Results 181 to 190 of about 53,318 (217)

Cysteinyl Leukotriene Production in Anaphylactic Reactions

International Archives of Allergy and Immunology, 2009
Anaphylactic reactions are systemic, potentially life-threatening allergic reactions. In several animal models, evidence has been presented that leukotrienes may be of major pathophysiological significance. The aim of the present study was to obtain information on cysteinyl leukotriene production in anaphylactic reactions in humans in vivo.
C, Denzlinger, C, Haberl, W, Wilmanns
openaire   +2 more sources

Effects of cysteinyl leukotrienes and leukotriene receptor antagonists on markers of inflammation

Journal of Allergy and Clinical Immunology, 2003
The understanding that asthma pathophysiology includes an inflammatory component has spurred the more aggressive use of anti-inflammatory therapies and created a need for effective tools to measure inflammation. Biomarkers of airway inflammation proposed are obtained by methods that are direct but highly invasive (bronchial biopsy, bronchoalveolar ...
Sampson, Anthony P., Pizzichini, Emilio, Bisgaard, Hans   +2 more
openaire   +3 more sources

Cysteinyl leukotrienes: biosynthesis and receptors

Clinical & Experimental Allergy Reviews, 2004
SummaryLTC4 synthase (LTC4S) catalyzes the conjugation of LTA4 with glutathione to form LTC4, the parent compound of the cysteinyl leukotrienes (cysLTs). LTC4S is an 18kD membrane protein that belongs to MAPEG superfamily. Mutational analysis of LTC4S indicates that Arg‐51 and Tyr‐93 are critical in enzyme catalysis.
B. Lam, Y. Kanaoka, J. Boyce, K. F. Austen   +3 more
openaire   +1 more source

Cysteinyl Leukotrienes in Allergic Inflammation

Chest, 2005
Systemically bioavailable leukotriene receptor antagonists (LTRAs) can reduce the essential components of allergic inflammation in allergic rhinitis (AR) and asthma by blocking cysteinyl leukotriene (CysLT) activity, resulting in a wide range of clinical effects. CysLTs, mediators, and modulators in the pathophysiology of asthma and AR are a key target
William Busse, Monica Kraft
openaire   +1 more source

Pathophysiology of the cysteinyl leukotrienes and effects of leukotriene receptor antagonists in asthma

Allergy, 2001
Cysteinyl leukotrienes, synthesized de novo from cell membrane phospholipids, are proinflammatory mediators that play an important role in the pathophysiology of asthma. These mediators are among the most potent of bronchoconstrictors and cause vasodilation, increased microvascular permeability, exudation of macromolecules and edema.
openaire   +2 more sources

Antagonism of cysteinyl leukotrienes and their receptors as a neuroinflammatory target in Alzheimer’s disease

Neurological Sciences, 2020
R. Singh
semanticscholar   +1 more source

Transport and Elimination of Cysteinyl Leukotrienes

1993
Primary-active, ATP-dependent, unidirectional export carriers mediate the release of cysteinyl eukotrienes from leukotriene-generating cells (as studied in mastocytoma cells) as well as cysteinyl leukotriene export from liver into bile. The ATP-dependent carrier for leukotrienes in the hepatocyte canalicular membrane is distinct from the bile salt ...
M. Müller, A. Guhlmann, K. Krauss, T. Schaub, C. Klünemann, U. Berger, D. Keppler   +6 more
openaire   +1 more source

Metabolism and excretion of cysteinyl-leukotrienes.

Advances in prostaglandin, thromboxane, and leukotriene research, 1987
In vitro and in vivo experiments have demonstrated that a major pathway of metabolism of the glutathione containing leukotrienes involves modifications of the tripeptide substituent. The metabolic alterations are initiated by elimination of the N-terminal gamma-glutamyl residue, catalyzed by the enzyme gamma-glutamyl transferase.
S, Hammarström, L, Orning, K, Bernström   +2 more
openaire   +1 more source

The role of cysteinyl leukotrienes and their receptors in refractory nasal polyps.

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2017
Jin-Tao Du, L. Ba, Jiao Zhou, Ling-Yu Yu, Ruo-Wu Liu, Jie Zhang, Feng Liu, J. Xian, Shi-Xi Liu, Yafeng Liu   +9 more
semanticscholar   +1 more source

Cysteinyl Leukotrienes (CysLTs): Role in Obesity-Induced Asthma.

Current molecular medicine, 2015
U. C. S. Yadav, Satish K. Srivastava
semanticscholar   +1 more source