Ophthalmology and Therapy, 2019 Introduction Treatment of the anterior segment problems in cystinosis is challenging as oral cysteamine is ineffective in the treatment of corneal problems because of its avascular structure.
Freya Peeters +5 more
doaj +1 more source
Effect of cysteamine and 13-cis-retinoic acid on bovine in vitro embryo production [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2018 One of the main factors decreasing the success of an in vitro embryo production is oxidative stress-mediated reactive oxygen species resulting in cellular damages.
Abdolreza RANJBAR +2 more
doaj +1 more source
The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes [PDF]
, 2015 As a model of metabolic transformations of antiviral drug “Triazaverin” and its analogues‑2-alkylthio‑6-nitro‑1,2,4-triazolo[5,1-c][1,2,4]triazine‑7-ones 1a-d examined the oxidation of alkylthio groups to the corresponding sulfoxides 2a-d and sulfones 3a-
Medvedeva, N. P. +3 more
core +3 more sources
Remotely triggered scaffolds for controlled release of pharmaceuticals [PDF]
, 2013 Fe3O4-Au hybrid nanoparticles (HNPs) have shown increasing potential for biomedical applications such as image guided stimuli responsive drug delivery.
Hoskins, Clare +3 more
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Metabolomic analysis of human oral cancer cells with adenylate kinase 2 or phosphorylate glycerol kinase 1 inhibition. [PDF]
, 2017 The purpose of this study was to use liquid chromatography-mass spectrometry (LC-MS) with XCMS for a quantitative metabolomic analysis of UM1 and UM2 oral cancer cells after knockdown of metabolic enzyme adenylate kinase 2 (AK2) or phosphorylate glycerol
Cheng, Siliangyu +6 more
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Improved method for the preparation of malonyl coenzyme A
Journal of Lipid Research, 1968 Malonyl coenzyme A is synthesized by transacylating S-malonyl-N-decanoyl cysteamine with coenzyme A. A simplified procedure for the preparation of S-malonyl-N-decanoyl cysteamine, using cysteamine as starting material, is described.
Hans Mohrhauer +4 more
doaj +1 more source
PLoS ONE, 2020 BackgroundEmerging data suggests a possible role for cysteamine as an adjunct treatment for pulmonary exacerbations of cystic fibrosis (CF) that continue to be a major clinical challenge.
Graham Devereux +18 more
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Cysteamine ophthalmic hydrogel for the treatment of ocular cystinosis [PDF]
Farmacia Hospitalaria, 2017 Ocular cystinosis is a rare disease characterised by the deposit of cystine crystals on the corneal surface, which hinder patients’ eyesight. Oral cysteamine is given as cysteamine; however, it does not reach the cornea due to the lack of corneal ...
Anxo Fernández-Ferreiro +9 more
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A monoclinic polymorph of cysteamine hydrochloride [PDF]
Acta Crystallographica Section E Structure Reports Online, 2009 cloruro de 2-mercaptoetano-aminio), C(2)H(8)NS(+)·Cl(-), la sal de hidrocloruro de cisteamina, en contraste con el polimorfo triclínico previamente informado [Kim et al. (2002▶). Polyhedron, 21, 225-228], cristalizado en el sistema cristalino monoclínico.
Saeed Ahmad +2 more
openaire +3 more sources
Cysteamine-mediated clearance of antibiotic-resistant pathogens in human cystic fibrosis macrophages. [PDF]
PLoS ONE, 2017 Members of the Burkholderia cepacia complex are virulent, multi-drug resistant pathogens that survive and replicate intracellularly in patients with cystic fibrosis (CF). We have discovered that B. cenocepacia cannot be cleared from CF macrophages due to
Chandra L Shrestha +8 more
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