Results 101 to 110 of about 27,857 (278)

The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.

Antioxidants and Redox Signaling, 2013
The antiporter system x(c)(-) imports the amino acid cystine, the oxidized form of cysteine, into cells with a 1:1 counter-transport of glutamate. It is composed of a light chain, xCT, and a heavy chain, 4F2 heavy chain (4F2hc), and, thus, belongs to the
J. Lewerenz, S. Hewett, Ying Huang, M. Lambros, P. Gout, P. Kalivas, A. Massie, I. Smolders, A. Methner, Mathias Pergande, Sylvia B. Smith, V. Ganapathy, P. Maher   +12 more
semanticscholar   +1 more source

Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation

Journal of Biological Chemistry, 2017
Oncogenic signaling in cancer cells alters glucose uptake and utilization to supply sufficient energy and biosynthetic intermediates for survival and sustained proliferation.
Takeo Goji, K. Takahara, M. Negishi, H. Katoh   +3 more
semanticscholar   +1 more source

Gas-Phase Fragmentation Reactions of Protonated Cystine using High-Resolution Tandem Mass Spectrometry

Molecules, 2019
Cystine is an important biomolecule in living systems. Although collision-induced dissociation (CID)-based tandem mass spectrometry (MS/MS) is commonly applied for identification and quantification of cystine in both biomedical and nutritional studies ...
Pengwei Zhang, Wan Chan, Irene L. Ang, Rui Wei, Melody M. T. Lam, Kate M. K. Lei, Terence C. W. Poon   +6 more
doaj   +1 more source

Selective, Simple and Economical Method for the Voltammetric Determination of Bi(III) in the presence Cystine in Non – Complexing Solution

E3S Web of Conferences, 2013
The simple and fast method for the determination of Bi(III) in non-complexing solution was proposed. The catalytic activity of cystine on Bi(III) ions electroreduction process were utilized.
Nosal –Wiercińska A., Grochowski M., Tyszczuk–Rotko K., Skrzypek S., Guziejewski D.   +4 more
doaj   +1 more source

Sulfur Amino Acids in Diet-induced Fatty Liver: A New Perspective Based on Recent Findings

Molecules, 2014
The relationship of sulfur amino acids to diet-induced fatty liver was established 80 years ago, with cystine promoting the condition and methionine preventing it.
John I. Toohey
doaj   +1 more source

Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets

Nature Communications, 2017
Protein:protein interactions are among the most difficult to treat molecular mechanisms of disease pathology. Cystine-dense peptides have the potential to disrupt such interactions, and are used in drug-like roles by every clade of life, but their study ...
Zachary R. Crook, Gregory P. Sevilla, D. Friend, M. Brusniak, A. Bandaranayake, Midori Clarke, M. Gewe, A. Mhyre, D. Baker, R. Strong, P. Bradley, J. Olson   +11 more
semanticscholar   +1 more source

Cell-Cycle-Associated Amplified Genomic-DNA Fragments (CAGFs) Might Be Involved in Chloroquine Action and Resistance in Plasmodium falciparum [PDF]

arXiv, 2017
As a cheap and safe antimalarial agent, chloroquine (CQ) has been used in the battle against malaria for more than half century. However, the mechanism of CQ action and resistance in Plasmodium falciparum remains elusive. Based on further analysis of our published experimental results, we propose that the mechanism of CQ action and resistance might be ...
arxiv  

Cystine addiction of triple negative breast cancer associated with EMT augmented death signaling

Oncogene, 2016
Despite the advances in the diagnosis and treatment of breast cancer, breast cancers still cause significant mortality. For some patients, especially those with triple-negative breast cancer, current treatments continue to be limited and ineffective ...
Xiaohu Tang, C. Ding, Jianli Wu, J. Sjol, S. Wardell, D. George, D. McDonnell, D. Hsu, Jeffrey T. Chang, J. Chi   +9 more
semanticscholar   +1 more source

Cysteamine hydrochloride eye drop solution for the treatment of corneal cystine crystal deposits in patients with cystinosis: an evidence-based review

Clinical Ophthalmology, 2018
Cystinosis is a rare, autosomal recessive disorder leading to defective transport of cystine out of lysosomes. Subsequent cystine crystal accumulation can occur in various tissues, including the ocular surface.
Achini Makuloluwa, F. Shams
semanticscholar   +1 more source

Organ toxicities associated with diet‐induced obesity in rats: Investigation of changes in activities selected enzymes

Biotechnology and Applied Biochemistry, EarlyView.
Abstract Obesity stands out as one of the most significant health problems in the modern world. The prevalence of high‐calorie diets (HCDs) globally exacerbates this condition. Throughout history, plants and plant‐derived food products have been utilized for medicinal purposes, demonstrating their efficacy in the treatment and prevention of various ...
Bedia Bati
wiley   +1 more source