Results 61 to 70 of about 12,238 (214)

Evaluation of NACA and diNACA in human cystinosis fibroblast cell cultures as potential treatments for cystinosis

Orphanet Journal of Rare Diseases, 2022
Background Cystinosis is a rare autosomal recessive lysosomal storage disease, associated with high morbidity and mortality. Mutations in the CTNS gene disable a membrane protein responsible for the transport of cystine out of the lysosome.
Emma Hector, Donald Cairns, G. Michael Wall   +2 more
doaj   +1 more source

Quantitative Imaging of Human Hemoglobin Binding to Staphylococcus aureus With Single‐Molecule Resolution

Small, EarlyView.
Single‐molecule localization microscopy is exploited to quantify the number of hemoglobin copies bound to specific receptors on S. aureus wall. This quantification supports the design of a photoactive derivative of hemoglobin able to photo‐inactivate S.
Pietro Delcanale, Andrea Mussini, Òscar Gulías, Montserrat Agut, Melissa Berni, Stefano Pongolini, Stefano Bruno, Alessandro Casnati, Santi Nonell, Cristiano Viappiani, Stefania Abbruzzetti   +10 more
wiley   +1 more source

Formulation study of cysteamine microparticulate systems

, 2020
Cysteamine is clinically used for the treatment of nephropathic cystinosis and is orally administered as cysteamine bitartrate. The daily dose of cysteamine (Cystagon®) for treatment of cystinosis in paediatric patients is 50 mg/kg per day, shared in ...
ADORNI, GRETA
core   +1 more source

Immunomodulatory effects of cysteamine and its potential use as a host-directed therapy for tuberculosis

Frontiers in Immunology
ObjectiveCysteamine, a drug approved to treat cystinosis, has been proposed as a host-directed therapy for M. tuberculosis (Mtb) and SARS-CoV-2. The impact of cysteamine on the immune responses has not been fully investigated.
Saeid Najafi-Fard, Chiara Farroni, Linda Petrone, Anna Maria Gerarda Altera, Andrea Salmi, Valentina Vanini, Valentina Vanini, Gilda Cuzzi, Tonino Alonzi, Emanuele Nicastri, Gina Gualano, Fabrizio Palmieri, Mauro Piacentini, Mauro Piacentini, Delia Goletti   +14 more
doaj   +1 more source

Nanopore and Self‐Assembled Monolayer Engineering of l‐Lactate Oxidase Gold Electrodes for Enhanced l‐Lactate Biosensing

Small, EarlyView.
A tiered nanoporous gold biointerface enables site‐directed immobilization of His‐tagged lactate oxidase through a mixed self‐assembled monolayer, achieving high enzyme loading while preserving activity. The resulting bioelectrode provides sensitive and stable l‐lactate detection (0.12–3.0 mM, 75 µA mM−1 cm−2), demonstrating a modular strategy for high‐
Mislav Sušac, Samuel Graf, Lara‐Marie Novak, Elisabeth Hengge, Chao Zhong, Roland Würschum, Bernd Nidetzky   +6 more
wiley   +1 more source

Successful treatment of solar lentigines by topical application of stabilized cysteamine: A vehicle‐controlled, double‐blind randomized study

Health Science Reports
Background Solar lentigines are common hyperpigmented lesions typically appearing after 50 years of age and associated with negative psychological effects in affected individuals. Topical depigmenting products, such as hydroquinone and even the Kligman's
Nasrin Saki, Vahideh Modabber, Hengameh Kasraei, Behrooz Kasraee   +3 more
doaj   +1 more source

Thiol-SAM Concentration Effect on the Performance of Interdigitated Electrode-Based Redox-Free Biosensors

Micromachines
Despite the direct, redox-free and simple detection non-faradaic impedimetric biosensors offer, considerable optimizations are required to enhance their performance for the detection of various biomarkers. Non-faradaic EIS sensors’ performance depends on
Abdulaziz K. Assaifan
doaj   +1 more source

Electrochemical aptasensors for ultrasensitive multiplexed detection: Towards a new era of precision diagnostics and environmental monitoring

VIEW, EarlyView.
Electrochemical aptasensors are emerging as powerful platforms for precision diagnostics and environmental monitoring, owing to their high selectivity, programmability and compatibility with miniaturised systems. However, their broader application is constrained by limited signal intensity and challenges in reliable multiplexed detection.
Azadeh Abdi, Ngoan Thi Thao Nguyen, Riccardo Zulli, Jacopo Giaretta, Fariba Dehghani, Syamak Farajikhah   +5 more
wiley   +1 more source

Halitosis in cystinosis patients after administration of immediate-release cysteamine bitartrate compared to delayed-release cysteamine bitartrate [PDF]

, 2012
Halitosis due to dimethylsulfide (DMS) generation is a major side effect of cysteamine in the treatment of cystinosis. Recently, an enteric coated formulation of cysteamine bitartrate (RP103) administered twice daily was demonstrated to be non-inferior ...
Levtchenko, Elena, Rioux, Patrice, Besouw, Martine, Cornelissen, Elisabeth, Tangerman, Albert   +4 more
core   +1 more source

Expert Consensus on the Management of Hyperpigmentation Disorders in India: A Modified Delphi Study by the Pigmentary Disorders Society

International Journal of Dermatology, EarlyView.
Delphi‐based expert consensus for diagnosis and management of common hyperpigmentation disorders in Indian dermatology practice, integrating evidence review, iterative voting, and consensus‐driven recommendations. ABSTRACT Hyperpigmentation disorders are prevalent in individuals with skin of color and are associated with considerable psychosocial ...
Rashmi Sarkar, Sunil Dogra, Surabhi Sinha, Keshavamurthy Vinay, Indrashis Podder, Anupam Das, Bhavesh Swarnkar, B. S. Chandrashekar, Hitaishi Mehta, Madhuri Agarwal, Muthu Sendhil Kumaran, Sonali Langar, Seemal R. Desai   +12 more
wiley   +1 more source