Results 71 to 80 of about 37,835 (197)

The Roles of EDA2R in Ageing and Disease

open access: yesAging Cell, EarlyView.
Elevated expression of the ectodysplasin A2 receptor (EDA2R) has been linked to ageing and disease. We appraise the roles of EDA2R in these processes, exploring mechanisms of action, biomarker potential and therapeutic relevance of EDA2R in multiple contexts. ABSTRACT Ageing is a complex biological process driven, in part, by inflammaging.
Gemma Farrington   +9 more
wiley   +1 more source

The regulatory role of cystatin C in autophagy and neurodegeneration

open access: yesВавиловский журнал генетики и селекции, 2019
Autophagy is a dynamic cellular process involved in the turnover of proteins, protein complexes, and organelles through lysosomal degradation. It is particularly important in neurons, which do not have a proliferative option for cellular repair ...
T. A. Korolenko   +9 more
doaj   +1 more source

Elevated serum cystatin C level is an independent predictor of contrast-induced nephropathy and adverse outcomes in patients with peripheral artery disease undergoing endovascular therapy [PDF]

open access: bronze, 2015
Gwang-Sil Kim   +7 more
openalex   +1 more source

Tubulointerstitial nephritis and uveitis syndrome in children: What to keep an eye on

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose The purpose of this study was to determine the disease course in patients with tubulointerstitial nephritis and uveitis (TINU) syndrome, focusing on long‐term outcome and the incidence of complications such as chronic kidney disease (CKD).
Jytte Hendrikse   +4 more
wiley   +1 more source

Dupilumab Dampens Mucosal Type 2 Response During Acetylsalicylic Acid Challenge in N‐ERD Patients

open access: yesClinical &Experimental Allergy, EarlyView.
Dupilumab therapy reduced elevated type 2 cytokine responses post‐ASA provocation in N‐ERD patients, independent of ASA tolerance, and revealed novel mechanistic insights by modulating acute type 2 immunity. Transcriptomic analysis showed concurrent downregulation of lipid and peroxisome pathways during ASA challenge in N‐ERD patients after 24 weeks of
Julia Eckl‐Dorna   +10 more
wiley   +1 more source

Corticosteroids significantly increase cystatin C levels in the plasma by promoting cystatin C production in rats

open access: yesRenal Failure, 2019
Background: Several studies have shown that non-renal factors such as corticosteroids may increase plasma cystatin C levels without affecting kidney function. However, the mechanisms underlying this are unclear.
Xiao-Ran Zhu   +4 more
doaj   +1 more source

Cystatin C and asymptomatic coronary artery disease in patients with metabolic syndrome and normal glomerular filtration rate

open access: yesCardiovascular Diabetology, 2012
Background All of the components of Metabolic syndrome (MetS) have been regarded as risk factors for coronary artery disease (CAD). Early detection of CAD in asymptomatic patients with MetS remains a challenge.
Qing Xie   +5 more
doaj   +1 more source

Plasma creatine, estimated intramuscular creatine, transcellular gradient and the risk of mortality: Results from the PREVEND study

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
Plasma creatine and intramuscular creatine concentrations were assessed using nuclear magnetic resonance and bio‐electrical impedance analysis in a general population‐based cohort (n = 5127). Cox‐regression analyses were performed to investigate associations with mortality.
Caecilia S. E. Doorenbos   +7 more
wiley   +1 more source

Investigation of serum cystatin C levels and their diagnostic value in combination with inflammatory ratios in patients with bipolar disorder

open access: yesFrontiers in Psychiatry
BackgroundIt is thought that inflammation significantly contributes to the development of bipolar disorder (BD), and recent findings indicate a connection between cystatin C and immune-related inflammation. In this study, we investigated serum cystatin C
Chenjiao Zhang   +7 more
doaj   +1 more source

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