Results 31 to 40 of about 10,629 (179)

Oral cysteamine as an adjunct treatment in cystic fibrosis pulmonary exacerbations: An exploratory randomized clinical trial [PDF]

, 2020
Background Emerging data suggests a possible role for cysteamine as an adjunct treatment for pulmonary exacerbations of cystic fibrosis (CF) that continue to be a major clinical challenge.
Fraser-Pitt, Douglas J., Murray, L, Dougherty, Ryan, Peckham, Daniel, Devereux, G, Wrolstad, D, Doe, S, MacGregor, G, Bourke, Stephen J., O'Neil, Deborah A., Lascano, Jorge, O'Neil, DA, Lucidi, Vincenzina, Robertson, Jennifer, Wrolstad, Danielle, Daines, Cori L., Kopp, Benjamin T., Lovie, E, Kopp, BT, Dougherty, R, Franco, Rose, Bourke, SJ, Innes, A, Lascano, J, Franco, R, Lovie, Emma, Lucidi, V, Layish, D, Robertson, J, Fraser-Pitt, DJ, Daines, CL, Devereux, Graham, Innes, Alastair, Layish, Daniel, Peckham, D, Murray, Lorna, Doe, Simon, MacGregor, Gordon   +37 more
core   +3 more sources

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Increased human dermal microvascular endothelial cell survival induced by cysteamine

, 2013
Contains fulltext : 125972.pdf (Publisher’s version ) (Open Access)BACKGROUND: Cystinosis is an autosomal recessive disease caused by intralysosomal cystine accumulation, treated with cysteamine.
I. Bongaers, Bongaers, I., R. van Eijsden, M. Dewerchin, Besouw, M., Kluijtmans, L.A., van Eijsden, R., Kluijtmans, L., L. Kluijtmans, van den Heuvel, L., Levtchenko, E., Dewerchin, M., Eijsden, R. van, E. Levtchenko, M. Besouw, L. den van Heuvel, Heuvel, L.P. van den, Levtchenko, E.N.   +17 more
core   +1 more source

Lead‐free halide perovskites for efficient light‐emitting devices

FlexMat, EarlyView.
Overview of Lead‐free metal halide perovskites with different categories and optoelectronic application directions, including solid‐state lighting, light‐emitting diodes, piezoluminescence, flexible electronics, scintillators and CPL emitters. Abstract Lead halide perovskites exhibit promising optoelectronic properties for optoelectronic applications ...
Yueqi Shen, Kefan Meng, Yiqi Zhao, Chaoran Zhou, Jiaye Shu, Di Zhang, Chengqian Cao, Wanxin Chen, Yefeng Zhou, Weihua Ning   +9 more
wiley   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Synthesis of diacylated γ-glutamyl-cysteamine prodrugs, and in vitro evaluation of their cytotoxicity and intracellular delivery of cysteamine

, 2015
To overcome the major disadvantages of cysteamine, the only registered treatment for the rare genetic disease cystinosis, nine prodrugs of γ-glutamyl-cysteamine (4) were synthesized for evaluation.
Lisa Frost, Cannell, Stephanie, Pratap Suryadevara, Hambleton, Paul, Anderson, Rosaleen, Stephanie J. Cannell, Paul A. Hambleton, Frost, Lisa, Suryadevara, Pratap, Paul W. Groundwater, Groundwater, Paul, Rosaleen J. Anderson   +11 more
core   +1 more source

Efficient water‐soluble blue/red‐emissive carbon dots matching plant absorption spectra: Synthesis, tunable control, and their applications in promoting plant growth

Responsive Materials, EarlyView.
Guided by the spectral demand of plant photosystems, this review summarizes the synthesis, emission regulation, dual‐emission design, and gram‐scale production of CDs for agricultural applications. Spectrally matched blue‐ and red‐emissive CDs enhance plant light utilization by converting underutilized light into photosynthetically active radiation and
Yijing Chen, Ziyue Mu, Haoran Zhang, Xuejie Zhang, Wei Li, Bingfu Lei   +5 more
wiley   +1 more source

2D van der Waals System Integrated with Targeting Radio‐Diagnostic and Imaging Functions

Small, EarlyView.
Layered double hydroxide (LDH) nanoplates were engineered for tumor‐targeted imaging and therapy. By exploiting folate receptor (FR) expression levels, the system achieves selective tumor accumulation and high‐resolution dual PET/fluorescence (PET/FL) imaging.
Sairan Eom, Jae Hun Ahn, Jung Yung Kim, Kyo Chul Lee, Yong Jin Lee, Sanoj Rejinold N, Jin‐Ho Choy   +6 more
wiley   +1 more source

Low Sunscreen Awareness and Misconceptions in Skin of Colour With Acne‐Related Post‐Inflammatory Hyperpigmentation: A Cross‐Sectional Study Highlighting the Need for Targeted Education

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Background/Objectives Post‐inflammatory hyperpigmentation (PIH) is a frequent sequela of acne in patients with skin of colour (SOC). While sunscreen is widely recommended for PIH prevention, little is known about real‐world sunscreen practices in this group. This study aimed to evaluate sunscreen use, barriers and factors influencing adherence
Xiaozhun Hang, Davin Sui Lim, Lisa Byrom
wiley   +1 more source

Expert Consensus on the Management of Hyperpigmentation Disorders in India: A Modified Delphi Study by the Pigmentary Disorders Society

International Journal of Dermatology, EarlyView.
Delphi‐based expert consensus for diagnosis and management of common hyperpigmentation disorders in Indian dermatology practice, integrating evidence review, iterative voting, and consensus‐driven recommendations. ABSTRACT Hyperpigmentation disorders are prevalent in individuals with skin of color and are associated with considerable psychosocial ...
Rashmi Sarkar, Sunil Dogra, Surabhi Sinha, Keshavamurthy Vinay, Indrashis Podder, Anupam Das, Bhavesh Swarnkar, B. S. Chandrashekar, Hitaishi Mehta, Madhuri Agarwal, Muthu Sendhil Kumaran, Sonali Langar, Seemal R. Desai   +12 more
wiley   +1 more source