Results 171 to 180 of about 53,318 (217)

The cysteinyl leukotriene receptors

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2003
The cysteinyl leukotriene (CysLT) receptors are putative 7 transmembrane spanning G protein-coupled receptors (GPCRs) of the rhodopsin subfamily of GPCRs. Two human and mouse CysLT receptors have been molecularly cloned and characterized. The properties of these receptors agrees well with previous pharmacological CysLT agonist and antagonist ...
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Cysteinyl-Leukotrienes and the Human Lung

1999
Asthma is a chronic inflammatory disease of the airways involving recurrent airway obstruction. While the exact cause of this inflammation is presently unknown, allergen and locally released endogenous mediators play a crucial role in the severity and exacerbation of the symptoms associated with the disease.
I, Gorenne, C, Labat, X, Norel, J P, Gascard, C, Brink   +4 more
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Cysteinyl leukotrienes: multi-functional mediators in allergic rhinitis [PDF]

Clinical and Experimental Allergy, 2006
Cysteinyl leukotrienes (CysLTs) are a family of inflammatory lipid mediators synthesized from arachidonic acid by a variety of cells, including mast cells, eosinophils, basophils, and macrophages.
Alkis Togias, Marc Peters-Golden
exaly   +2 more sources

The Measurement of Cysteinyl Leukotrienes in Urine

2003
The cysteinyl leukotrienes, comprising leukotriene (LT) C4 and its major metabolites LTD4 and LTE4, are inflammatory lipid mediators derived from metabolism of arachidonic acid by 5-lipoxygenase. These leukotrienes have received considerable attention for their potential role in asthma and other inflammatory diseases.
J Y, Westcott, S E, Wenzel
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Transport of Cysteinyl Leukotrienes

1992
The cysteinyl leukotrienes comprise the metabolites formed from the glutathione conjugate leukotriene C4 (LTC4) in the mercapturate pathway as well as the ω- and s-oxidized catabolites derived from the cysteine conjugate LTE4 and from the —acetylcysteine conjugate N-acetyl—LTE4.
Dietrich Keppler, Michael Müller, Toshihisa Ishikawa   +2 more
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Cysteinyl Leukotrienes and Disease

2015
Cysteinyl leukotrienes (cys-LTs) are peptide-conjugated lipid inflammatory mediators generated predominantly by hematopoietic effector cells. Although they were originally recognized based on their capacity to potently induce vascular leakage and smooth muscle contraction, they are now known to elicit a wide range of effects on hematopoietic and ...
Laura B. Fanning, Joshua A. Boyce
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Capillary isotachophoretic determination of cysteinyl leukotrienes

Journal of Chromatography A, 1991
The cysteinyl leukotrienes (LTs) C4, D4 and E4 are among the most potent lipid mediators of anaphylaxis and inflammation. A capillary isotachophoretic method is described for the determination of these cysteinyl LTs. The method is based on anionic separation and detection using UV (254 nm) and conductivity detectors.
D, Tsikas, J, Fauler, G, Brunner, J C, Frölich   +3 more
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Receptors for Cysteinyl-Leukotrienes in Human Cells

1999
It is widely accepted that leukotrienes (LTs) exert their actions through high-affmity specific receptors, although none of these receptors has been cloned so far. Recently, the classification and nomenclature of LT receptors has been proposed by an ad hoc committee appointed by the International Union of Pharmacology (IUPHAR), and has been officially ...
S. Nicosia, V. Capra, M. Accomazzo, D. Ragnuni, S. Ravasi, A. Caiani, L. Jommi, R. Saponara, M. Mezzetti, G. Rovati   +9 more
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Cysteinyl leukotrienes undergo enterohepatic circulation

Prostaglandins, Leukotrienes and Medicine, 1986
Abstract Enterohepatic circulation is an important mechanism responsible for extension of the biological half-lives of many endogenous compounds and xenobiotics (1). Cysteinyl leukotrienes play an important role in lethal endotoxin action (2) and in tissue trauma (3).
C, Denzlinger, A, Guhlmann, W, Hagmann, P H, Scheuber, F, Scheyerl, D, Wilker, D K, Hammer, D, Keppler   +7 more
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Cysteinyl Leukotrienes in Chronic Hyperplastic Rhinosinusitis

Otolaryngology–Head and Neck Surgery, 2002
OBJECTIVESOur study was designed to demonstrate that, similar to asthma, eosinophilic chronic rhinosinusitis is a disease characterized by activation and the expression of cysteinyl leukotrienes (LTs).METHODSNasal polyp tissue was evaluated from 28 consecutive individuals undergoing elective polypectomy in whom neutrophils were not present on ...
Pablo, Arango, Larry, Borish, Henry F, Frierson, Stilianos E, Kountakis   +3 more
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