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Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors
Antimicrobial Agents and Chemotherapy, 1996We evaluated the antimalarial effects of vinyl sulfone cysteine proteinase inhibitors. A number of vinyl sulfones strongly inhibited falcipain, a Plasmodium falciparum cysteine proteinase that is a critical hemoglobinase. In studies of cultured parasites, nanomolar concentrations of three vinyl sulfones inhibited parasite hemoglobin degradation ...
J L Klaus +5 more
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Human cystatin, a new protein inhibitor of cysteine proteinases
Biochemical and Biophysical Research Communications, 1984A new low-molecular weight protein inhibitor of cysteine proteinases, human cystatin, was isolated from sera of patients with autoimmune diseases. It inhibits papain, human cathepsin H and cathepsin B. According to its partially determined amino-acid sequence, human cystatin is highly homologous to egg white cystatin, but only distantly related to ...
Ursula Borchart +4 more
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Interaction of the cysteine proteinase inhibitor chicken cystatin with papain
Biochemistry, 1988The two forms of chicken cystatin, with different isoelectric points, that have been described previously were indistinguishable in analyses of amino- and carboxy-terminal residues, amino acid composition, and peptide maps. The two forms thus are highly similar and most likely differ only in an amide group or in a small charged substituent. The binding
H Jörnvall +3 more
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[46] Peptidyl diazomethanes as inhibitors of cysteine and serine proteinases
1994Publisher Summary This chapter highlights peptidyl diazomethanes as inhibitors of cysteine and serine proteinases. Peptidyl diazomethanes are peptide derivatives, and are ketones. As these inhibitors are cell permeable, they can be used for in vivo inactivation of cysteine proteinases.
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Acid Cysteine Proteinase Inhibitor in Cutaneous Lymphocytic Infiltrates
The American Journal of Dermatopathology, 1995Acid cysteine proteinase inhibitor (ACPI, cystatin A) is normally present in squamous epithelium and dendritic cells of lymphoid follicles. Its expression is altered both in proliferative and malignant squamous epithelium and in neoplastic lymphoid follicles.
Heikki J. Aho +5 more
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A cysteine proteinase inhibitor purified from apple fruit
Phytochemistry, 1998A cysteine proteinase inhibitor has been purified from immature fruit of Malus domestica (var. Royal Gala). The M(r) of this apple cystatin is estimated to be 10,700 by MALDI-TOF mass spectrometry, 11 300 by SDS-PAGE and 11,000 by gel filtration. It is a relatively strong inhibitor of papain with a Ki value of 0.21 nM and also inhibits ficin and ...
Stuart N Ryan +2 more
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A lysosomotropic polymeric inhibitor of cysteine proteinases
Journal of Controlled Release, 1986Ruth Duncan +4 more
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