Results 101 to 110 of about 778,605 (292)

Evaluation of the Relationship between Cystatin C Level in Whole Saliva and Chronic Periodontitis [PDF]

Journal of Mashhad Dental School
Introduction: Chronic periodontitis is an infectious disease resulting in inflammation in tooth supporting tissues, advanced attachment loss and bone loss.
Mohammad Hassan Najafi Neshli, Morteza Taheri, Hooshang Rafatpanah, Amir Moeintaghavi, Majid Reza Mokhtari, Maryam Mohammadzade Rezae, Fateme Farazi   +6 more
doaj  

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Early Trends in Cystatin C and Outcomes in Patients with Cirrhosis and Acute Kidney Injury

International Journal of Nephrology, 2014
Background. Acute kidney injury (AKI) is a common and severe complication in patients with cirrhosis. Progression of AKI to a higher stage associates with increased mortality.
Justin M. Belcher, Arun J. Sanyal, Guadalupe Garcia-Tsao, Naheed Ansari, Steven G. Coca, Michael G. Shlipak, Chirag R. Parikh   +6 more
doaj   +1 more source

Investigação sobre a adaptação do inseto praga de cereais Tenebrio molitor a inibidores de proteinases digestivas [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2010Nas larvas de Tenebrio molitor (verme do trigo) são encontrados variados tipos de proteinases ...
Alexandre, Daniel
core  

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Inhibition of B16 melanoma metastasis by overexpression of the cysteine proteinase inhibitor cystatin C

, 1999
Progression to metastasis has been correlated with increased cysteine proteinase activity for a number of tumour types. One mechanism of cysteine proteinase regulation in normal cells is by natural protease inhibitors, the cystatins.
Cox, J. L., Green, T. J., Darmani, N. A., Sexton, P. S.   +3 more
core   +1 more source

Human plasma kininogens are identical with α-cysteine proteinase inhibitors Evidence from immunological, enzymological and sequence data [PDF]

, 1985
Human high- and low-Mr kininogens were shown to be potent inhibitors of cysteine proteinases such as cathepsin L and papain (Ki = 17–48 pM). A strong immunological cross-reaction between the kininogens and low-Mr α-cysteine proteinase inhibitor from ...
Lottspeich, Friedrich, Joze Brzin, Kotnik, Matjaz, Werner Machleidt, Matjaz Kotnik, Friedrich Lottspeich, Ritonja, Anka, Werner Müller-Esterl, Vito Turk, Hans Fritz, Kellermann, Josef, Machleidt, Werner, Müller-Esterl, Werner, Brzin, Joze, Josef Kellermann, Fritz, Hans, Turk, Vito, Anka Ritonja   +17 more
core   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

Detection of a papaya cysteine proteinase inhibitor under different environmental conditions [PDF]

, 2012
M.Sc.Proteinases are involved in many cellular reactions involving protein degradation, such as degradation of storage proteins and protein degradation during senescence processes. Their action can be inhibited by proteinase inhibitors.
Bester, Christell
core   +1 more source

In silico analysis of isoquinoline alkaloids using Cathepsin L as target receptor for controlling metastasis

Discover Chemistry
Metastasis had been a challenging concern for the oncologists in the progressive state of cancer. ubiquitous lysosomal cysteine proteinase, cathepsin L which plays an important role in metastasis in a variety of cancer cells has been taken as a target ...
Poonam R. Inamdar, Iqrar Ahmad, Shashikant V. Bhandari, Parixit J. Bhandurge, Padmaja S. Kore, Neeta Rai, Kiran Patil   +6 more
doaj   +1 more source