Results 11 to 20 of about 25,803 (305)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background We have shown previously that low‐density lipoprotein (LDL) can be oxidized in the lysosomes of macrophages, that this oxidation can be inhibited by cysteamine, an antioxidant that accumulates in lysosomes, and that this drug decreases ...
Feroz Ahmad +8 more
doaj +2 more sources
Cysteamine exerts in vitro antiviral activity against the SARS-CoV-2 Delta and Omicron variants
Cell Death Discovery, 2022 The novel SARS-CoV-2 variants of concern (VOC) represent a considerable global alarm because their mutations are known to affect transmissibility and cause immune escape.
Tonino Alonzi +9 more
doaj +2 more sources
Effects of Coated Cysteamine on Oxidative Stress and Inflammation in Weaned Pigs
Animals, 2021 This study aimed to explore the effects of dietary coated cysteamine on oxidative stress and inflammation in diquat-induced weaning pigs. Twenty-four pigs were randomly assigned to three dietary groups with eight replicates: the control (fed base diet ...
Shanshan Wang +8 more
doaj +2 more sources
Cells, 2021 The ongoing pandemic of coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), needs better treatment options both at antiviral and anti-inflammatory levels.
Tonino Alonzi +13 more
doaj +2 more sources
Challenges for cysteamine stabilization, quantification, and biological effects improvement
Journal of Pharmaceutical Analysis, 2020 The aminothiol cysteamine, derived from coenzyme A degradation in mammalian cells, presents several biological applications. However, the bitter taste and sickening odor, chemical instability, hygroscopicity, and poor pharmacokinetic profile of ...
Carla Atallah +2 more
doaj +2 more sources
Cysteamine Inhibits Glycine Utilisation and Disrupts Virulence in Pseudomonas aeruginosa
Frontiers in Cellular and Infection Microbiology, 2021 Pseudomonas aeruginosa is a major opportunistic human pathogen which employs a myriad of virulence factors. In people with cystic fibrosis (CF) P. aeruginosa frequently colonises the lungs and becomes a chronic infection that evolves to become less ...
Douglas J. Fraser-Pitt +12 more
doaj +2 more sources
Spectroscopic Investigation of Cysteamine Dioxygenase
Biochemistry, 2020 Thiol dioxygenases are mononuclear non-heme FeII-dependent metalloenzymes that initiate the oxidative catabolism of thiol-containing substrates to their respective sulfinates. Cysteine dioxygenase (CDO), the best characterized mammalian thiol dioxygenase, contains a three-histidine (3-His) coordination environment rather than the 2-His-1-carboxylate ...
Rebeca L. Fernandez +4 more
openaire +5 more sources
BMC Veterinary Research, 2019 Background Cysteamine was coated to cover its odor and maintain the stability. However, coated cysteamine (CC) has not been clearly evaluated for its effects on the gastrointestinal mucosa status. We hypothesize that the appropriate CC supplementation in
Hongnan Liu +6 more
doaj +2 more sources
Is cysteamine use effective in the treatment of melasma? A systematic review and meta‐analysis
Dermatologic Therapy, 2022 Melasma is a recurrent hypermelanosis disorder characterized by the appearance of brownish and symmetrical spots on the skin. It affects the quality of life and is resistant to available treatment approaches.
Agenor Gomes dos Santos-Neto +4 more
semanticscholar +1 more source
Human Molecular Genetics, 2022 Cysteamine is currently the only therapy for nephropathic cystinosis. It significantly improves life expectancy and delays progression to end-stage kidney disease; however, it cannot prevent it.
Ester De Leo +14 more
semanticscholar +1 more source