Low density lipoprotein oxidation by ferritin at lysosomal pH [PDF]
, 2018 Oxidation of low density lipoprotein (LDL) has been proposed to be involved in the pathogenesis of atherosclerosis. We have previously shown that LDL can be oxidised by iron in lysosomes.
Leake, David S., Ojo, Oluwatosin O.
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International Journal of Pharmaceutics, 2020 Despite the high aqueous solubility of cysteamine, its unpleasant organoleptic properties, hygroscopicity, instability in solutions, and poor pharmacokinetic profile are the main drawbacks that limit its use for medical and cosmetic purposes. In this study, cysteamine-loaded liposomes were prepared using the ethanol injection method.
Catherine Charcosset +2 more
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Cysteamine exerts in vitro antiviral activity against the SARS-CoV-2 Delta and Omicron variants
Cell Death Discovery, 2022 The novel SARS-CoV-2 variants of concern (VOC) represent a considerable global alarm because their mutations are known to affect transmissibility and cause immune escape.
Tonino Alonzi +9 more
doaj +1 more source
Characterisation and functionalisation of mechanically fractured graphene nanoribbons : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Nanoscience at Massey University, Manawatū, New Zealand [PDF]
, 2017 Graphene has been heralded as the supermaterial of the future, boasting incredibly high electron mobility, thermal conductivity, and physical strength – all contained within the world’s first true 2D material, only a single atom thick.
Brooke, Samuel James
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PPARα contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis [PDF]
, 2019 Sepsis‐associated acute kidney injury (AKI) is a significant problem in critically ill children and adults resulting in increased morbidity and mortality. Fundamental mechanisms contributing to sepsis‐associated AKI are poorly understood.
Bennion, Brock G +10 more
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Frontiers in ImmunologyObjectiveCysteamine, a drug approved to treat cystinosis, has been proposed as a host-directed therapy for M. tuberculosis (Mtb) and SARS-CoV-2. The impact of cysteamine on the immune responses has not been fully investigated.
Saeid Najafi-Fard +14 more
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Pharmaceutics, 2023 Background: Cystinosis is a rare genetic disorder characterized by the accumulation of cystine crystals in several tissues and organs causing, among others, severe eye symptoms.
Ana Castro-Balado +13 more
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A novel approach to enhancing cellular glutathione levels [PDF]
, 2008 20 pages, 9 figures, 1 table.-- PMID: 18702664 [PubMed].-- PMCID: PMC2644427.-- NIHMSID: NIHMS90383.-- Printed version published Nov 2008.Glutathione (GSH) and GSH-associated metabolism provide the major line of defense for the protection of cells from ...
Lewerenz, Jan +3 more
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Simple Synthesis Method and Characterizations of Aggregation-Free Cysteamine Capped PbS Quantum Dot
Applied Sciences, 2019 Quantum dots have diverse chemical properties with different ligands attached on the surface. The cysteamine has been used as a ligand for various quantum dots because it has high solubility in water, and it facilitates binding of quantum dot and gold ...
Daekyung Kang +4 more
doaj +1 more source
Cysteamine Inhibits Glycine Utilisation and Disrupts Virulence in Pseudomonas aeruginosa
Frontiers in Cellular and Infection Microbiology, 2021 Pseudomonas aeruginosa is a major opportunistic human pathogen which employs a myriad of virulence factors. In people with cystic fibrosis (CF) P. aeruginosa frequently colonises the lungs and becomes a chronic infection that evolves to become less ...
Douglas J. Fraser-Pitt +12 more
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