Results 71 to 80 of about 25,149 (297)

Self-assembled monolayers with biospecific affinity for lactate dehydrogenase for the electroenzymatic oxidation of lactate [PDF]

, 1997
Surface modified gold electrodes with high biospecific affinity for NAD(H)-dependent lactate dehydrogenase have been prepared by covalent attachment of several traizine dyes to stepwise functionalized mixed alkanethiol self-assembled monolayers.
Kooyman, Rob P.H., Schlereth, Daniela D.
core   +2 more sources

Detailed mechanistic investigation into the S-nitrosation of cysteamine [PDF]

Canadian Journal of Chemistry, 2012
The nitrosation of cysteamine (H2NCH2CH2SH) to produce cysteamine-S-nitrosothiol (CANO) was studied in slightly acidic medium by using nitrous acid prepared in situ. The stoichiometry of the reaction was H2NCH2CH2SH + HNO2 → H2NCH2CH2SNO + H2O.
Reuben H. Simoyi, Reuben H. Simoyi, Moshood K. Morakinyo, Robert M. Strongin, Jonathan J. Abramson, Justin M. Hettick, Itai Chipinda, Bice S. Martincigh, Paul D. Siegel   +8 more
openaire   +3 more sources

Characterization of the nonheme iron center of cysteamine dioxygenase and its interaction with substrates

Journal of Biological Chemistry, 2020
Cysteamine dioxygenase (ADO) has been reported to exhibit two distinct biological functions with a nonheme iron center. It catalyzes oxidation of both cysteamine in sulfur metabolism and N-terminal cysteine-containing proteins or peptides, such as ...
Yifan Wang, I. Davis, Y. Chan, S. Naik, W. Griffith, Aimin Liu   +5 more
semanticscholar   +1 more source

State‐of‐the‐Art, Insights, and Perspectives for MOFs‐Nanocomposites and MOF‐Derived (Nano)Materials

Advanced Materials, EarlyView.
Different approaches to MOF‐NP composite formation, such as ship‐in‐a‐bottle, bottle‐around‐the‐ship and in situ one‐step synthesis, are used. Owing to synergistic effects, the advantageous features of the components of the composites are beneficially combined, and their individual drawbacks are mitigated.
Stefanos Mourdikoudis, Subhajit Dutta, Saqib Kamal, Sergio Gómez‐Graña, Isabel Pastoriza‐Santos, Stefan Wuttke, Lakshminarayana Polavarapu   +6 more
wiley   +1 more source

A novel treatment of cystic fibrosis acting on-target:cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR [PDF]

, 2016
We previously reported that the combination of two safe proteostasis regulators, cysteamine and epigallocatechin gallate (EGCG), can be used to improve deficient expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in patients ...
A Di Pasqua, A Luciani, A Luciani, A Mehta, A Sepe, A Tosco, A Venerando, AM Cantin, AM Jones, AMP Boyle, AS Verkman, B Bosch, B Illek, BW Ramsey, C A Leone, CE Wainwright, D Bilton, D De Stefano, D De Stefano, D Taylor-Robinson, DM Cholon, E Ferrari, F De Gregorio, F Emma, F Munkonge, F Ratjen, FJ Accurso, G Bona, G De Rosa, G Kroemer, G Stoll, G Veit, H Abdi, H Amano, H Corvol, H Fischer, I Sana, JH vanDoorninck, JL Jameson, JN Snouwaert, K De Boeck, K De Boeck, L Maiuri, L Maiuri, L Salvadori, LL Vanscoy, M C Maiuri, M Stern, MD Amaral, MD Amaral, MK Mansoura, ML DeMarco, NJ Schork, NT Awatade, P Buonpensiero, PB Davis, R Grassia, R Paine, RR Marchelletta, S Esposito, S Guido, S Jayaraman, S Lusa, V Gondzik, V Raia, VR Villella, WA Gahl, X Qu, X Wang   +68 more
core   +4 more sources

Recent Research in Ocular Cystinosis: Drug Delivery Systems, Cysteamine Detection Methods and Future Perspectives

Pharmaceutics, 2020
Cystinosis is a rare genetic disorder characterized by the accumulation of cystine crystals in different tissues and organs. Although renal damage prevails during initial stages, the deposition of cystine crystals in the cornea causes severe ocular ...
Ana Castro-Balado, C. Mondelo-García, I. Varela-Rey, Beatriz Moreda-Vizcaíno, J. Sierra-Sánchez, M. Rodríguez-Ares, Gonzalo Hermelo-Vidal, I. Zarra-Ferro, M. González-Barcia, E. Yebra-Pimentel, M. J. Giráldez-Fernández, F. Otero-Espinar, A. Fernández‐Ferreiro   +12 more
semanticscholar   +1 more source

Progress in Surface Plasmon and Other Resonance Biosensors for Biomedical Applications

Advanced Materials Technologies, EarlyView.
This is the shortened version: Recent advancements in surface plasmon resonance and other optical resonance biosensors for biomedical applications are presented. Advanced sensing strategies are examined for the detection of diverse analytes, integration of nanomaterials and machine learning, and emerging nonplasmonic modes like guided mode resonance ...
Faten Bashar Kamal Eddin, Houxin Fan, Zhenchao Liu, Paolo Donati, Youssef Amin, Yap Wing Fen, Junbo Liang, Pier Paolo Pompa, Sailing He   +8 more
wiley   +1 more source

Evaluation of NACA and diNACA in human cystinosis fibroblast cell cultures as potential treatments for cystinosis

Orphanet Journal of Rare Diseases, 2022
Background Cystinosis is a rare autosomal recessive lysosomal storage disease, associated with high morbidity and mortality. Mutations in the CTNS gene disable a membrane protein responsible for the transport of cystine out of the lysosome.
Emma Hector, Donald Cairns, G. Michael Wall   +2 more
doaj   +1 more source

Recent Advances in Xenes Based FET for Biosensing Applications

Advanced Science, EarlyView.
Xenes (monoelemental 2D materials like graphene, phosphorene, tellurene) enable ultrasensitive FET (Field‐Effect Transistor) biosensors due to their tunable bandgap, high carrier mobility, and large surface area. Advances in synthesis (CVD, MBE) and functionalization allow detection of DNA/RNA (via CRISPR‐Cas systems), proteins, small molecules, and ...
Huide Wang, Chen Wang, Yule Zhang, Ziqian Wang, Yihan Zhu, Yun Wang, Xiangqian Hong, Han Zhang, Ning Fan, Meng Qiu   +9 more
wiley   +1 more source

Cysteamine inhibits lysosomal oxidation of low density lipoprotein in human macrophages and reduces atherosclerosis in mice [PDF]

, 2019
Background and aims: We have shown previously that low density lipoprotein (LDL) aggregated by vortexing is internalised by macrophages and oxidised by iron in lysosomes to form the advanced lipid/protein oxidation product ceroid.
Ahmad, Ahmad, Bachmanov, Baglione, Berliner, Besouw M, Bouazza, Dabbagh, David S. Leake, Devlin, Dohil, Dohil, El-Saadani, Esterbauer, Feroz Ahmad, Firth, Garner, Gerry, Goldstein, Heinemann, Javed, Jezegou, Jürgens, Kalatzis, Karunakaran, Khoo, Kritharides, Kuo, Leake, Lee, Liu, Marathe, Min-Oo, Mitchinson, Negre-Salvayre, Ojo, Omran, Oorni, Paigen, Palinski, Peter D. Weinberg, Pisoni, Portman, Quinn, Rajavashisth, Ruuth, Satchell, Schissel, Singh, Singh, Siow, Sneck, Steinberg, Steinberg, Tangirala, Tennezé, Tricon, Tsimikas, Ueda, Walters, Walters, Wen, Wilkins, Williams, Williams, Xu, Yichuan Wen, Yin, Yin, Yu, Yuan, Zahra Mohri, Zhang, Öörni   +73 more
core   +1 more source