Results 141 to 150 of about 55,240 (308)
Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges
The Chemical Record, EarlyView.Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley +1 more source
BJU International, EarlyView.Objective To evaluate the feasibility and performance of the StoneSense™ module (SSM; IPG Medical, Marlborough, MA, USA), a prototype real‐time target recognition unit integrated into a IPG Thulium Fiber Laser (TFL). Materials and Methods The SSM analyses the spectral signature of back reflected light‐emitting diode (LED) light from the target ...
Olivier Traxer +7 more
wiley +1 more source
MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities
Cancer Science, EarlyView.Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah +3 more
wiley +1 more source
Cancer Science, EarlyView.Elesclomol‐induced cuproptosis potently activates both innate and adaptive antitumor immunity, especially CD8+ T cell immunity. FDX1 serves as a central regulator of CD8+ T cell functionality through DMBT1 downregulation during cuproptosis in colorectal cancer.
Jieqiong Wu +22 more
wiley +1 more source
GENDER AND AGE DISTRIBUTION AND CHEMICAL COMPOSITION OF RENAL STONES
Gomal Journal of Medical Sciences, 2014 Background: Renal stones are commonest urological disease worldwide. The objective of this study was to analyze the chemical composition of renal stones in relation to gender and age in District Dera Ismail Khan and its adjacent areas, Pakistan ...
Ghazi Khan +3 more
doaj
Facile syntheses of l-beta-haloalanine derivatives from l-cysteine or l-cystine
, 2009 l-beta-Haloalanines are physiologically active unnatural amino acids and they are useful intermediates for the synthesis of natural and unnatural amino acids, S-linked glycopeptides, and lanthionines.
Liu, Y +6 more
core
Contact Dermatitis, EarlyView.Gold release from gold‐plated earrings was investigated using a cysteine‐modified artificial sweat solution designed to reflect biochemically relevant conditions. This model enabled detection of low‐level gold release. Nickel release was quantified in parallel and was detected in all samples, frequently exceeding established regulatory limits. ABSTRACT
Mikkel Bak Jensen +6 more
wiley +1 more source
Cell Proliferation, EarlyView.Supplementing the liver preservation solution with agrimoniin protects donation after cardiac death (DCD) grafts by activating the Nrf‐2 pathway. This reduces ferroptosis, oxidative stress, and inflammation during cold storage, significantly improving graft viability.
Enqiang Chang +5 more
wiley +1 more source
Ocular cystinosis: Rarity redefined
Indian Journal of Ophthalmology, 2019 Mayuresh P Naik +2 more
doaj +1 more source