Results 301 to 310 of about 47,940 (359)

Copper(II) Inhibition of the SARS‐CoV‐2 Main Protease

Natural Sciences, EarlyView.
Molecular Docking of Cu(II) Schiff‐Base Chelates to SARS‐CoV‐2 Mpro. Two distinct Cu(II) chelates (Cu(II)Lp and Cu(II)Lm) are shown docked within the active site pocket of the Mpro, interacting with key residues HIS 41 and CYS 145. ABSTRACT In an analysis of the structural stability of the coronavirus main protease (Mpro), we identified regions of the ...
Roberto A. Garza‐López, Liam Kwak, Andrew Chung, Gabriel L. Ancajas, John J. Kozak, Harry B. Gray   +5 more
wiley   +1 more source

Unveiling the Roles of Cysteine Proteinases F and W: From Structure to Pathological Implications and Therapeutic Targets. [PDF]

Cells
Zdravkova K, Mijanovic O, Brankovic A, Ilicheva PM, Jakovleva A, Karanovic J, Pualic M, Pualic D, Rubel AA, Savvateeva LV, Parodi A, Zamyatnin AA.   +11 more
europepmc   +1 more source

Development of phytotherapeutic nanoformulation containing Gypsophila eriocalyx and its evaluation as a candidate formulation for osteoporosis treatment on human bone marrow stem cells

Phytochemical Analysis, EarlyView.
Abstract Introduction Osteoporosis, one of the common bone diseases, manifests itself as a decrease in bone mass. Recently, the use of medicinal plants in the search for effective and low‐toxicity therapeutics for the prevention or treatment of osteoporosis has become a trending topic.
Sibel Kaymak, Ozan Baris Kurtur, Bahar Gok, Yasemin Budama‐Kilinc, Serda Kecel‐Gunduz, Ebru Özdemir Nath, Murat Kartal   +6 more
wiley   +1 more source

Review of Cathepsin K Inhibitor Development and the Potential Role of Phytochemicals. [PDF]

Molecules
Moon DO.
europepmc   +1 more source

Tissue‐Specific Regulation of Fatty Acid Metabolism in a Mouse Model of Isolated Complex I Deficiency

PROTEOMICS, EarlyView.
ABSTRACT Isolated complex I deficiency (ICD) is commonly associated with mitochondrial diseases and closely mimics subacute necrotising encephalomyelopathy. This disorder is characterised by metabolic perturbations that affect energy metabolism pathways, including fatty acid metabolism.
Sibonelo Glen Khumalo, Jeremie Zander Lindeque, Marianne Venter   +2 more
wiley   +1 more source

Profiling Cysteine Proteases Activities in Neuroinflammatory Cells. [PDF]

ChemMedChem
Agost-Beltrán L, Canseco-Rodríguez A, Schirmeister T, Rodríguez S, Sánchez-Pérez AM, González FV.   +5 more
europepmc   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

The Role of Metacaspases and Other Proteins Involved in the Apoptosis of <i>Leishmania:</i> Review Article. [PDF]

Iran J Parasitol
Aghaei M, Aghaei S, Shahmoradi Z, Hejazi SH.   +3 more
europepmc   +1 more source

Establishment of a Protocol for CE‐MS Based Peptidome Analysis of Human Saliva

PROTEOMICS, EarlyView.
ABSTRACT Proteins and peptides indicate physiological or pathological states and are investigated to identify markers to scrutinize health and disease surveillance. Saliva contains many proteins and peptides that could serve as biomarkers, offering a potential noninvasive approach for disease detection.
Carl‐Johan Törnhage, Björn Peters, Agnieszka Latosinska, Ioanna K. Mina, Marika Mokou, Harald Mischak, Justyna Siwy   +6 more
wiley   +1 more source

Inhibition of cysteine protease disturbs the topological relationship between bone resorption and formation in vitro. [PDF]

J Bone Miner Metab
Ono S, Tsuji N, Sakamoto T, Oguchi S, Nakamura T, Hoshi K, Hikita A.   +6 more
europepmc   +1 more source