Results 241 to 250 of about 189,208 (289)

Characterization of a multi-copy gene for a major stage-specific cysteine proteinase of Leishmania mexicana [PDF]

FEBS Letters, 1992
Imcpb, a gene from Leishmania mexicana that encodes a major cysteine proteinase in the parasite, has been cloned and sequenced. LmCPb is related more to cysteine proteinases from Trypanosoma brucel and Trypanosoma cruzi than to a previously characterized
Jeremy C. Mottram, Graham H Coombs, G H Coombs   +2 more
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Autodegradation of lysosomal cysteine proteinases

Biochemical and Biophysical Research Communications, 1987
Repeated injections of Ep-475, a potent cysteine proteinase inhibitor, into rats caused several-fold increase in the hepatic contents of the lysosomal cysteine proteinases cathepsin B, H and L and in the activities of other lysosomal hydrolases. The rates of degradation of these lysosomal enzymes, estimated by repeated injections of cycloheximide, were
E, Kominami, T, Tsukahara, Y, Bando, N, Katunuma   +3 more
openaire   +2 more sources

Cysteine proteinases of parasitic protozoa

Parasitology Today, 1990
Proteinases are involved with many processes in living organisms. In recent years, there has been increasing interest in elucidating the functions the enzymes perform in parasites. These studies have revealed that one class of proteinases, the cysteine proteinases, predominates in many parasitic protozoa.
M J, North, J C, Mottram, G H, Coombs
openaire   +2 more sources

Entamoeba invadens:Characterization of Cysteine Proteinases

Experimental Parasitology, 1996
Cysteine proteinases have a number of important functions in the life cycle of protozoan parasites. Based on our previous studies demonstrating the role of cysteine proteinases in invasion by Entamoeba histolytica, we evaluated the cysteine proteinases of E. invadens, a related protozoan which causes invasive disease of reptiles. E.
M, Sharma, K, Hirata, S, Herdman, S, Reed   +3 more
openaire   +2 more sources

Parasite cysteine proteinases

Perspectives in Drug Discovery and Design, 1996
Cysteine proteinases of protozoan and helminth parasites are considered to have a high potential as targets for novel antiparasite agents. This has stimulated research on the enzymes and a large body of data has now been accumulated. This Perspective provides an overview of the current situation, with recent advances being highlighted.
Colin D. Robertson, Graham H. Coombs, Michael J. North, Jeremy C. Mottram   +3 more
openaire   +1 more source

A cysteine proteinase cDNA from Trypanosoma brucei predicts an enzyme with an unusual C-terminal extension [PDF]

FEBS Letters, 1989
A cDNA for a Trypanosoma brucei cysteine proteinase has been cloned and sequenced. The deduced protein can be divided into four domains, based on homologies with other cysteine proteinases: the pre-, pro- and central regions show considerable homology to
Jeremy C. Mottram, J D Barry, Graham H Coombs   +2 more
exaly   +2 more sources

Evolution of Cysteine Proteinases in Eukaryotes

Molecular Phylogenetics and Evolution, 1994
Phylogenetic analyses of the major family of cysteine proteinases of eukaryotes revealed that this family has been characterized by numerous gene duplications, several of which occurred very early in eukaryote evolutionary history. For example, certain cysteine proteinases from plants and animals are homologous to each of the two cysteine proteinases ...
openaire   +2 more sources

IV. Cysteine proteinases

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1970
Abstract Papain (EC 3.4.4.10) is a proteolytic enzyme which is isolated from the Papaya, a common tropical tree. It is a sulphydryl enzyme and its SH group is required for enzymic activity. Papain as usually prepared (Kimmel & Smith 1954) contains only a small portion of active molecules. The majority of the molecules are inactive
J. Drenth, J.N. Jansonius, R. Koekoek, L.A.A. Sluyterman, B.G. Wolthers   +4 more
openaire   +1 more source

Cysteine proteinase inhibitor levels in semen

Clinical Biochemistry, 1986
New proteinase inhibitors have recently been found in seminal plasma which specifically inhibit cysteine proteinases such as ficin, papain, cathepsin H and cathepsin B. The inhibitors consist of two components, In-A and In-B, both of which are effective in native semen.
K, Minakata, M, Asano, O, Yonekawa
openaire   +2 more sources

Bombyx Cysteine Proteinase Inhibitor (BCPI) Homologous to Propeptide Regions of Cysteine Proteinases Is a Strong, Selective Inhibitor of Cathepsin L-like Cysteine Proteinases

Journal of Biochemistry, 2001
Bombyx cysteine proteinase inhibitor (BCPI) is a novel cysteine proteinase inhibitor. The protein sequence is homologous to the proregions of certain cysteine proteinases. Here we report the mechanism of its inhibition of several cysteine proteinases.
M, Kurata, Y, Yamamoto, S, Watabe, Y, Makino, K, Ogawa, S Y, Takahashi   +5 more
openaire   +2 more sources