Results 141 to 150 of about 1,105,613 (399)

Real‐world population pharmacokinetics of tezacaftor‐ivacaftor in children with cystic fibrosis: The SYM‐CF study

British Journal of Clinical Pharmacology, EarlyView.
Aims The clinical effectiveness of tezacaftor‐ivacaftor in children with cystic fibrosis (cwCF) varies; some patients respond while others do not or have adverse effects. The pharmacokinetics (PK) of tezacaftor‐ivacaftor are inadequately published, especially in children.
Steffie E. M. Vonk, Suzanne W. J. Terheggen‐Lagro, Eric G. Haarman, Hettie M. Janssens, Anke‐Hilse Maitland–van der Zee, E. Marleen Kemper, Ron A. A. Mathôt, on behalf of the Amsterdam Mucociliary Clearance Disease (AMCD) research group   +7 more
wiley   +1 more source

Improving the Rate of Sufficient Sweat Collected in Infants Referred for Sweat Testing in Michigan

Global Pediatric Health, 2014
Objective . Sweat collected for testing should have quantity not sufficient (QNS) rate of ≤10% in babies ≤3 months of age. Michigan (MI) cystic fibrosis (CF) centers’ QNS rates were 12% to 25% in 2009. This project was initiated to reduce sweat QNS rates
Ibrahim Abdulhamid MD, Mary Kleyn MSC, Carrie Langbo MS, Myrtha Gregoire-Bottex MD, John Schuen MD, Krithika Shanmugasundaram BS, Samya Z Nasr MD   +6 more
doaj   +1 more source

The role of bacterial secretion systems in the virulence of Gram-negative airway pathogens associated with cystic fibrosis [PDF]

, 2016
Cystic fibrosis (CF) is the most common lethal inherited disorder in Caucasians. It is caused by mutation of the CF transmembrane conductance regulator (CFTR) gene.
Depluverez, Sofie, Devos, Simon, Devreese, Bart   +2 more
core   +2 more sources

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

Eradication of Burkholderia cepacia Using Inhaled Aztreonam Lysine in Two Patients with Bronchiectasis

Case Reports in Pulmonology, 2014
There are not many articles about the chronic bronchial infection/colonization in patients with underlying lung disease other than cystic fibrosis (CF), especially with non-CF bronchiectasis (NCFBQ). The prevalence of B. cepacia complex is not well known
A. Iglesias, I. Artiles, J. J. Cabanillas, R. Álvarez-Sala, C. Prados   +4 more
doaj   +1 more source

A Sodium Transport Inhibitory Factor in the Saliva of Patients with Cystic Fibrosis of the Pancreas [PDF]

, 1967
J. A. Mangos, Nona R. McSherry, P.J. Benke   +2 more
openalex   +1 more source

Light‐Enabled [2σ + 2π] Cycloadditions of Bicyclo[1.1.0]butanes and Alkenes by Ti‐Salen Photocatalysis

ChemistryEurope, EarlyView.
This study reports an unprecedented Ti(Salen)‐catalyzed [2σ+2π] photocycloaddition of bicyclo[1.1.0]butanes and alkenes, featuring broad substrate scope, excellent functional group tolerance, scalability, and potential pharmaceutical applications. Notably, this work represents the first application of a Ti(Salen) complex as an efficient photoredox ...
Jinping Xing, Dexia Li, Tianxiang Li, Yang Xu, Haosong Ren, Jun Zheng   +5 more
wiley   +1 more source

Exploring the utilisation and effectiveness of implementation science strategies by cystic fibrosis registries for healthcare improvement: a systematic review

European Respiratory Review
Background Cystic fibrosis (CF) registries capture important information in high-burden health domains to support improvement in health outcomes, although a number of unanswered questions persist, as follows.
Rob G. Stirling, Bhumika Sood, Macken J.L. Stirling, Tom Kotsimbos, Dominic T. Keating, Catherine E. Rang, James M. Trauer, Alan C. Young, Christiaan Yu, Julianna Bailey, Peter Wark, Angela Melder, Paul Dawkins   +12 more
doaj   +1 more source

Early diagnosis from newborn screening maximises survival in severe cystic fibrosis

ERJ Open Research, 2018
Newborn screening (NBS) for cystic fibrosis (CF) has been gradually established in several countries, but scant data are available on its long-term effects on survival. Our objective was to evaluate the long-term effects of CF NBS on survival.
Gloria Tridello, Carlo Castellani, Ilaria Meneghelli, Anna Tamanini, Baroukh M. Assael   +4 more
doaj   +1 more source

Transient Pulmonary Infiltrations in Cystic Fibrosis due to Allergic Aspergillosis [PDF]

, 1965
M B Mearns, Warren Young, J C Batten
openalex   +1 more source