Ophthalmology and Therapy, 2019 Introduction Treatment of the anterior segment problems in cystinosis is challenging as oral cysteamine is ineffective in the treatment of corneal problems because of its avascular structure.
Freya Peeters +5 more
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Facile synthesis of cooperative acid-base catalysts by clicking cysteine and cysteamine on an ethylene-bridged periodic mesoporous organosilica [PDF]
, 2016 A periodic mesoporous organosilica (PMO) that contains ethylene bridges was functionalized to obtain a series of cooperative acid-base catalysts. A straightforward, single-step procedure was devised to immobilize cysteine and cysteamine on the support ...
Esquivel Merino, Maria Dolores +6 more
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Synthesis of diacylated γ-glutamyl-cysteamine prodrugs, and in vitro evaluation of their cytotoxicity and intracellular delivery of cysteamine [PDF]
, 2015 To overcome the major disadvantages of cysteamine, the only registered treatment for the rare genetic disease cystinosis, nine prodrugs of γ-glutamyl-cysteamine (4) were synthesized for evaluation.
Anderson, Rosaleen +5 more
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Metabolomic analysis of human oral cancer cells with adenylate kinase 2 or phosphorylate glycerol kinase 1 inhibition. [PDF]
, 2017 The purpose of this study was to use liquid chromatography-mass spectrometry (LC-MS) with XCMS for a quantitative metabolomic analysis of UM1 and UM2 oral cancer cells after knockdown of metabolic enzyme adenylate kinase 2 (AK2) or phosphorylate glycerol
Cheng, Siliangyu +6 more
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PLoS ONE, 2020 BackgroundEmerging data suggests a possible role for cysteamine as an adjunct treatment for pulmonary exacerbations of cystic fibrosis (CF) that continue to be a major clinical challenge.
Graham Devereux +18 more
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Cysteamine-mediated clearance of antibiotic-resistant pathogens in human cystic fibrosis macrophages. [PDF]
PLoS ONE, 2017 Members of the Burkholderia cepacia complex are virulent, multi-drug resistant pathogens that survive and replicate intracellularly in patients with cystic fibrosis (CF). We have discovered that B. cenocepacia cannot be cleared from CF macrophages due to
Chandra L Shrestha +8 more
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Improved method for the preparation of malonyl coenzyme A
Journal of Lipid Research, 1968 Malonyl coenzyme A is synthesized by transacylating S-malonyl-N-decanoyl cysteamine with coenzyme A. A simplified procedure for the preparation of S-malonyl-N-decanoyl cysteamine, using cysteamine as starting material, is described.
Hans Mohrhauer +4 more
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The specificity of cysteamine oxygenase
FEBS Letters, 1975 Oxidation of cysteamine to hypotaurine is catalyzed by cysteamine oxygenase (EC 1.13.11.19), a non-heme iron enzyme of large distribution [l-3] . A similar oxidation of cysteine to cysteine sulfinic acid has been reported to require a different oxygenase [4,.5]. Specificity of cysteamine oxygenase has been studied earlier in this laboratory by assaying
Cavallini, D. +5 more
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A monoclinic polymorph of cysteamine hydrochloride [PDF]
Acta Crystallographica Section E Structure Reports Online, 2009 cloruro de 2-mercaptoetano-aminio), C(2)H(8)NS(+)·Cl(-), la sal de hidrocloruro de cisteamina, en contraste con el polimorfo triclínico previamente informado [Kim et al. (2002▶). Polyhedron, 21, 225-228], cristalizado en el sistema cristalino monoclínico.
Saeed Ahmad +2 more
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Controlled Synthesis of Silver Nanoparticles Using Double Reductants and Its Voltammetric Characteristics Study [PDF]
, 2016 Constructing robust silver nanoparticles (AgNPs) with good shape and dispersibility is of particular interest in analytical applications. Herein, monodispersibility AgNPs with the average size of 20 nm have been successfully prepared via one-pot method ...
Duan, Yubo, Jiang, Xiaochun, Xu, Zhihua
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