Results 41 to 50 of about 37,835 (197)

Deep phenotyping of heart failure with preserved ejection fraction through multi‐omics integration

European Journal of Heart Failure, EarlyView.
Deep phenotyping of of heart failure with preserved ejection fraction (HFpEF) through multi‐omics integration. AI, artificial intelligence. Aims Heart failure with preserved ejection fraction (HFpEF) has become the predominant form of heart failure and a leading cause of global cardiovascular morbidity and mortality.
Jakob Versnjak, Titus Kuehne, Pauline Fahjen, Nina Jovanovic, Ulrike Löber, Gabriele G. Schiattarella, Nicola Wilck, Holger Gerhardt, Dominik N. Müller, Frank Edelmann, Philipp Mertins, Roland Eils, Michael Gotthardt, Sofia K. Forslund, Benjamin Wild, Marcus Kelm   +15 more
wiley   +1 more source

Serum cystatin C levels in Healthy Nigerian neonates: Is there a need for normative values in Nigerian babies?

Saudi Journal of Kidney Diseases and Transplantation, 2017
Cystatin C is an endogenous marker of renal function. Normal reference values have been documented in neonates outside Africa, but no study has been documented in African neonates. With reports that race may affect serum cystatin C values, this study was
Akpoembele D Madise-Wobo, Olusegun H Gbelee, Adaobi Solarin, Barakat A Animasahun, Olisamedua F Njokanma   +4 more
doaj   +1 more source

Urinary markers in heart failure – types, timing and thresholds. European Journal of Heart Failure expert consensus document

European Journal of Heart Failure, EarlyView.
Pathophysiologic mechanisms of heart failure (HF) (i.e. renin–angiotensin–aldosterone system [RAAS], congestion, and inflammation), together with patient‐related factors such as diabetes, hypertension, and chronic kidney disease (CKD), contribute to kidney function decline and glomerular or tubular injury.
Masatake Kobayashi, Biykem Bozkurt, Peder Langeland Myhre, Juan Carlos Lopez Azor, Mateusz Guzik, Gracjan Iwanek, Guillaume Baudry, Marta Cobo‐Marcos, Òscar Miró, Jeroen Dauw, Piotr Ponikowski, Wilfried Mullens, Alberto Palazzuoli, Marco Metra, Jan Biegus   +14 more
wiley   +1 more source

Exploring the role of apolipoprotein ε4 in progressive myoclonic epilepsy type 1

Epileptic Disorders, EarlyView.
Abstract Objective Progressive myoclonic epilepsy type 1 (EPM1) is a neurodegenerative disease caused by biallelic variants in the cystatin B (CSTB) gene. Despite a progressive course, phenotype severity varies among patients, even within families. We studied the potential role of APOE ε4 in modifying phenotypic diversity in EPM1, given its established
Janina Gunnar, Yawu Liu, Henri Eronen, Tarja Joensuu, Marja Äikiä, Jelena Hyppönen, Katri Silvennoinen, Esa Mervaala, Juhana Hakumäki, Anna‐Elina Lehesjoki, Reetta Kälviäinen   +10 more
wiley   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Does Cystatin C have a role as metabolic surrogate in peritoneal dialysis beyond its association with residual renal function?

Brazilian Journal of Nephrology, 2019
Introduction: It has been suggested that cystatin C levels are modified by obesity and inflammation. Furthermore, cystatin C has been associated with cardiovascular events and mortality outcomes.
Carla Leal Moreira, Liliana Cunha, Sofia Correia, Filipa Silva, Ana Castro, Joana Tavares, Maria João Carvalho, José Carlos Oliveira, Olívia Santos, António Cabrita, Anabela Rodrigues   +10 more
doaj   +2 more sources

Bifidobacterium longum subsp. longum CCFM1375 Mitigates Chronic Kidney Disease Progression via Gut Microbiota Modulation and Gut Barrier Restoration

Food Frontiers, EarlyView.
(1) Bifidobacterium longum subsp. longum CCFM1375 restored gut barrier integrity by upregulating ZO‐1/ZO‐2 and suppressing IL‐6/TNF‐α, thereby reducing serum LPS and improving creatinine/BUN levels. (2) Reshaped gut microbiota: enriched beneficial species (Faecalibaculum rodentium, Asaccharobacter celatus, Adlercreutzia equolifaciens) while suppressing
Hongchao Wang, Xinchen Lv, Yue Zhang, Jinlin Zhu, Jia Hua, Bin Liu, Jianxin Zhao, Hao Zhang, Wei Chen, Wenwei Lu, Zhijian Zhang, Liang Wang   +11 more
wiley   +1 more source

Cadmium exposure, epigenetic modifications, and serum cystatin C: insights into mediated pathways and mortality risks in U.S. adults

Clinical Epigenetics
Background Cadmium exposure has been linked to elevated cystatin C levels, disruptions in epigenetic patterns, and increased mortality risk. However, the role of epigenetic modifications in the relationship between cadmium and cystatin C remains poorly ...
Yu-Wei Fang, Ching-Way Chen, Ta-Chen Su, Chien-Yu Lin   +3 more
doaj   +1 more source

Effects of immune checkpoint inhibitors on the pulmonary circulation in lung cancer patients

International Journal of Cancer, EarlyView.
What's New? Immune checkpoint inhibitors (ICIs) are effective against various cancers, but as more patients receive these therapies, more immune‐related adverse events (irAEs) emerge. Recent studies have suggested that ICIs are associated with an increase in pulmonary artery diameter and the ratio between pulmonary artery diameter and aortic diameter ...
Yao Xu, Qiuhong Zhang, Jie Gao, Shiyuan Yao, Chan Tian, Tuo He, Ming Zhang, Hu Shan, Jie Shi, Bo Yuan, Lei Wang, Xia Yang   +11 more
wiley   +1 more source

Cystatin C: A prognostic marker after myocardial infarction in patients without chronic kidney disease

Journal of the Saudi Heart Association, 2016
Aims: Cystatin C is an endogenous marker of renal function. It is a well established better marker of glomerular filtration rate than serum creatinine. There is also evidence that cystatin C is associated with atherosclerotic disease.
Leila Abid, Salma Charfeddine, Samir Kammoun, Mouna Turki, Fatma Ayedi   +4 more
doaj   +1 more source