Results 61 to 70 of about 18,063 (229)

Natural Aging of Biomaterials in Ambient and Physiological Environments

Advanced NanoBiomed Research, EarlyView.
Biomaterials used in biomedical applications can change their physical properties over time, even under ambient and physiological conditions. This review highlights key studies on the natural aging of materials ranging from soft hydrogels to metals and ceramics, emphasizing how time‐dependent changes influence function and performance.
Shuyu Zhang, Anne E. Staples
wiley   +1 more source

Cysteamine exerts in vitro antiviral activity against the SARS-CoV-2 Delta and Omicron variants

Cell Death Discovery, 2022
The novel SARS-CoV-2 variants of concern (VOC) represent a considerable global alarm because their mutations are known to affect transmissibility and cause immune escape.
Tonino Alonzi, Alessandra Aiello, Federica Repele, Laura Falasca, Massimo Francalancia, Anna Rosa Garbuglia, Giovanni Delogu, Emanuele Nicastri, Mauro Piacentini, Delia Goletti   +9 more
doaj   +1 more source

PPARα contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis [PDF]

, 2019
Sepsis‐associated acute kidney injury (AKI) is a significant problem in critically ill children and adults resulting in increased morbidity and mortality. Fundamental mechanisms contributing to sepsis‐associated AKI are poorly understood.
Bennion, Brock G, Djukovic, Danijel, Fei, Lin, Iwaki, Takuma, Liles, W. Conrad, Lynn, Jared C, Otinga, Cynthia, Raftery, Daniel, Standage, Stephen W, Stenson, Erin K, Wong, Hector R   +10 more
core   +2 more sources

Immunomodulatory effects of cysteamine and its potential use as a host-directed therapy for tuberculosis

Frontiers in Immunology
ObjectiveCysteamine, a drug approved to treat cystinosis, has been proposed as a host-directed therapy for M. tuberculosis (Mtb) and SARS-CoV-2. The impact of cysteamine on the immune responses has not been fully investigated.
Saeid Najafi-Fard, Chiara Farroni, Linda Petrone, Anna Maria Gerarda Altera, Andrea Salmi, Valentina Vanini, Valentina Vanini, Gilda Cuzzi, Tonino Alonzi, Emanuele Nicastri, Gina Gualano, Fabrizio Palmieri, Mauro Piacentini, Mauro Piacentini, Delia Goletti   +14 more
doaj   +1 more source

Evaluation of NACA and diNACA in human cystinosis fibroblast cell cultures as potential treatments for cystinosis

Orphanet Journal of Rare Diseases, 2022
Background Cystinosis is a rare autosomal recessive lysosomal storage disease, associated with high morbidity and mortality. Mutations in the CTNS gene disable a membrane protein responsible for the transport of cystine out of the lysosome.
Emma Hector, Donald Cairns, G. Michael Wall   +2 more
doaj   +1 more source

Efficacy and safety of cysteamine-isobionicamide complex in postinflammatory hyperpigmentation: A 16-week, randomized, double-blinded, vehicle-controlled trial

Dermatologica Sinica, 2023
Background: Postinflammatory hyperpigmentation (PIH) is a prevalent acquired hyperpigmentation disorder with significant psychosocial implications. Cysteamine has demonstrated notable efficacy and safety in treating hyperpigmentation disorders.
Rosalie Tzu-Li Liu, Tsung-Fu Tsai, Yi-Jing Lai, Chau Yee Ng   +3 more
doaj   +1 more source

Low density lipoprotein oxidation by ferritin at lysosomal pH [PDF]

, 2018
Oxidation of low density lipoprotein (LDL) has been proposed to be involved in the pathogenesis of atherosclerosis. We have previously shown that LDL can be oxidised by iron in lysosomes.
Leake, David S., Ojo, Oluwatosin O.
core   +1 more source

From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities

Pharmaceuticals, 2023
We reviewed gastric ulcer healing by dopamine considering several distinctive duodenal key points. Selye and Szabo describe the cysteamine-induced duodenal ulcer in rats as a duodenal stress ulcer in patients.
Predrag Sikiric, Alenka Boban Blagaic, Ivan Krezic, Helena Zizek, Luka Kalogjera, Ivan Maria Smoday, Vlasta Vukovic, Katarina Oroz, Helen Marie Chiddenton, Sara Buric, Marko Antunovic, Slaven Gojkovic, Sanja Strbe, Milena Skocic, Suncana Sikiric, Marija Milavic, Lidija Beketic Oreskovic, Antonio Kokot, Antun Koprivanac, Ivan Dobric, Marko Sever, Mario Staresinic, Lovorka Batelja Vuletic, Anita Skrtic, Sven Seiwerth   +24 more
doaj   +1 more source

Characterisation and functionalisation of mechanically fractured graphene nanoribbons : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Nanoscience at Massey University, Manawatū, New Zealand [PDF]

, 2017
Graphene has been heralded as the supermaterial of the future, boasting incredibly high electron mobility, thermal conductivity, and physical strength – all contained within the world’s first true 2D material, only a single atom thick.
Brooke, Samuel James
core  

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source