly done by using the endogenous glomerular filtration rate (GFR)‐markers creatinine or cystatin C.
L. Malmgren, C. Öberg, Emil den Bakker, Felicia Leion, J. Siódmiak, A. Åkesson, V. Lindström, Erik Herou, A. Dardashti, Liana Xhakollari, Gabriel Grubb, H. Strevens, M. Abrahamson, J. Helmersson-Karlqvist, M. Magnusson, J. Björk, U. Nyman, J. Ärnlöv, P. Ridefelt, T. Åkerfeldt, M. Hansson, A. Sjöström, J. Mårtensson, Y. Itoh, D. Grubb, O. Tenstad, L. Hansson, I. Olafsson, Araceli Jarquin Campos, M. Risch, L. Risch, A. Larsson, G. Nordin, H. Pottel, A. Christensson, H. Bjursten, A. Bökenkamp, A. Grubb   +37 more
semanticscholar   +1 more source

Association of Cystatin C Kidney Function Measures With Long-term Deficit-Accumulation Frailty Trajectories and Physical Function Decline

JAMA Network Open, 2022
Key Points Question Are kidney function measures, including cystatin C level, cystatin C estimated glomerular filtration rate (eGFRcys), and the difference between eGFRs (eGFRdiff) using cystatin C and creatinine, associated with long-term deficit ...
Chenglong Li, Yanjun Ma, Chao Yang, R. Hua, Wuxiang Xie, Luxia Zhang   +5 more
semanticscholar   +1 more source

Cystatin C uptake in the eye [PDF]

Graefe's Archive for Clinical and Experimental Ophthalmology, 2004
As a secreted protein, cystatin C is assumed to play its role in the extracellular compartment, where it can inhibit virtually all cysteine proteases of families C1 (cathepsin B, L, S) and C13 (mammalian legumain-related proteases). Since many of its potential target enzymes in the eye reside in intracellular compartments, we sought evidence for a ...
Berndt Ehinger, Magnus Abrahamson, Johan Wassélius, Kjell Johansson, Katarina Håkansson   +4 more
openaire   +3 more sources

Association of serum cystatin C level with coronary atherosclerotic plaque burden: a comprehensive analysis of observational studies and genetic study

BMC Cardiovascular Disorders, 2023
Background and Aims Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements.
Jun Chen, Jiayi Shen, Yuesong Pan, Jing Jing, Yongjun Wang, Tiemin Wei, Lingchun Lyu   +6 more
doaj   +1 more source

Cystatin C and Uncontrolled Hypertension

The Anatolian Journal of Cardiology, 2020
Increased serum level of cystatin C, a sensitive biomarker for renal function, seems to predict adverse cardiovascular events. We investigated the predictive value of serum cystatin C for controlling hypertension in an observational study.We screened 1037 adults residing in both rural and urban communities.
Omaygenç, Mehmet Onur, Özcan, Özgür Ulaş, Çakal, Beytullah, Karaca, Oğuz   +3 more
openaire   +6 more sources

Mendelian randomization study supports the causal association between serum cystatin C and risk of diabetic nephropathy

Frontiers in Endocrinology, 2022
AimsCystatin C, an inhibitor of cysteine protease, has been used as a biomarker for estimating glomerular filtration rate. However, the causal relation between cystatin C and diabetic nephropathy remains uncertain.MethodsWe assessed the causal effect of ...
Baiyu Feng, Yu Lu, Lin Ye, Lijun Yin, Yingjun Zhou, Anqun Chen   +5 more
doaj   +1 more source

Creatinine–cystatin C ratio and mortality in cancer patients: a retrospective cohort study

Journal of Cachexia, Sarcopenia and Muscle, 2021
Muscle wasting is prevalent in cancer patients, and early recognition of this phenomenon is important for risk stratification. Recent studies have suggested that the creatinine–cystatin C ratio may correlate with muscle mass in several patient ...
C. Jung, Hyungwoo Kim, S. Han, T. Yoo, Shin-Wook Kang, J. Park   +5 more
semanticscholar   +1 more source