Results 21 to 30 of about 20,732 (256)

The cytotoxic effect of cysteamine and its combinations with various endodontic intracanal medications on fibroblast cells: in vitro study

Bulletin of the National Research Centre, 2023
Background This study was established to assess cysteamine’s cytotoxic effect alone and in combination with various intracanal medications on fibroblast cells, because the biocompatibility of intracanal medication is considered one of the main factors ...
Esraa Adel Mohamed Abd Elhameed ElGammal, Abeer Hashem Mahran, Salma Hassan El Ashry, Sara Hossam Fahmy   +3 more
doaj   +1 more source

Cysteamine Decreases Low‐Density Lipoprotein Oxidation, Causes Regression of Atherosclerosis, and Improves Liver and Muscle Function in Low‐Density Lipoprotein Receptor–Deficient Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background We have shown previously that low‐density lipoprotein (LDL) can be oxidized in the lysosomes of macrophages, that this oxidation can be inhibited by cysteamine, an antioxidant that accumulates in lysosomes, and that this drug decreases ...
Feroz Ahmad, Robert D. Mitchell, Tom Houben, Angela Palo, Tulasi Yadati, Andrew J. Parnell, Ketan Patel, Ronit Shiri‐Sverdlov, David S. Leake   +8 more
doaj   +1 more source

A new proof of evidence of cysteamine quantification for therapeutic drug monitoring in patients with cystinosis

Orphanet Journal of Rare Diseases, 2022
Background To date, measurement of intracellular cystine is used for the therapeutic monitoring of patients affected by cystinosis in treatment with cysteamine.
Martina Franzin, Silvia Rossetto, Rachele Ruoso, Rossella Del Savio, Gabriele Stocco, Giuliana Decorti, Riccardo Addobbati   +6 more
doaj   +1 more source

Impact of Dietary Supplementation of Cysteamine on Egg Taurine Deposition, Egg Quality, Production Performance and Ovary Development in Laying Hens

Animals, 2023
This study aimed to examine the effect of dietary cysteamine on yolk taurine content in hens during different egg production periods. In Exp. 1, China Agricultural University-3 (CAU-3) hens at the peak stage of egg production (aged 31 wks) were used to ...
Jing Chen, Youli Wang, Zhenhai Tang, Xiaorui Guo, Jianmin Yuan   +4 more
doaj   +1 more source

Challenges for cysteamine stabilization, quantification, and biological effects improvement

Journal of Pharmaceutical Analysis, 2020
The aminothiol cysteamine, derived from coenzyme A degradation in mammalian cells, presents several biological applications. However, the bitter taste and sickening odor, chemical instability, hygroscopicity, and poor pharmacokinetic profile of ...
Carla Atallah, Catherine Charcosset, Hélène Greige-Gerges   +2 more
doaj   +1 more source

Effects of Coated Cysteamine on Oxidative Stress and Inflammation in Weaned Pigs

Animals, 2021
This study aimed to explore the effects of dietary coated cysteamine on oxidative stress and inflammation in diquat-induced weaning pigs. Twenty-four pigs were randomly assigned to three dietary groups with eight replicates: the control (fed base diet ...
Shanshan Wang, Miaomiao Bai, Kang Xu, Yirui Shao, Zhe Yang, Xia Xiong, Ruilin Huang, Yao Li, Hongnan Liu   +8 more
doaj   +1 more source

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation [PDF]

, 2014
Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures
Amin R, Andrea Venerando, Angela Sepe, Anil Mehta, Anna Bossi, Anna Zolin, Antonella Tosco, Boyle MP BS, Carlo A Leone, Daniela De Stefano, Donaldson S., Fabiola De Gregorio, Fischer H, Gianni Bona, Gibson LE, Giuseppe De Rosa, Guido Kroemer, Illek B, Jayaraman S, Kerem B, Kerem Eithan HMO, Laura Salvadori, Legssyer R, Lorenzo A Pinna, Luigi Maiuri, Lukacs G, Maria C Maiuri, Massimo Pettoello-Mantovani, Masvidal L, Pharmaceuticals Cylene, Pharmaceuticals Cylene, Rosa Grassia, Speranza Esposito, Standardization of Spirometry, Stefano Guido, Stern M, Valeria R Villella, Valeria Raia, van Doorninck JH, Villella VR   +39 more
core   +4 more sources

Cysteamine as a Future Intervention in Cystic Fibrosis Against Current and Emerging Pathogens: A Patient-based ex vivo Study Confirming its Antimicrobial and Mucoactive Potential in Sputum

EBioMedicine, 2015
Background: Cysteamine has recently been shown to have in vitro properties potentially therapeutically beneficial in cystic fibrosis (CF). In this study we investigated the antimicrobial and mucolytic activity of cysteamine against the complex biologic ...
Graham Devereux, Douglas Fraser-Pitt, Jennifer Robertson, Edward Devlin, Derry Mercer, Deborah O'Neil   +5 more
doaj   +1 more source

Effect of cysteamine and 13-cis-retinoic acid on bovine in vitro embryo production [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2018
One of the main factors decreasing the success of an in vitro embryo production is oxidative stress-mediated reactive oxygen species resulting in cellular damages.
Abdolreza RANJBAR, Mohammad Amin ESLAMPOUR, Mehran Farhoodi MOGHADAM   +2 more
doaj   +1 more source

Studies on the acylation of 4-(2-aminoethylthio)-7-nitrobenzofurazan: the role of bases in promoting the formation of fluorescent S-acyl derivatives through S–N Smiles rearrangement [PDF]

, 2012
The acylation of 4-(2-aminoethylthio)-7-nitrobenzofurazan has been investigated. Depending on the use of the base, a competitive Smiles rearrangement occurs during the acylation step leading to the formation of N-acyl and/or fluorescent S-acyl ...
Ah-Kow, Al-Kaysi, Allen, Bem, Borisenko, Buncel, Burchfield, Castagnolo, Daniele Castagnolo, Ferguson, Fu, Ghosh, Ioannis, Lavis, Mafalda Pagano, Martina Bernardini, Maurizio Botta, Numasawa, Radi, Radi, Shipton, Terrier, Uchiyama, Uchiyama, Uchiyama, Uchiyama, Warren, Wieland   +27 more
core   +1 more source