Results 161 to 170 of about 53,318 (217)

Cysteinyl leukotriene receptors

Prostaglandins & Other Lipid Mediators, 2002
The cysteinyl leukotrienes, leukotriene C4 (LTC4), leukotriene D4 (LTD4) and leukotriene E4 (LTE4), activate contractile and inflammatory processes via specific interaction with putative seven transmembrane-spanning receptors that couple to G proteins and subsequent intracellular signaling pathways. Pharmacological characterizations identified at least
Yiqun, Hui, Colin D, Funk
openaire   +4 more sources

Levels of cysteinyl-leukotrienes in exhaled breath condensate are not due to saliva contamination

Clinical Respiratory Journal, 2010
Background and Aims: Saliva contamination has been suggested to be a major contributor to levels of cysteinyl leukotrienes in exhaled breath condensate (EBC).
Leif Bjermer, Ellen Tufvesson, Henrik Ekedahl   +2 more
exaly   +3 more sources

Role of Cysteinyl Leukotrienes in Allergic Rhinitis.

Advances in Oto-Rhino-Laryngology, 2016
Cysteinyl leukotrienes (CysLTs) are lipid mediators that have been implicated in the pathogenesis of allergic rhinitis. Pharmacological studies using CysLTs indicate that two classes of receptor exist: CysLT1 receptor (CysLT1R) and CysLT2 receptor (CysLT2R).
H. Shirasaki, T. Himi
semanticscholar   +3 more sources

5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer's disease.

Brain, behavior, and immunity, 2020
5-lipoxygenase (ALOX5) is an enzyme involved in arachidonic acid (AA) metabolism, a metabolic pathway in which cysteinyl leukotrienes (CysLTs) are the resultant metabolites.
Fang Chen, Arijit Ghosh, Jing-ran Lin, Chun-Teng Zhang, Yining Pan, A. Thakur, Kunal Singh, H. Hong, Su-Su Tang   +8 more
semanticscholar   +1 more source

Autocrine activity of cysteinyl leukotrienes in human vascular endothelial cells: Signaling through the CysLT₂ receptor.

Prostaglandins & other lipid mediators, 2015
We evaluated the autocrine activities of cysteinyl leukotrienes (cysteinyl-LTs) in HUVEC and studied the signaling and the pharmacological profile of the CysLT2 receptor (CysLT2R) expressed by ECs, finally assessing the role of the CysLT2R in ...
V. Capra, C. Carnini, M. Accomazzo, A. Di Gennaro, Marco Fiumicelli, E. Borroni, I. Brivio, C. Buccellati, P. Mangano, Silvia Carnevali, G. Rovati, A. Sala   +11 more
semanticscholar   +2 more sources

Cysteinyl-leukotrienes and the liver

Prostaglandins & Other Lipid Mediators, 2003
Leukotrienes are potent biological mediators implicated in an increasing number of disease processes. This review outlines the basic biology of leukotrienes and discusses recent developments in our understanding of the specific role of cysteinyl-leukotrienes (cLTs) in cholestasis, hepatic inflammation, portal hypertension, and the pathogenesis of the ...
Ramin, Farzaneh-Far, Kevin, Moore
openaire   +2 more sources

Roles of cysteinyl leukotrienes and their receptors in immune cell-related functions.

Advances in Immunology, 2019
The cysteinyl leukotrienes (cys-LTs), leukotriene C4, (LTC4), LTD4, and LTE4, are lipid mediators of inflammation. LTC4 is the only intracellularly synthesized cys-LT through the 5-lipoxygenase and LTC4 synthase pathway and after transport is metabolized
Y. Kanaoka, K. Austen
semanticscholar   +1 more source

Binding to Cysteinyl-Leukotriene Receptors

American Journal of Respiratory and Critical Care Medicine, 2000
It is widely accepted that leukotrienes (LTs) exert their actions through high-affinity specific receptors, although only the LTB 4 receptor has been cloned so far (1). Given the differences between the two classes of LTs (LTB 4 versus LTC 4 , LTD 4 , and LTE 4 , i.e., cysteine-containing leukotrienes or cysteinyl-LTs) in terms of both structure and ...
S. Nicosia, V. Capra, S. Ravasi, G.E. Rovati   +3 more
openaire   +3 more sources

Transport and in vivo elimination of cysteinyl leukotrienes

Advances in Enzyme Regulation, 1992
Transport processes control not only synthesis and release of LTC4 but also the elimination and excretion of LTC4 and its metabolites. (i) A primary-active ATP-dependent export carrier mediates the release of LTC4 from a leukotriene-generating cell, as exemplified by mastocytoma cells, and as measured in mastocytoma plasma membrane vesicles (2).
D, Keppler, M, Müller, C, Klünemann, A, Guhlmann, K, Krauss, J, Müller, U, Berger, I, Leier, E, Mayatepek   +8 more
  +7 more sources

Cysteinyl Leukotriene Receptor Assays

Current Protocols in Pharmacology, 2000
AbstractThe cysteinyl leukotrienes (CysLTs), LTC4, LTD4 and LTE4, lipid products derived from arachidonic acid metabolism, have been implicated in the pathophysiology of several inflammatory diseases, in particular, asthma. This unit describes techniques and applications for the measurement of contractile responses to the CysLTs in isolated smooth ...
R M, Muccitelli, M A, Luttmann, D W, Hay
openaire   +2 more sources