Results 121 to 130 of about 10,373 (179)

Cysteine Cathepsins and Drug Discovery: Knowns and Unknowns

Biochemistry (Moscow)
Abstract Cysteine cathepsins are a group of closely related proteolytic enzymes active at low pH. The most well-studied function of these enzymes is protein degradation within lysosomes. However, accumulating evidence suggests that cysteine cathepsins also function at physiological pH levels in other cellular ...
openaire   +2 more sources

Cysteine cathepsins L and X differentially modulate interactions between myeloid-derived suppressor cells and tumor cells. [PDF]

Cancer Immunol Immunother, 2020
Jakoš T, Pišlar A, Pečar Fonović U, Švajger U, Kos J.   +4 more
europepmc   +1 more source

Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model. [PDF]

EJNMMI Res, 2020
Suurs FV, Qiu SQ, Yim JJ, Schröder CP, Timmer-Bosscha H, Bensen ES, Santini JT, de Vries EGE, Bogyo M, van Dam GM.   +9 more
europepmc   +1 more source

Psyllid Cysteine Cathepsins Directly Cleave the Outer Membrane Protein BamD of Citrus Huanglongbing Pathogen. [PDF]

Plant Biotechnol J
Du Y, Bin Y, Yang J, Hu M, Jiang L, Su Q, Lin S, Qu L, Li Y, Wei T.   +9 more
europepmc   +1 more source

Cysteine cathepsins and autoimmune diseases: A bidirectional Mendelian randomization. [PDF]

Medicine (Baltimore)
Wu Y, Li Q, Lou Y, Zhou Z, Huang J.
europepmc   +1 more source

Evaluation of Inhibitory Effect of Self-Etch Adhesives Incorporated with Proanthocyanidin on Cysteine Cathepsins Present in Dentin Hybrid Layer Using Gelatin Zymography: An In vitro Study.

J Pharm Bioallied Sci, 2021
Senthamilselvan A, Ravikumar K, Mallikarjunan DY, Annadurai T, Samynathan M, Varshini RJ.   +5 more
europepmc   +1 more source

Expression and Clinical Implications of Cysteine Cathepsins in Gallbladder Carcinoma. [PDF]

Front Oncol, 2019
Mehra S, Panwar R, Thakur B, Yadav R, Kumar M, Singh R, Dash NR, Sahni P, Chauhan SS.   +8 more
europepmc   +1 more source

An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans. [PDF]

Int J Mol Sci
Matoušková Z, Orsághová K, Srb P, Pytelková J, Kukačka Z, Buša M, Hajdušek O, Šíma R, Fábry M, Novák P, Horn M, Kopáček P, Mareš M.   +12 more
europepmc   +1 more source

Human Cysteine Cathepsins Degrade Immunoglobulin G In Vitro in a Predictable Manner. [PDF]

Int J Mol Sci, 2019
Høglund RA, Torsetnes SB, Lossius A, Bogen B, Homan EJ, Bremel R, Holmøy T.   +6 more
europepmc   +1 more source

Elastolytic activity of cysteine cathepsins K, S, and V promotes vascular calcification. [PDF]

Sci Rep, 2019
Andrault PM, Panwar P, Mackenzie NCW, Brömme D.   +3 more
europepmc   +1 more source