Results 21 to 30 of about 25,803 (305)

Maternal supply of cysteamine alleviates oxidative stress and enhances angiogenesis in porcine placenta

Journal of Animal Science and Biotechnology, 2021
Oxidative stress in placenta is associated with the occurrence of adverse pregnancy outcomes in sow, but there are few satisfactory treatment strategies for these conditions.
Shuangbo Huang, Zifang Wu, Zihao Huang, X. Hao, Long-ye Zhang, Chengjun Hu, Jianfu Wei, Jinping Deng, Chengquan Tan   +8 more
semanticscholar   +1 more source

A new nickel-based co-crystal complex electrocatalyst amplified by NiO dope Pt nanostructure hybrid; a highly sensitive approach for determination of cysteamine in the presence of serotonin

Scientific Reports, 2020
A highly sensitive electrocatalytic sensor was designed and fabricated by the incorporation of NiO dope Pt nanostructure hybrid (NiO–Pt–H) as conductive mediator, bis (1,10 phenanthroline) (1,10-phenanthroline-5,6-dione) nickel(II) hexafluorophosphate (B,
H. Karimi-Maleh, F. Karimi, Yasin Orooji, G. Mansouri, A. Razmjou, A. Aygun, F. Sen   +6 more
semanticscholar   +1 more source

Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis

EMBO Molecular Medicine, 2021
Nephropathic cystinosis is a severe monogenic kidney disorder caused by mutations in CTNS, encoding the lysosomal transporter cystinosin, resulting in lysosomal cystine accumulation. The sole treatment, cysteamine, slows down the disease progression, but
A. Jamalpoor, Charlotte A. G. H. van Gelder, F. Y. Yousef Yengej, E. Zaal, S. P. Berlingerio, K. Veys, Carla Pou Casellas, Koen Voskuil, Khaled Essa, C. Ammerlaan, L. Rega, Reini E N van der Welle, M. Lilien, M. Rookmaaker, H. Clevers, J. Klumperman, E. Levtchenko, C. Berkers, M. Verhaar, M. Altelaar, R. Masereeuw, M. Janssen   +21 more
semanticscholar   +1 more source

Cysteamine mitigates torsion/detorsion‐induced reperfusion injury via inhibition of apoptosis, oxidative stress and inflammatory responses in experimental rat model

Andrologia, 2021
Oxidative stress, inflammation and apoptosis are major pathways in pathophysiology of testicular torsion/detorsion (TTDT) reperfusion injury. This study evaluated the antioxidant, anti‐inflammatory and anti‐apoptotic role of cysteamine in TTDT‐induced ...
O. Afolabi, B. Alabi, T. Omobowale, Olufemi I. Oluranti, Olugbenga E. Iwalewa   +4 more
semanticscholar   +1 more source

Mechanisms for the Cytotoxicity of Cysteamine [PDF]

Toxicological Sciences, 2001
The major aim of this study was to quantitatively assess the contribution of H2O2 generation to the cytotoxicity induced by cysteamine. Cysteamine produces H2O2 at levels that correlate with its toxicity between 23 and 160 microM. A maximum of 6.9 microM H2O2 is generated by 625 microM cysteamine.
David A. Lawrence, Thomas M. Jeitner
openaire   +3 more sources

The Crystal Structure of Cysteamine Dioxygenase Reveals the Origin of the Large Substrate Scope of This Vital Mammalian Enzyme.

Biochemistry, 2021
We report the crystal structure of the mammalian non-heme iron enzyme cysteamine dioxygenase (ADO) at 1.9 Å resolution, which shows an Fe and three-histidine (3-His) active site situated at the end of a wide substrate access channel. The open approach to
R. L. Fernandez, Laura D Elmendorf, Roger W. Smith, C. Bingman, B. Fox, T. Brunold   +5 more
semanticscholar   +1 more source

A new proof of evidence of cysteamine quantification for therapeutic drug monitoring in patients with cystinosis

Orphanet Journal of Rare Diseases, 2022
Background To date, measurement of intracellular cystine is used for the therapeutic monitoring of patients affected by cystinosis in treatment with cysteamine.
Martina Franzin, Silvia Rossetto, Rachele Ruoso, Rossella Del Savio, Gabriele Stocco, Giuliana Decorti, Riccardo Addobbati   +6 more
doaj   +1 more source

Copper-Cysteamine Nanoparticles as a Heterogeneous Fenton-Like Catalyst for Highly Selective Cancer Treatment.

ACS Applied Bio Materials, 2020
Herein, for the first time, we report copper-cysteamine (Cu-Cy) nanoparticles having Cu1+ instead of Cu2+ as an efficient heterogeneous Fenton-like catalyst for highly selective cancer treatment.
L. Chudal, N. Pandey, Jonathan B. Phan, Omar Johnson, Liang-wu Lin, Hongmei Yu, Yang Shu, Zhenzhen Huang, M. Xing, J. P. Liu, Mingli Chen, Wei Chen   +11 more
semanticscholar   +1 more source

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation [PDF]

, 2014
Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures
Amin R, Andrea Venerando, Angela Sepe, Anil Mehta, Anna Bossi, Anna Zolin, Antonella Tosco, Boyle MP BS, Carlo A Leone, Daniela De Stefano, Donaldson S., Fabiola De Gregorio, Fischer H, Gianni Bona, Gibson LE, Giuseppe De Rosa, Guido Kroemer, Illek B, Jayaraman S, Kerem B, Kerem Eithan HMO, Laura Salvadori, Legssyer R, Lorenzo A Pinna, Luigi Maiuri, Lukacs G, Maria C Maiuri, Massimo Pettoello-Mantovani, Masvidal L, Pharmaceuticals Cylene, Pharmaceuticals Cylene, Rosa Grassia, Speranza Esposito, Standardization of Spirometry, Stefano Guido, Stern M, Valeria R Villella, Valeria Raia, van Doorninck JH, Villella VR   +39 more
core   +3 more sources

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source