Accelerating Biosensor Discovery: A Computationally‐Driven Pipeline for Microplastics Monitoring
Advanced Intelligent Discovery, EarlyView.A computationally guided pipeline unites molecular simulation, synthetic biology, electrochemical engineering, and machine learning to accelerate biosensor discovery. A Bacillus anthracis carbohydrate‐binding module is used to develop a high‐performance micro‐ and nanoplastics sensor with greatly reduced error and variability.
Gabriel X. Pereira +13 more
wiley +1 more source
Frontiers in ImmunologyObjectiveCysteamine, a drug approved to treat cystinosis, has been proposed as a host-directed therapy for M. tuberculosis (Mtb) and SARS-CoV-2. The impact of cysteamine on the immune responses has not been fully investigated.
Saeid Najafi-Fard +14 more
doaj +1 more source
Orphanet Journal of Rare Diseases, 2022 Background Cystinosis is a rare autosomal recessive lysosomal storage disease, associated with high morbidity and mortality. Mutations in the CTNS gene disable a membrane protein responsible for the transport of cystine out of the lysosome.
Emma Hector +2 more
doaj +1 more source
Dermatologica Sinica, 2023 Background: Postinflammatory hyperpigmentation (PIH) is a prevalent acquired hyperpigmentation disorder with significant psychosocial implications. Cysteamine has demonstrated notable efficacy and safety in treating hyperpigmentation disorders.
Rosalie Tzu-Li Liu +3 more
doaj +1 more source
Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel [PDF]
, 2019 Pentameric ligand-gated ion channels (pLGICs) are essential determinants of synaptic transmission, and are modulated by specific lipids including anionic phospholipids.
Brannigan, Grace +7 more
core +1 more source
Cysteamine exerts in vitro antiviral activity against the SARS-CoV-2 Delta and Omicron variants
Cell Death Discovery, 2022 The novel SARS-CoV-2 variants of concern (VOC) represent a considerable global alarm because their mutations are known to affect transmissibility and cause immune escape.
Tonino Alonzi +9 more
doaj +1 more source
Halitosis in cystinosis patients after administration of immediate-release cysteamine bitartrate compared to delayed-release cysteamine bitartrate [PDF]
, 2012 Halitosis due to dimethylsulfide (DMS) generation is a major side effect of cysteamine in the treatment of cystinosis. Recently, an enteric coated formulation of cysteamine bitartrate (RP103) administered twice daily was demonstrated to be non-inferior ...
Besouw, Martine +4 more
core +1 more source
Cysteamine: Clinical efficacy, safety and tolerability versus best-in-class treatments for melasma [PDF]
, 2021 Seemal R. Desai
openalex +1 more source
Simple Synthesis Method and Characterizations of Aggregation-Free Cysteamine Capped PbS Quantum Dot
Applied Sciences, 2019 Quantum dots have diverse chemical properties with different ligands attached on the surface. The cysteamine has been used as a ligand for various quantum dots because it has high solubility in water, and it facilitates binding of quantum dot and gold ...
Daekyung Kang +4 more
doaj +1 more source
Synthesis, X-ray Structures, Electronic Properties, and O\u3csub\u3e2\u3c/sub\u3e/NO Reactivities of Thiol Dioxygenase Active-Site Models [PDF]
, 2016 Mononuclear non-heme iron complexes that serve as structural and functional mimics of the thiol dioxygenases (TDOs), cysteine dioxygenase (CDO) and cysteamine dioxygenase (ADO), have been prepared and characterized with crystallographic, spectroscopic ...
Brunold, Thomas C. +4 more
core +1 more source